https://repositorio.fleni.org.ar/xmlui/handle/123456789/82 2026-04-05T18:42:27Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1411 Occipital structure is linked to vagal tone in borderline personality but not in major depressive disorder Camacho Téllez, Vicente; Castro, Mariana Nair; De Pino, Gabriela; Duarte-Abritta, Bárbara; Wainsztein, Agustina Edith; Lahitou Herlyn, Delfina; Goldberg, Ximena; Costanzo, Elsa; Cardoner, Narcís; Menchón, José M.; Soriano-Mas, Carles; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana Major depressive (MDD) and borderline personality disorders (BPD) are highly prevalent and frequently comorbid psychiatric conditions, both characterized by emotion dysregulation yet likely arising from distinct etiologies. Nonetheless, the specific features of autonomic central-peripheral relationships in these disorders remain poorly understood. We investigated the association between brain structure and vagal activity, and explored the resting-state functional connectivity of brain regions found to be associated with vagal tone, in 19 MDD, 18 BPD and 20 healthy controls (HC). We found that the cortical thinning in the right lateral occipital region was associated with increased parasympathetic tone in BPD, a relationship not observed in MDD. Moreover, in BPD, this region was functionally connected to the anterior insula and prefrontal areas, linked to the central autonomic system and emotion regulation processes. Accordingly, this region was also linked to emotion dysregulation in BPD. Our findings highlight distinct central-peripheral autonomic integration in these disorders and emphasize the occipital region's structural and functional involvement in emotional and autonomic regulation in BPD. Further research is needed to clarify how occipital structure and function, well as vagal activity, may contribute as potential biomarkers for BPD. 2025-08-09T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1371 Detección precoz de desregulación emocional en población infanto-juvenil sana Ladrón de Guevara, María Soledad La regulación emocional implica procesos intrínsecos y extrínsecos mediante los cuales los individuos monitorean, evalúan y modifican sus respuestas emocionales para alcanzar sus metas. Este estudio busca detectar signos de desregulación emocional en niños y adolescentes (7 a 17 años) a partir de una muestra de 45 sujetos. Se evaluó la flexibilidad cognitiva, la impulsividad, la presencia de experiencias adversas en la infancia y síntomas de depresión y ansiedad utilizando el Test de Cartas de Wisconsin (WSCT), la Escala de impulsividad de Barratt para niños (BIS11-c), el SCARED y el Inventario de Depresión para niños (CDI). Los resultados demostraron asociaciones significativas entre el trauma auto informado y síntomas de ansiedad y depresión. Un 51% de niños presentaron ansiedad, un 15% impulsividad y un 8% depresión. La flexibilidad cognitiva no mostro asociaciones significativas, mientras que la impulsividad se vinculó estrechamente con dificultades en la regulación emocional. 2024-01-01T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1072 Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: Insights from task-based and resting-state fMRI Fajardo Valdez, Alfonso; Camacho Téllez, Vicente; Rodríguez Cruces, Raúl; García Gomar, María Luisa; Pasaye, Erick Humberto; Concha, Luis Temporal lobe epilepsy (TLE) is a common form of medically intractable epilepsy. Although seizures originate in mesial temporal structures, there are widespread abnormalities of gray and white matter beyond the temporal lobes that negatively impact functional networks and cognition. Previous studies have focused either on the global impact on functional networks, or on the functional correlates of specific cognitive abilities. Here, we use a two-pronged approach to evaluate the link between whole-brain functional connectivity (FC) anomalies to overall cognitive performance, and how such abnormal connectivity alters the fronto-parietal brain regions involved in working memory (WMem), a cognitive disability often reported by TLE patients. We evaluated 31 TLE patients and 35 healthy subjects through extensive cognitive testing, resting-state functional magnetic resonance imaging (RS-fMRI), and task-based fMRI using Sternberg's task to evaluate WMem. As a group, TLE patients displayed cognitive abnormalities across different domains, although considerable within-group variability was identified. TLE patients showed disruptions of functional networks between and within the default mode network (DMN) and task-positive networks (TPN) resulting in associations with cognitive performance. Furthermore, during the WMem task, TLE patients showed abnormal activity of fronto-parietal regions that were associated with other forms of memory, and alterations of seed-based connectivity analyses. Our results show that different degrees of abnormal functional brain activity and connectivity are related to the severity of disabilities across cognitive spheres. Differential co-activation patterns between patients and healthy subjects suggest potential compensatory mechanisms to preserve adequate cognitive performance.; Servicio de Psiquiatría 2024-03-13T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1021 Psychopharmacology of smoking cessation medications: focus on patients with mental health disorders Castaldelli-Maia, João Mauricio; Camargos de Oliveira, Victoria; Irber, Flávia Mariana; Blaas, Israel Kanaan; Angerville, Bernard; Sousa Martins da Silva, Anderson; Koch Gimenes, Gislaine; Waisman Campos, Marcela; Torales, Julio César; Ventriglio, Antonio; Guillois, Carine; El Ouazzani, Houria; Gazaix, Léna; Favré, Pascal; Dervaux, Alain; Apter, Gisèle The adverse effects of smoking cessation in individuals with mental health disorders have been a point of concern, and progress in the development of treatment has been slow. The primary first-line treatments for smoking cessation are Nicotine Replacement Therapy, Bupropion, Varenicline, and behavioural support. Nortriptyline and Clonidine are second-line treatments used when the first-line treatments are not effective or are contraindicated. Smoking cessation medications have been shown to be effective in reducing nicotine cravings and withdrawal symptoms and promoting smoking cessation among patients living with mental disorders. However, these medications may have implications for patients' mental health and need to be monitored closely. The efficacy and side effects of these medications may vary depending on the patient's psychiatric condition, medication regimen, substance use, or medical comorbidities. The purpose of this review is to synthesise the pharmacokinetics, pharmacodynamics, therapeutic effects, adverse effects, and pharmacological interactions of first- and second-line smoking cessation drugs, with an emphasis on patients suffering from mental illnesses. Careful consideration of the risks and benefits of using smoking cessation medications is necessary, and treatment plans must be tailored to individual patients' needs. Monitoring symptoms and medication regimens is essential to ensure optimal treatment outcomes. 2023-09-05T00:00:00Z