https://repositorio.fleni.org.ar/xmlui/handle/123456789/1 Mon, 22 Jun 2026 17:47:51 GMT 2026-06-22T17:47:51Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1504 Detection of hearing loss by formal audiological testing after acute infectious meningitis : a global systematic review and meta-analysis Alviz, Luisa F.; Kim, Carla Y.; Benevides Tadinac, Ana Claudia; Roberts, Jackson A.; Monette, Lauren E.; Harrer, Caroline E.; Varela, Francisco José; Hwang, Soonmyung A.; Gebresilassie, Blen M.; Balcarce, Pilar; Prasad, Manya; Usseglio, John; Kothari, Kavita U.; Venuti, Francesco; Schiess, Nicoline; Gadama, Yohane; Binello, Nicolò; Chadha, Shelly; Dua, Tarun; Thakur, Kiran T. Background Acute community-acquired bacterial meningitis remains a significant global health concern with significant mortality and morbidity, including neurological sequelae such as sensorineural hearing loss (SNHL). Early detection of meningitis-associated SNHL mitigates permanent deafness and poor outcomes, including cognitive decline, social isolation, and mental health disorders. This systematic review evaluates the optimal time point(s) to perform formal audiological diagnostic testing and follow-up in adult and pediatric meningitis patients to effectively detect hearing loss (HL) outcomes. Methods A literature search was conducted across Medline, Embase, and Cochrane databases. Studies reporting the time frames for HL detection secondary to acute meningitis using formal audiological tests were included. Data were analyzed descriptively for continuous and categorical variables. A meta-analysis calculated the pooled prevalence of outcomes, with subgroup analyses stratified by the time frame of audiological diagnostic assessment. Results A total of 41 studies were included, with n=8105 meningitis patients comprising n=1397 (17.2%) adults and 6708 (82.8%) children. In adults, most audiological testing occurred post-discharge (n=530 vs. n=145), yet the proportion of hearing loss diagnoses was higher before discharge than after (45.5% vs. 42.5%). Similarly, more audiological assessments were administered post-discharge compared to pre-discharge (n=3340 vs. n=1975) in children, but HL diagnoses were more frequent before discharge (33.9% vs. 25.3%). The pooled prevalence of HL diagnoses during hospitalization or at discharge was 30.4% (95% CI 22.9–38%), compared to 22.9% (95% CI 12.6–33.1%) within 1 month post-discharge, 20.3% (95% CI 8.8–31.9%) between 30 and 60 days post-discharge, 22.7% (95% CI 12.1–33.4%) between 60 and 180 days post-discharge, and 10.8% (95% CI 5.9–15.7%) more than 180 days after discharge. Conclusions The considerable variability in the time frame of audiological test administration following an acute meningitis episode highlights the need for standardized auditory evaluations after meningitis diagnosis. Our findings emphasize that as hearing loss may occur and recover at different stages after an infectious meningitis episode, coordinated hearing assessments at discharge and during follow-up are important to ensure adequate detection and care. Sat, 28 Feb 2026 00:00:00 GMT https://repositorio.fleni.org.ar/xmlui/handle/123456789/1504 2026-02-28T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1503 Medication adherence in vascular prevention : findings from the SIFHON-ADH survey in Argentina Alet, Matías Javier; Ameriso, Sebastián Francisco; Rodriguez Pérez, María Soledad Resumen no disponible. Sat, 28 Feb 2026 00:00:00 GMT https://repositorio.fleni.org.ar/xmlui/handle/123456789/1503 2026-02-28T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1502 Mortalidad general y por diferentes causas en el partido de General Villegas, Buenos Aires, Argentina (2015–2020) : un análisis poblacional en el marco del estudio epidemiológico sobre el accidente cerebrovascular (EstEPA) Alet, Matías Javier; Melcon, Mario O.; Ameriso, Sebastián Francisco Introducción: Existen pocos estudios poblacionales recientes sobre mortalidad en Argentina, fuera del contexto de la pandemia por COVID-19. Nuestro objetivo fue describir la mortalidad general y por causas en el partido de General Villegas (Buenos Aires) entre 2015 y 2020, y compararla con tasas provinciales y nacionales. Materiales y métodos: Estudio de cohorte observacional poblacional que incluyó todas las defunciones en personas mayores de 18 años ocurridas entre junio de 2015 y mayo de 2020 en el partido de General Villegas (población total 35 251 habitantes). La información fue obtenida de certificados de defunción, historias clínicas, entrevistas y autopsias verbales. Las causas se codificaron según la Clasificación Estadística Internacional de Enfermedades y Problemas Relacionados con la Salud: CIE-10. Se calcularon tasas brutas y ajustadas por edad y sexo utilizando las poblaciones estándar de Argentina, OMS y Segi modificada para América Latina. Resultados: Se registraron 1031 muertes (56.5% hombres), con una tasa bruta de mortalidad de 9.7‰, superior a la provincial (8.2‰) y nacional (7.9‰). La tasa fue mayor en hombres (11.0‰) que en mujeres (8.4‰). Las tasas ajustadas fueron 5.2‰ (Argentina), 6.8‰ (Segi modificada) y 5.8‰ (OMS). Las enfermedades cardiovasculares (170/100 000; 25.4%) y los tumores (140/100 000; 21.5%) fueron las principales causas de mortalidad. En jóvenes de 18–39 años predominaron las causas externas (36%). Discusión: General Villegas presenta un perfil de mortalidad comparable al promedio nacional. Los datos obtenidos en este entorno estable y representativo pueden contribuir al diseño de estrategias regionales de salud pública orientadas a enfermedades crónicas y causas externas prevenibles. Thu, 01 Jan 2026 00:00:00 GMT https://repositorio.fleni.org.ar/xmlui/handle/123456789/1502 2026-01-01T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1500 Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention Sharma, Mukul; Dong, Qiang; Hirano, Teruyuki; Kasner, Scott E.; Saver, Jeffrey; Masjuan, Jaime; Demchuk, Andrew M.; Cordonnier, Charlotte; Bereczki, Daniel; Tsivgoulis, Georgios; Veltkamp, Roland; Staikov, Ivan; Bae, Hee-Joon; Campbell, Bruce C. V.; Zini, Andrea; Lee, I-Hui; Ameriso, Sebastián Francisco; Kovar, Martin; Mikulik, Robert; Lemmens, Robin Introduction: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. Patients and methods: Oral faCtor Eleven A iNhibitor asundexian as novel antithrombotiC (OCEANIC-STROKE) is a placebo-controlled, double-blind, event-driven randomised trial including participants with stroke (NIHSS ≤ 15) or high-risk TIA (ABCD2 6 or 7) within 72 h of onset. Participants had at least one of the following: atherosclerosis of extra- or intracranial vessels, a medical history of atherosclerosis or an imaged acute non-lacunar infarct. We excluded sources of stroke requiring anticoagulation and active non-trivial bleeding other than hemorrhagic infarction (HI 1 or 2). Participants received asundexian 50 mg daily or placebo stratified by planned concurrent antiplatelet therapy (single vs dual). The primary endpoint is time to ischemic stroke. We present baseline characteristics as of 5 June 2025. Results: Between January 2023 and February 2025, we randomised 12,327 participants. Participants were 67% male with a mean (SD) age of 68 (11) years. Ischemic stroke was the index event for 95% of whom 27.4% had thrombolysis and/or mechanical thrombectomy. By TOAST classification, 43% of index strokes were LAA, 22% small vessel disease, 30% undetermined and 2% cardioembolic. Dual antiplatelets were planned in 63% as standard initial treatment. Trial completion is anticipated in October 2025. Conclusion: OCEANIC-STROKE will be the first completed trial of FXIa inhibition for prevention of stroke after non-cardioembolic stroke or TIA. Thu, 01 Jan 2026 00:00:00 GMT https://repositorio.fleni.org.ar/xmlui/handle/123456789/1500 2026-01-01T00:00:00Z