• Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis 

  Mosquera Heredia, Maria I.; Vidal, Oscar M.; Morales, Luis C.; Silvera Redondo, Carlos; Barceló, Ernesto; Allegri, Ricardo Francisco; Arcos Burgos, Mauricio; Vélez, Jorge I.; Garavito Galofre, Pilar (MDPI, 2024-07-11)

  Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied ...
• Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation 

  Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco (Elsevier, 2024-09)

  We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem ...
• Perspectives on brain health and dementia prevention in Latin America: challenges and opportunities 

  Fox, Sarah; León, Tomás; Mariano, Luciano; Arshad, Faheem; Magrath Guimet, Nahuel; Hope, Grainne; Tituaña, Kuripacha; Zapata Restrepo, Lina María (Frontiers Media SA, 2023-10-16)

  While age-specific dementia prevalence is falling in many countries, several recent reviews estimate prevalence in Latin America to be higher than anywhere else in the world. This may be, in part, due to the high incidence ...
• Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina 

  Calandri, Ismael Luis; Livingston, Gill; Paradela, Regina; Ossenkoppele, Rik; Crivelli, Lucía; Allegri, Ricardo Francisco; Suemoto, Claudia K. (Karger, 2024-01-31)

  Introduction: Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such factors in middle- and low-income countries. We aimed to estimate the population-attributable ...
• Clinical Manifestations 

  Clarens, María Florencia; Chrem Méndez, Patricio Alexis; Tapajoz, Fernanda; Martinez, Carlos; Helou, María Belén; Surace, Ezequiel Ignacio; Crivelli, Lucía; Romero, Daniela; Vigo, Gabriela; Allegri, Ricardo Francisco (Wiley, 2023-12-25)

  Background: In recent years, there has been an increase in the number of case reports of families with autosomal dominant Alzheimer's disease (ADAD) in Latin America (LA). Nevertheless, little is known about the clinical ...
• Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial 

  Wagemann, Olivia; Liu, Haiyan; Wang, Guoqiao; Shi, Xinyu; Bittner, Tobias; Scelsi, Marzia A.; Farlow, Martin R.; Clifford, David B.; Supnet Bell, Charlene; Santacruz, Anna M.; Aschenbrenner, Andrew J.; Hassenstab, Jason J.; Benzinger, Tammie L.S.; Gordon, Brian A.; Coalier, Kelley A.; Cruchaga, Carlos; Ibanez, Laura; Perrin, Richard J.; Xiong, Chengjie; Li, Yan; Morris, John C.; Lah, James J.; Berman, Sarah B.; Roberson, Erik D.; van Dyck, Christopher H.; Galasko, Douglas; Gauthier, Serge; Hsiung, Ging-Yuek R.; Brooks, William S.; Pariente, Jérémie; Mummery, Catherine J.; Day, Gregory S.; Ringman, John M.; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network–Trials Unit (American Medical Association, 2024-06-01)

  Importance: Effects of antiamyloid agents, targeting either fibrillar or soluble monomeric amyloid peptides, on downstream biomarkers in cerebrospinal fluid (CSF) and plasma are largely unknown in dominantly inherited ...
• Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City 

  Sosa, Ana Luisa; Brucki, Sonia M.; Crivelli, Lucía; Lopera, Francisco Javier; Acosta, Daisy M.; Acosta Uribe, Juliana; Aguilar, Diego; Aguilar Navarro, Sara G.; Allegri, Ricardo Francisco; Bertolucci, Paulo H.; Calandri, Ismael Luis; Carrillo, María C.; Chrem Méndez, Patricio Alexis; Cornejo Olivas, Mario; Custodio, Nilton; Damián, Andrés; Cruz de Souza, Leonardo; Duran Aniotz, Claudia; García, Adolfo M.; Sevlever, Gustavo Emilio (John Wiley & Sons, 2024-05-27)

  Introduction: While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care. Methods: In 2023, ...
• Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset 

  Galvin, James E.; Cummings, Jeffrey L.; Levitchi Benea, Mihaela; de Moor, Carl; Allegri, Ricardo Francisco; Atri, Alireza; Chertkow, Howard; Paquet, Claire; Porter, Verna R.; Ritchie, Craig W.; Sikkes, Sikkes A.M.; Smith, Michael R.; Grassi, Christina Marsica; Rubino, Ivana (John Wiley & Sons, Ltd., 2024-05-06)

  Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes ...
• The impact of reward and punishment sensitivity on memory and executive performance in individuals with amnestic mild cognitive impairment 

  Corvalán, Nicolás; Crivelli, Lucía; Allegri, Ricardo Francisco; Pedreira, Maria E.; Fernández, Rodrigo S. (Elsevier/North-Holland Biomedical Pres, 2024-06-10)

  Amnestic mild cognitive impairment (aMCI) is defined by memory impairment but executive function (EF) deficits could be also a common feature. This study examined the underlying neurocognitive processes associated with ...
• Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease. 

  Iaccarino, Leonardo; Llibre Guerra, Jorge J.; McDade, Eric; Edwards, Lauren; Gordon, Brian A.; Benzinger, Tammie L.S.; Hassenstab, Jason; Kramer, Joel H.; Li, Yan; Miller, Bruce L.; Miller, Zachary; Morris, John C.; Mundada, Nidhi; Perrin, Richard J.; Rosen, Howard J.; Soleimani Meigooni, David; Strom, Amelia; Tsoy, Elena; Wang, Guoqiao; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Vázquez, Silvia (Oxford University Press, 2024-05-03)

  Approximately 5% of Alzheimer's disease patients develop symptoms before age 65 (early-onset Alzheimer's disease), with either sporadic (sporadic early-onset Alzheimer's disease) or dominantly inherited (dominantly inherited ...
• Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance 

  Howard, Leanne; Abdelnour, Carla; Abner, Erin L.; Allegri, Ricardo Francisco; Dodge, Hiroko H.; Gauthier, Serge; Hoyos, Camilla M.; Jicha, Gregory A.; Kehoe, Patrick G.; Mummery, Catherine J.; Ogunniyi, Adesola; Scarmeas, Nikolaos; Chen, Xiaoying; Titiner, Jodie R.; Weber, Christopher R.; Clinical Trial Methodology Working review group members; Peters, Ruth (John Wiley & Sons, 2024-06-02)

  Introduction: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated ...
• Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study 

  Wisch, Julie K.; McKay, Nicole S.; Boerwinkle, Anna H.; Kennedy, James; Flores, Shaney; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; O'Bryant, Sid E.; Price, Julie C.; Laymon, Charles M.; Krinsky-McHale, Sharon J.; Lai, Florence; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio (Lancet Pub. Group, 2024-05)

  Background: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and ...
• α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden 

  Levin, Johannes; Baiardi, Simone; Quadalti, Corinne; Rossi, Marcello; Mammana, Angela; Vöglein, Jonathan; Bernhardt, Alexander; Perrin, Richard J.; Jucker, Mathias; Preische, Oliver; Hofmann, Anna; Höglinger, Günter U.; Cairns, Nigel; Franklin, Erin E.; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2024-04-26)

  Introduction: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. Methods: ...
• Cognitive Rehabilitation Using Teleneuropsychology. A Cohort Study in South America 

  Martínez Canyazo, Carlos; Fernández, Rodrigo Sebastián; Helou, María Belén; Arruabarrena, Micaela María; Corvalán, Nicolás; Carello, María Agostina; Harris, Paula; Feldman, Mónica; Calandri, Ismael Luis; Martin, María Eugenia; Allegri, Ricardo Francisco; Crivelli, Lucía (Cambridge University Press, 2023-12-21)

  Objective: The COVID-19 pandemic has affected the continuity of cognitive rehabilitation (CR) worldwide. However, the use of teleneuropsychology (TNP) to provide CR has contributed significantly to the continuity of ...
• Criminal behaviors: A theory of mind problem? 

  Mariani, Francesca; Calandri, Ismael Luis; Dansilio, Sergio (Taylor & Francis Group, 2024-02-11)

  Theory of mind (ToM) has been addressed in relation to functional alterations of certain brain regions and their connections. The objective is to evaluate ToM in imprisoned criminal offenders and to analyze their relationship ...
• Performance on the Latin American version of the Face-Name Associative Memory Exam (LAS-FNAME) distinguishes individuals with Mild Cognitive Impairment from age-matched controls in a sample from Argentina. 

  Keller, Greta; Corvalán, Nicolás; Carello, María Agostina; Arruabarrena, Micaela María; Martínez Canyazo, Carlos; De Los Santos, Loana; Spehrs, Julieta; Vila-Castelar, Clara; Allegri, Ricardo Francisco; Quiroz, Yakeel T.; Crivelli, Lucía (Taylor & Francis, 2024-03-06)

  Introduction: The Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) has shown promise in identifying cognitive changes in those at risk for Alzheimer's disease (AD). However, its applicability ...
• Prevalence and Trajectories of Post-COVID-19 Neurological Manifestations: A Systematic Review and Meta-Analysis 

  Giussani, Giorgia; Westenberg, Érica; García-Azorín, David; Bianchi, Elisa; Yusof Khan, Abdul Hanif Khan; Allegri, Ricardo Francisco; Atalar, Arife Çimen; Baykan, Betul; Crivelli, Lucía; Fornari, Arianna; Frontera, Jennifer; Guekht, Alla; Helbok, Raimund; Kee Hoo, Fan; Kivipelto, Miia; Leonardi, Matilde; López Rocha, Ana Sabsil; Mangialasche, Francesca; Marcassoli, Alessia; Global COVID-19 Neuro Research Coalition (Karger, 2024-01-25)

  Introduction: The aim of this systematic review and meta-analysis was to evaluate the prevalence of thirteen neurological manifestations in people affected by COVID-19 during the acute phase and at 3, 6, 9 and 12-month ...
• Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease 

  Llibre Guerra, Jorge J.; Iaccarino, Leonardo; Coble, Dean; Edwards, Lauren; Li, Yan; McDade, Eric; Strom, Amelia; Gordon, Brian A.; Mundada, Nidhi; Schindler, Suzanne E.; Tsoy, Elena; Ma, Yinjiao; Lu, Ruijin; Fagan, Anne M.; Benzinger, Tammie L.S.; Soleimani Meigooni, David; Aschenbrenner, Andrew J.; Allegri, Ricardo Francisco; Patricio Alexis, Chrem Méndez; Surace, Ezequiel Ignacio (Oxford University Press, 2023-10-18)

  Approximately 5% of Alzheimer's disease cases have an early age at onset (<65 years), with 5-10% of these cases attributed to dominantly inherited mutations and the remainder considered as sporadic. The extent to which ...
• Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition 

  Frontera, Jennifer; Guekht, Alla; Allegri, Ricardo Francisco; Ashraf, Mariam; Baykan, Betül; Crivelli, Lucía; Easton, Ava; Garcia-Azorin, David; Helbok, Raimund; Joshi, Jatin; Koehn, Julia; Koralnik, Igor; Netravathi, M.; Benedict, Michael; Nilo, Annacarmen; Özge, Aynur; Padda, Karanbir; Pellitteri, Gaia; Prasad, Kameshwar; Romozzi, Marina (Elsevier, 2023-11-15)

  Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline ...
• Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage 

  Joseph-Mathurin, Nelly; Feldman, Rebecca L.; Lu, Ruijin; Shirzadi, Zahra; Toomer, Carmen; Saint Clair, Junie R.; Ma, Yinjiao; McKay, Nicole S.; Strain, Jeremy F.; Kilgore, Collin; Friedrichsen, Karl A.; Chen, Charles D.; Gordon, Brian A.; Chen, Gengsheng; Hornbeck, Russ C.; Massoumzadeh, Parinaz; McCullough, Austin; Wang, Qing; Li, Yan; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2024-02-21)

  Introduction: Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's disease (DIAD) presenilin-1 (PSEN1) mutation carriers. We investigated ...

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