https://repositorio.fleni.org.ar/xmlui/handle/123456789/31 2026-08-12T05:42:52Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1557 Neuro-Otologic Manifestations of Multiple Sclerosis Laffue, Alfredo Hernan Multiple sclerosis is a common demyelinating disease of the central nervous system (CNS) that often presents with vestibular symptoms, including vertigo, nystagmus, and oculomotor disturbances. These manifestations occur in 4–67% of patients and can mimic peripheral vestibular disorders, making diagnosis challenging. Lesions affecting central vestibular and cerebellar pathways account for three main clinical presentations: acute vestibular syndrome, positional vertigo, and chronic imbalance. Distinguishing central from peripheral causes is crucial for accurate diagnosis. Videonystagmography and the video head impulse test enhance diagnostic precision. This chapter reviews the neurotological features of multiple sclerosis (MS) and underscores the role of vestibular testing in clinical evaluation and patient management. 2026-02-17T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/272 Bilateral posterior semicircular canal dysfunction: a new finding with video head impulse test Lerchundi, Florencia; Laffue, Alfredo Hernan; Olivier, Marina; Gualtieri, Francisco José Development of the video head impulse test (vHIT) assessing all three semicircular canals in both labyrinths has uncovered the existence of new vestibular failure patterns and made bilateral posterior canal dysfunction detection possible. We conducted a retrospective analysis of 41 patients with bilateral posterior semicircular canal failure and compared results to 37 controls, with normal posterior semicircular canal function. Mean calculated gain showed significant difference between patients and controls in right [0.54 (SD 0.016)] and left [0.57 (SD 0.014)] posterior semicircular canals. There was a peak in prevalence between 71 and 80 years. Presentation was chronic in 78% of patients, and gait instability was the most common complaint. Sixty eight percent of cases were classified as idiopathic. Significant difference between groups was seen regarding the presence of Meniere's disease, presbycusis, and positional down-beat nystagmus (posDBN). This new vHIT pattern is most often seen in elderly patients, mainly of idiopathic etiology and presents together with sensorineural hearing loss and posDBN. Our findings suggest idiopathic cases may well contribute to the so-called "presbyastasis". 2020-07-01T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/201 Video Head Impulse Test Contributes to Susac Syndrome Diagnosis Marrodán, Mariano; Laffue, Alfredo Hernan; Fiol, Marcela Paula; Correale, Jorge; Gualtieri, Francisco José Resumen no disponible 2019-05-07T00:00:00Z