https://repositorio.fleni.org.ar/xmlui/handle/123456789/76 2026-04-05T17:01:48Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1486 Coma due to tension pneumocephalus in the posterior fossae Maskin, Luis Patricio; Cabañuz, Florencia; Rodriguez Lucci, Federico No abstract available. 2025-12-26T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1475 Valoración de la calidad del sueño en pacientes con artritis reumatoide, espondiloartritis y lupus eritematoso sistémico: estudio del noreste argentino Ringer, Ariana; Antoniol, María Noelia; Aste, Nora; Benavente, Emilio Pablo Ignacio; Gallino, Josefina; Schmid, María Marcela; Mauri, Marianela Eliana; Seewald, Adriana; Paris, Úrsula Vanesa; Bravo, Maximiliano; Catay, Erika Roxana; Sattler, María Emilia; Góngora, Vanina; Finucci Curi, Pablo; Velozo, Edson Javier Introducción: las patologías autoinmunes y sus tratamientos pueden relacionarse con la calidad del sueño. Objetivos: evaluar la calidad del sueño en pacientes con artritis reumatoide (AR), espondiloartritis (SpA) y lupus eritematoso sistémico (LES) a través del cuestionario de Pittsburgh de calidad del sueño (PSQI) en las provincias del noreste argentino. Materiales y métodos: estudio multicéntrico (filial ARNEA), transversal, analítico y descriptivo. Se incluyeron pacientes con AR, SpA y LES. Se evaluó la calidad del sueño mediante PSQI. Se registraron índices de actividad, cronicidad y tratamientos para cada patología. Se realizó un análisis descriptivo y multivariado. Resultados: se evaluaron 163 pacientes. Predominó la AR, seguida del LES. Según el PSQI, la calidad del sueño fue mala en un 77,3% y el 65% refirió múltiples problemas del sueño. En los pacientes con AR se observó una asociación estadísticamente significativa entre mayor DAS28 y mala calidad del sueño (OR 3.06; IC 95% 1,37-6,84; p=0,006). El uso de corticoides se asoció con un mayor PSQI. No hubo diferencias en la calidad del sueño ni el PSQI según patologías. Conclusiones: la mala calidad del sueño fue altamente prevalente en pacientes con patologías autoinmunes, especialmente en aquellos con mayor actividad inflamatoria. Es importante incorporar la evaluación del sueño en la práctica clínica habitual. 2025-05-29T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1453 Whole-Body Skeletal Muscle MRI Patterns in Female Dystrophinopathy Carriers Alejandra, Vigliano; Luce, Leonela; Pastor Rueda, José Manuel; Chaves, Hernan; Mesa, Lilia; Carcione, Micaela; Mazzanti, Chiara; Llames Massini, Carmen; Radic, Claudia Pamela; Cejas, Claudia Patricia; Giliberto, Florencia Background and objectives: Dystrophinopathies are X-linked recessive diseases caused by pathogenic variants in the Duchenne muscular dystrophy (DMD) gene. Some women carrying a single DMD pathogenic variant manifest variable levels of symptomatology. Those who manifest severe and early-onset symptoms are considered to be affected by dystrophinopathy rather than carriers. The aim of this study was to characterize and compare muscle structure between female DMD carriers who were asymptomatic at the time of the study and female control participants using whole-body MRI (WB-MRI) and correlate the findings with clinical and genetic data. Methods: We conducted a cross-sectional observational study comparing a group of female carriers of DMD pathogenic variants and a group of healthy noncarrier controls. The first group included obligate and genetically confirmed DMD female carriers, not classified as having dystrophinopathy. Women in the healthy group had no family history of DMD or other muscular dystrophies. All individuals underwent WB-MRI, which was evaluated using qualitative grading scales to assess muscle edema, trophism, and fatty infiltration. Neurologic examinations, serum creatine kinase measurement, DMD genetic screening, and X-chromosome inactivation studies were performed on the DMD carriers. Results: The study included 29 DMD female carriers and 30 healthy noncarrier controls. All DMD carriers showed signs of muscle involvement on MRI, revealing a larger proportion of skeletal muscle involvement in carriers than in controls (85% vs 27% of 48 examined muscles/group of muscles, p < 0.001). Edema, fatty infiltration, and atrophy were more common in DMD carriers (62.5% vs 8%; 81% vs 35%; and 81% vs 25%, respectively, all p < 0.001), particularly in muscles of the calves, thighs, and pelvic region. The most frequently affected muscles were gastrocnemius, gluteus maximus, and soleus. No correlations were found between the MRI results and the clinical and genetic data. Discussion: Our findings indicate that DMD female carriers who are asymptomatic at the time of our study may be at risk of developing muscle symptoms at a future time. Multidisciplinary surveillance of DMD female carriers will facilitate early detection and management of complications. 2025-09-30T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1451 Gender gap in medicine: a call to action for Latin America Negrotto, Laura; Corona Vázquez, Teresita; Ibañez, Carolina; Montenegro, Paola; Monterrey, Priscilla; Pupareli, Carmen; Ruiz-García, Erika; Saldarriaga Giraldo, Clara Inés; Samama, Marise; Soria Samaniego, Tannia; Sowley, Taysser; Ysrraelit, María Célica; Díaz, Ivonne Andrea Resumen no disponible 2025-08-29T00:00:00Z