https://repositorio.fleni.org.ar/xmlui/handle/123456789/1439 Wed, 12 Aug 2026 05:41:58 GMT 2026-08-12T05:41:58Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1552 Vasculitis del sistema nervioso central en pacientes inmunocompetentes con criptococosis meníngea Camporro, Julieta; Varela, Francisco; Yañez, Paulina; Bravo, Martín; Tomatis, Antonela; Mora, Andrea La criptococosis meníngea (CM) es una infección micótica grave que puede presentarse en individuos inmunocompetentes. Su diagnóstico presenta difi cultades debido a su baja frecuencia y presentación clínica variable. Las complicaciones neurológicas, como la vasculitis del sistema nervioso central (SNC) con infartos cerebrales, puede dificultar el manejo clínico. En este trabajo retrospectivo observacional, se pre sentan dos casos de CM en pacientes inmunocompeten tes que desarrollaron vasculitis del SNC. Se revisaron las historias clínicas y se describió el tratamiento instaura do y evolución clínica. Ambos pacientes fueron tratados con esteroides. El primero requirió un tratamiento prolongado con esteroides y antifúngicos debido a la recurrencia de síntomas y lesiones cerebrales. El segundo mostró me joría clínica con la administración inicial de esteroides y antifúngicos. Estos casos resaltan la importancia de considerar la CM en el diagnóstico diferencial de pacientes inmu nocompetentes, y el uso de corticoides en casos que presenten vasculitis de SNC. Fri, 05 Sep 2025 00:00:00 GMT https://repositorio.fleni.org.ar/xmlui/handle/123456789/1552 2025-09-05T00:00:00Z https://repositorio.fleni.org.ar/xmlui/handle/123456789/1438 WHO guidelines on meningitis diagnosis, treatment and care [Internet] World Health Organization In line with the Defeating meningitis by 2030: a global road map, the WHO guidelines on meningitis diagnosis, treatment and care provide evidence-based recommendations for the clinical management of children and adults with community-acquired meningitis, including acute and long-term care. Meningitis poses a significant public health threat, despite successful efforts to control the disease globally. The burden of morbidity and mortality from meningitis remains high, particularly in low- and middle-income countries and in settings experiencing large-scale, disruptive epidemics. Approximately one in five individuals affected by bacterial meningitis incurs long-term complications, which may result in disability and have a profound impact on quality of life. The guidelines are primarily intended for health-care professionals working in first- or second-level health-care facilities, including emergency, inpatient and outpatient services. They are also directed at policy-makers, health-care planners and programme managers, academic institutions, non-governmental and civil society organizations to inform capacity-building, teaching and research agendas. Web annex A provides the quantitative evidence reports, Web annex B summarizes the qualitative and economic evidence and Web annex C presents the Evidence-to-Decision frameworks. Wed, 01 Jan 2025 00:00:00 GMT https://repositorio.fleni.org.ar/xmlui/handle/123456789/1438 2025-01-01T00:00:00Z