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ListarINEU.artículos por tema "Enfermedad de Alzheimer"

ListarINEU.artículos por tema "Enfermedad de Alzheimer"

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  • A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects 
    Acosta-Uribe, Juliana; Aguillón, David; Cochran, J. Nicholas; Giraldo, Margarita; Madrigal, Lucía; Killingsworth, Bradley W.; Singhal, Rijul; Labib, Sarah; Alzate, Diana; Velilla, Lina M.; Moreno, Sonia; García, Gloria P.; Saldarriaga, Amanda; Piedrahita, Francisco; Hincapié, Liliana; López, Hugo E.; Perumal, Nithesh; Surace, Ezequiel Ignacio; Itzcovich, Tatiana; Allegri, Ricardo Francisco (BioMed Central, 2022-03-08)
    Background: The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed ...
  • Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium 
    Quiroz, Yakeel T.; Solis, Michele; Aranda, María P.; Arbaje, Alicia I.; Arroyo-Miranda, Mirna; Cabrera, Laura Y.; Carrasquillo, Minerva Maria; Corrada, Maria M.; Crivelli, Lucía; Diminich, Erica D.; Dorsman, Karen A.; Gonzales, Mitzi; González, Héctor M.; Gonzalez-Seda, Ana L.; Grinberg, Lea T.; Guerrero, Lourdes R.; Hill, Carl V.; Jiménez-Velázquez, Ivonne; Llibre Guerra, Jorge J.; Lopera, Francisco (John Wiley & Sons, 2022-09)
    The Alzheimer's Association hosted the second Latinos & Alzheimer's Symposium in May 2021. Due to the COVID-19 pandemic, the meeting was held online over 2 days, with virtual presentations, discussions, mentoring sessions, ...
  • Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome 
    Gorijala, Priyanka; Aslam, M. Muaaz; Dang, Lam-Ha T.; Xicota, L.; Fernández, María V.; Sung, Yun Ju; Fan, Kang-Hsien; Feingold, Eleanor; Surace, Ezequiel Ignacio; Chhatwal, Jasmeer P.; Hom, Christy L.; Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI); NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigators; Hartley, Sigan L.; Hassenstab, Jason; Perrin, Richard J.; Mapstone, Mark; Zaman, Shahid H.; Ances, Beau M.; Kamboh, M. Ilyas; Lee, Joseph H.; Cruchaga, Carlos (John Wiley & Sons, 2023-10-19)
    Introduction: This study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers. Methods: ...
  • Amyloid and anatomical correlates of executive functioning in middle-aged offspring of patients with late-onset Alzheimer's disease 
    Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Abulafia, Carolina; Gustafson, Deborah R.; Vázquez, Silvia; Sevlever, Gustavo Emilio; Castro, Mariana Nair; Fiorentini, Leticia; Villarreal, Mirta Fabiana; Guinjoan, Salvador Martín (Elsevier, 2021-10-30)
    A traditional hallmark of cognitive impairment associated with late-onset Alzheimer´s disease (LOAD) is episodic memory impairment. However, early alterations have been identified in brain regions associated with executive ...
  • Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology 
    Morris, John C.; Weiner, Michael W.; Xiong, Chengjie; Beckett, Laurel A.; Coble, Dean; Saito, Naomi; Aisen, Paul S.; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Cairns, Nigel; Carrillo, María C.; Chui, Helena C.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Fagan, Anne M.; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Goate, Alison M. (Oxford University Press, 2022-10-21)
    The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of 'sporadic' late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings ...
  • Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease 
    Johnson, Erik C. B.; Bian, Shijia; Haque, Rafi U.; Carter, E. Kathleen; Watson, Caroline M.; Gordon, Brian A.; Ping, Lingyan; Duong, Duc M.; Epstein, Michael P.; McDade, Eric; Barthélemy, Nicolas R.; Karch, Celeste M.; Xiong, Chengjie; Cruchaga, Carlos; Perrin, Richard J.; Wingo, Aliza P.; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2023-08-07)
    Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease 
    Allegri, Ricardo Francisco; Dincer, Aylin; Gordon, Brian A.; Hari-Raj, Amrita; Keefe, Sarah J.; Flores, Shaney; McKay, Nicole S.; Paulick, Angela M.; Shady Lewis, Kristine E.; Feldman, Rebecca L.; Hornbeck, Russ C.; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Farlow, Martin R.; La Fougère, Christian; Fox, Nick C.; Fulham, Michael J.; Jack Jr, Clifford R.; Joseph-Mathurin, Nelly; Karch, Celeste M.; Lee, Athene; Levin, Johannes; Masters, Colin L.; McDade, Eric; Oh, Hwamee; Perrin, Richard J.; Raji, Cyrus; Salloway, Stephen; Schofield, Peter R.; Su, Yi; Villemagne, Victor L.; Wang, Qing; Weiner, Michael W.; Xiong, Chengjie; Yakushev, Igor; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L.S.; Dominantly Inherited Alzheimer Network (Elsevier, 2020-11-05)
    Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
  • Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole S.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)
    Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • Design of a Non-Interventional Study to Assess Neurologists' Perspectives and Pharmacological Treatment Decisions in Early Alzheimer's Disease 
    Saposnik, Gustavo; Sánchez-Benavidez, Gonzalo; García-Arcelay, Elena; Franco-Macías, Emilio; Bensi, Catalina; Carmelingo, Sebastián; Allegri, Ricardo Francisco; Pérez-Martíne, David A.; Maurino, Jorge (Springer, 2023-03-23)
    Introduction: The current therapeutic landscape of Alzheimer's disease (AD) is evolving rapidly. Our treatment options include new anti-amyloid-β protein disease-modifying therapies (DMTs) that decrease cognitive decline ...
  • Diabetic patients treated with metformin during early stages of Alzheimer's disease show a better integral performance: data from ADNI study 
    Pomilio, Carlos; González Pérez, Nicolás; Calandri, Ismael Luis; Crivelli, Lucía; Allegri, Ricardo Francisco; ADNI Alzheimer’s Disease Neuroimaging Initiative; Sevlever, Gustavo Emilio; Saravia, Flavia (Springer International Publishing, 2022-06)
    We evaluated the effect of the antidiabetic drug metformin on patients enrolled in the ADNI study considering patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Employing data from this observational ...
  • Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer's disease in Colombia 
    Porto, Maria F.; Benitez Agudelo, Juan Camilo; Aguirre Acevedo, Daniel Camilo; Barceló Martínez, Ernesto; Allegri, Ricardo Francisco (Taylor & Francis, 2021-03-24)
    Background: Alzheimer's disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. ...
  • Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease 
    Del Cerro, Inés; Villarreal, Mirta Fabiana; Abulafia, Carolina; Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Castro, Mariana Nair; Bocaccio, Hernán; Ferrer, Isidre; Menchón, José Manuel; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Soriano-Mas, Carles; Guinjoan, Salvador Martín (Pergamon Press, 2020-04)
    Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
  • Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes 
    Llibre Guerra, Jorge J.; Li, Yan; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Llibre Rodríguez, Juan J.; Sosa, Ana Luisa; Aláez-Verson, Carmen; Longoria, Erika-Mariana; Tellez, Alberto; Carrillo Sánchez, Karol; Flores Lagunes, Luis Leonardo; Sánchez, Victor; Tadao Takada, Leonel; Nitrini, Ricardo; Ferreira Frota, Norberto Anizio; Benevides Lima, Joyce; Lopera, Francisco; Ramírez, Laura; Jiménez Velázquez, Ivonne (John Wiley & Sons, 2021-04)
    Introduction: A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country ...
  • Driving and Alzheimer’s disease: A neuropsychological screening battery for the elderly 
    Crivelli, Lucía; Russo, María Julieta; Farez, Mauricio Franco; Bonetto, Mariana; Prado, Cecilia; Calandri, Ismael Luis; Campos, Jorge; Cohen, Gabriela; Chrem Méndez, Patricio Alexis; Sabe, Liliana Raquel; Allegri, Ricardo Francisco (Associação Neurologia Cognitiva e do Comportamento, 2019-07-01)
    As life expectancy increases, there is a marked increase in the elderly population eager to continue driving. A large proportion of these elderly drive safely, however, patients with mild dementia are high-risk drivers. ...
  • First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study 
    O'Connor, Antoinette; Rice, Helen; Barnes, Josephine; Ryan, Natalie S.; Liu, Kathy Y.; Allegri, Ricardo Francisco; Berman, Sarah B.; Ringman, John M.; Cruchaga, Carlos; Farlow, Martin R.; Hassenstab, Jason; Lee, Jae-Hong; Perrin, Richard J.; Xiong, Chengjie; Gordon, Brian A.; Levey, Allan I.; Goate, Alison M.; Graff-Radford, Neill R.; Levin, Johannes; Dominantly Inherited Alzheimer Network (BMJ Publishing Group, 2022-12-15)
  • Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient 
    Isaja, Luciana; Rodríguez Varela, María Soledad; Marazita, Mariela Claudia; Mucci, Sofía; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Niikado, Matías; Ferriol-Laffouillere, Sofía Luján; Allegri, Ricardo Francisco; Martinetto, Horacio; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Romorini, Leonardo (Elsevier, 2021-04-05)
    Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male ...
  • LatAm FINGERS:Overcoming Barriers for a Dementia Prevention Trial Startup 
    Calandri, Ismael Luis; Crivelli, Lucía; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Mónica; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; LatAm FINGERS initiative (The Alzheimer's Association, 2022)
  • Latin America has been under-represented in dementia clinical trials, we must turn the corner 
    Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2022-06-11)
    The world’s population is aging, life expectancy is increasing in the past century as result of the improvements in healthcare and the people arrive to live longer and healthier. However, this has also resulted in increase ...

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