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Browsing by Author "Facal, Carolina Lucía"

Browsing by Author "Facal, Carolina Lucía"

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  • SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy 
    Muñiz, Javier Andrés; Facal, Carolina Lucía; Urrutia, Leandro; Clerici Delville, Ramiro; Damianich, Ana; Ferrario, Juan Esteban; Falasco, Germán; Avale, María Elena (Frontiers Media S.A., 2022-09-05)
    Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, ...
  • Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy 
    Damianich, Ana; Facal, Carolina Lucía; Muñiz, Javier Andrés; Mininni, Camilo; Soiza Reilly, Mariano; Ponce de León, Magdalena; Urrutia, Leandro; Falasco, Germán; Ferrario, Juan Esteban; Avale, María Elena (Oxford, 2021-06-01)
    Tauopathies are neurodegenerative diseases caused by the abnormal metabolism of the microtubule associated protein Tau, which is highly expressed in neurons and critically involved in microtubule dynamics. In the adult ...
  • Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice 
    Facal, Carolina Lucía; Fernández Bessone, Iván; Muñiz, Javier Andrés; Pereyra, A. Ezequiel; Pedroncini, Olivia; Páez Paz, Indiana; Clerici Delville, Ramiro; Arnaiz, Cayetana; Urrutia, Leandro; Falasco, Germán; Argañaraz, Carla Verónica; Saez, Trinidad; Marin Burgin, Antonia; Soiza Reilly, Mariano; Falzone, Tomás; Avale, María Elena (Cell Press, 2024-02-03)
    Abnormal tau accumulation is the hallmark of several neurodegenerative diseases, named tauopathies. Strategies aimed at reducing tau in the brain are promising therapeutic interventions, yet more precise therapies would ...

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