Repositorio Dspace

Listar por autor "Karch, Celeste M."

Listar por autor "Karch, Celeste M."

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  • AD-causing variants that affect PSEN1 transmembrane domains are associated with faster neurodegeneration and cognitive decline compared to those affecting cytoplasmic domains 
    Schultz, Stephanie A.; Allegri, Ricardo Francisco; Schultz, Aaron P.; Goate, Alison M.; Levey, Allan I.; Fagan, Anne M.; Hanseeuw, Bernard J.; Koeppe, Robert A.; Gordon, Brian A.; Cruchaga, Carlos; Karch, Celeste M.; Chen, Charles D.; Xiong, Chengjie; Jack Jr, Clifford R.; Fitzpatrick, Colleen D.; McDade, Eric; Chui, Helena C.; Mori, Hiroshi; Lee, Jae-Hong; Noble, James M. (Wiley, 2022-12)
    Background Rates of cognitive and biomarker change in Autosomal Dominant Alzheimer disease (ADAD) vary substantially across individuals. Prior cross-sectional work suggests that the location of the pathogenic variant ...
  • Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease 
    Millar, Peter R.; Gordon, Brian A.; Wisch, Julie K.; Schultz, Stephanie A.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Hassenstab, Jason J.; Ibanez, Laura; Karch, Celeste M.; Llibre Guerra, Jorge J.; Morris, John C.; Perrin, Richard J.; Supnet Bell, Charlene; Xiong, Chengjie; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Day, Gregory S.; Dominantly Inherited Alzheimer Network (BioMed Central, 2023-12-19)
    Background: "Brain-predicted age" estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease ...
  • Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease 
    Llibre Guerra, Jorge J.; Li, H; Schindler, Suzanne E.; Gordon, Brian A.; Fagan, Anne M.; Morris, John C.; Benzinger, Tammie L.S.; Hassenstab, Jason; Wang, Guoquiao; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Farlow, Martin R.; Holtzman, David M.; Jucker, Mathias; Levin, Johannes; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Karch, Celeste M.; Fox, Nick C.; Xiong, Chengjie; Bateman, Randall J.; McDade, Eric (American Medical Association, 2019-12-02)
    The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. ...
  • Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN) 
    Aschenbrenner, Andrew J.; James, Bryan D.; McDade, Eric; Wang, Guoquiao; Lim, Yen Ying; Benzinger, Tammie L.S.; Cruchaga, Carlos; Goate, Alison M.; Xiong, Chengjie; Perrin, Richard J.; Buckles, Virginia; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Fagan, Anne M.; Farlow, Martin R.; O’Connor, Antoinette; Ghetti, Bernardino; Graff-Radford, Neill R.; Goldman, Jill; Gräber, Susanne; Karch, Celeste M.; Lee, Jae-Hong; Levin, Johannes; Martins, Ralph N.; Masters, Colin L.; Mori, Hiroshi; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Morris, John C.; Bateman, Randall J.; Hassenstab, Jason; Dominantly Inherited Alzheimer Network; Dominantly Inherited Alzheimer Network (Wiley, 2020-06)
    Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is ...
  • Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease 
    Montal, Victor; Vilaplana, Eduard; Pegueroles, Jordi; Bejanin, Alexandre; Alcolea, Daniel; Carmona-Iragui, María; Clarimón, Jordi; Levin, Johannes; Cruchaga, Carlos; Graff-Radford, Neill R.; Noble, James M.; Lee, Jae-Hong; Allegri, Ricardo Francisco; Karch, Celeste M.; Laske, Christoph; Schofield, Peter R.; Salloway, Stephen; Ances, Beau M.; Benzinger, Tammie L.S.; McDade, Eric; Bateman, Randall J.; Blesa, Rafael; Sánchez-Valle, Raquel; Lleó, Alberto; Fortea, Juan; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2020-11-16)
    Methods: In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical ...
  • Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease 
    Johnson, Erik C. B.; Bian, Shijia; Haque, Rafi U.; Carter, E. Kathleen; Watson, Caroline M.; Gordon, Brian A.; Ping, Lingyan; Duong, Duc M.; Epstein, Michael P.; McDade, Eric; Barthélemy, Nicolas R.; Karch, Celeste M.; Xiong, Chengjie; Cruchaga, Carlos; Perrin, Richard J.; Wingo, Aliza P.; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2023-08-07)
    Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease 
    Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.S.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison M.; Buckles, Virginia; Fox, Nick C.; Rossor, Martin N.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Ringman, John M.; Höglinger, Günter; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes; Dominantly Inherited Alzheimer Network (Oxford, 2019-03-20)
    Owing to an early and marked deposition of amyloid-β in the basal ganglia, autosomal dominant Alzheimer’s disease could distinctly involve motor symptoms. Therefore, we aimed to assess the prevalence and characteristics ...
  • Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease 
    Allegri, Ricardo Francisco; Dincer, Aylin; Gordon, Brian A.; Hari-Raj, Amrita; Keefe, Sarah J.; Flores, Shaney; McKay, Nicole S.; Paulick, Angela M.; Shady Lewis, Kristine E.; Feldman, Rebecca L.; Hornbeck, Russ C.; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Farlow, Martin R.; La Fougère, Christian; Fox, Nick C.; Fulham, Michael J.; Jack Jr, Clifford R.; Joseph-Mathurin, Nelly; Karch, Celeste M.; Lee, Athene; Levin, Johannes; Masters, Colin L.; McDade, Eric; Oh, Hwamee; Perrin, Richard J.; Raji, Cyrus; Salloway, Stephen; Schofield, Peter R.; Su, Yi; Villemagne, Victor L.; Wang, Qing; Weiner, Michael W.; Xiong, Chengjie; Yakushev, Igor; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L.S.; Dominantly Inherited Alzheimer Network (Elsevier, 2020-11-05)
    Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
  • Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease 
    Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack Jr, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network and the Alzheimer’s Disease Neuroimaging Initiative (American Medical Association, 2023-12-01)
    Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains ...
  • Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid 
    Drieu, Antoine; Du, Siling; Storck, Steffen E.; Rustenhoven, Justin; Papadopoulos, Zachary; Dykstra, Taitea; Zhong, Fenghe; Kim, Kyungdeok; Blackburn, Susan; Mamuladze, Tornike; Harari, Oscar; Karch, Celeste M.; Bateman, Randall J.; Perrin, Richard J.; Farlow, Martin R.; Chhatwal, Jasmeer; Dominantly Inherited Alzheimer Network; Hu, Song; Randolph, Gwendalyn J.; Allegri, Ricardo Francisco (Nature Publishing Group, 2022-11)
    Macrophages are important players in the maintenance of tissue homeostasis1. Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma2, and their role in CNS physiology has not ...
  • Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease 
    Ewers, Michael; Luan, Ying; Frontzkowski, Lukas; Neitzel, Julia; Rubinski, Anna; Dichgans, Martin; Hassenstab, Jason; Gordon, Brian A.; Chhatwal, Jasmeer P.; Levin, Johannes; Schofield, Peter R.; Benzinger, Tammie L.S.; Morris, John C.; Goate, Alison M.; Karch, Celeste M.; Fagan, Anne M.; McDade, Eric; Allegri, Ricardo Francisco; Berman, Sarah B.; Chui, Helena C. (Oxford, 2021-03-16)
    Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's disease, but the functional brain mechanisms that support cognitive resilience remain elusive. Given previous findings in normal ...
  • Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease 
    Vermunt, Lisa; Dicks, Ellen; Wang, Guoqiao; Dincer, Aylin; Flores, Shaney; Keefe, Sarah J.; Berman, Sarah B.; Cash, David M.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Fox, Nick C.; Ghetti, Bernardino; Graff-Radford, Neill R.; Hassenstab, Jason; Karch, Celeste M.; Laske, Christoph; Levin, Johannes; Masters, Colin L.; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco (Oxford University Press, 2020-06-15)
    Structural grey matter covariance networks provide an individual quantification of morphological patterns in the brain. The network integrity is disrupted in sporadic Alzheimer's disease, and network properties show ...
  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease 
    Barthélemy, Nicolas R.; Li, Yan; Joseph-Mathurin, Nelly; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Buckles, Virginia; Fagan, Anne M.; Perrin, Richard J.; Goate, Alison M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Berman, Sarah B.; Ikeuchi, Takeshi; Mori, Hiroshi; Shimada, Hiroyuki; Shoji, Mikio; Suzuki, Kazushi; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Graff-Radford, Neill R.; Salloway, Stephen; Schofield, Peter R.; Masters, Colin L.; Martins, Ralph N.; O’Connor, Antoinette; Fox, Nick C.; Levin, Johannes; Jucker, Mathias; Gabelle, Audrey; Lehmann, Sylvain; Sato, Chihiro; Bateman, Randall J.; McDade, Eric; Dominantly Inherited Alzheimer Network (Nature, 2020-03)
    Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal ...