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Browsing by Author "Xiong, Chengjie"

Browsing by Author "Xiong, Chengjie"

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  • Schultz, Stephanie A.; Allegri, Ricardo Francisco; Schultz, Aaron P.; Goate, Alison M.; Levey, Allan I.; Fagan, Anne M.; Hanseeuw, Bernard J.; Koeppe, Robert A.; Gordon, Brian A.; Cruchaga, Carlos; Karch, Celeste M.; Chen, Charles D.; Xiong, Chengjie; Jack Jr, Clifford R.; Fitzpatrick, Colleen D.; McDade, Eric; Chui, Helena C.; Mori, Hiroshi; Lee, Jae-Hong; Noble, James M. (Wiley, 2022-12)
    Background Rates of cognitive and biomarker change in Autosomal Dominant Alzheimer disease (ADAD) vary substantially across individuals. Prior cross-sectional work suggests that the location of the pathogenic variant ...
  • Millar, Peter R.; Gordon, Brian A.; Wisch, Julie K.; Schultz, Stephanie A.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Hassenstab, Jason J.; Ibanez, Laura; Karch, Celeste M.; Llibre Guerra, Jorge J.; Morris, John C.; Perrin, Richard J.; Supnet Bell, Charlene; Xiong, Chengjie; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Day, Gregory S.; Dominantly Inherited Alzheimer Network (BioMed Central, 2023-12-19)
    Background: "Brain-predicted age" estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease ...
  • Llibre Guerra, Jorge J.; Li, H; Schindler, Suzanne E.; Gordon, Brian A.; Fagan, Anne M.; Morris, John C.; Benzinger, Tammie L.S.; Hassenstab, Jason; Wang, Guoquiao; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Farlow, Martin R.; Holtzman, David M.; Jucker, Mathias; Levin, Johannes; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Karch, Celeste M.; Fox, Nick C.; Xiong, Chengjie; Bateman, Randall J.; McDade, Eric (American Medical Association, 2019-12-02)
    The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. ...
  • Morris, John C.; Weiner, Michael W.; Xiong, Chengjie; Beckett, Laurel A.; Coble, Dean; Saito, Naomi; Aisen, Paul S.; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Cairns, Nigel; Carrillo, María C.; Chui, Helena C.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Fagan, Anne M.; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Goate, Alison M. (Oxford University Press, 2022-10-21)
    The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of 'sporadic' late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings ...
  • Aschenbrenner, Andrew J.; James, Bryan D.; McDade, Eric; Wang, Guoquiao; Lim, Yen Ying; Benzinger, Tammie L.S.; Cruchaga, Carlos; Goate, Alison M.; Xiong, Chengjie; Perrin, Richard J.; Buckles, Virginia; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Fagan, Anne M.; Farlow, Martin R.; O’Connor, Antoinette; Ghetti, Bernardino; Graff-Radford, Neill R.; Goldman, Jill; Gräber, Susanne; Karch, Celeste M.; Lee, Jae-Hong; Levin, Johannes; Martins, Ralph N.; Masters, Colin L.; Mori, Hiroshi; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Morris, John C.; Bateman, Randall J.; Hassenstab, Jason; Dominantly Inherited Alzheimer Network; Dominantly Inherited Alzheimer Network (Wiley, 2020-06)
    Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is ...
  • Johnson, Erik C. B.; Bian, Shijia; Haque, Rafi U.; Carter, E. Kathleen; Watson, Caroline M.; Gordon, Brian A.; Ping, Lingyan; Duong, Duc M.; Epstein, Michael P.; McDade, Eric; Barthélemy, Nicolas R.; Karch, Celeste M.; Xiong, Chengjie; Cruchaga, Carlos; Perrin, Richard J.; Wingo, Aliza P.; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2023-08-07)
    Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into ...
  • Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.S.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison M.; Buckles, Virginia; Fox, Nick C.; Rossor, Martin N.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Ringman, John M.; Höglinger, Günter; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes; Dominantly Inherited Alzheimer Network (Oxford, 2019-03-20)
    Owing to an early and marked deposition of amyloid-β in the basal ganglia, autosomal dominant Alzheimer’s disease could distinctly involve motor symptoms. Therefore, we aimed to assess the prevalence and characteristics ...
  • Allegri, Ricardo Francisco; Dincer, Aylin; Gordon, Brian A.; Hari-Raj, Amrita; Keefe, Sarah J.; Flores, Shaney; McKay, Nicole S.; Paulick, Angela M.; Shady Lewis, Kristine E.; Feldman, Rebecca L.; Hornbeck, Russ C.; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Farlow, Martin R.; La Fougère, Christian; Fox, Nick C.; Fulham, Michael J.; Jack Jr, Clifford R.; Joseph-Mathurin, Nelly; Karch, Celeste M.; Lee, Athene; Levin, Johannes; Masters, Colin L.; McDade, Eric; Oh, Hwamee; Perrin, Richard J.; Raji, Cyrus; Salloway, Stephen; Schofield, Peter R.; Su, Yi; Villemagne, Victor L.; Wang, Qing; Weiner, Michael W.; Xiong, Chengjie; Yakushev, Igor; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L.S.; Dominantly Inherited Alzheimer Network (Elsevier, 2020-11-05)
    Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
  • Fagan, Anne M.; Henson, Rachel L.; Li, Yan; Boerwinkle, Anna H.; Xiong, Chengjie; Bateman, Randall J.; Goate, Alison M.; Ances, Beau M.; Doran, Eric; Christian, Bradley T.; Lai, Florence; Rosas, H. Diana; Schupf, Nicole; Krinsky-McHale, Sharon; Silverman, Wayne; Lee, Joseph H.; Klunk, William E.; Handen, Benjamin L.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network (Elsevier, 2021-08)
    Background Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at ...
  • Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • Buckles, Virginia; Xiong, Chengjie; Bateman, Randall J.; Hassenstab, Jason; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Danek, Adrian; Fagan, Anne M.; Ghetti, Bernardino; Goate, Alison M.; Graff-Radford, Neill R.; Jucker, Mathias; Levin, Johannes; Marcus, Daniel S.; Masters, Colin L.; McCue, Lena M.; McDade, Eric; Mori, Hiroshi; Moulder, Krista L. (John Wiley & Sons, 2021-12-02)
    As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine ...
  • Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack Jr, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network and the Alzheimer’s Disease Neuroimaging Initiative (American Medical Association, 2023-12-01)
    Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains ...
  • O'Connor, Antoinette; Rice, Helen; Barnes, Josephine; Ryan, Natalie S.; Liu, Kathy Y.; Allegri, Ricardo Francisco; Berman, Sarah B.; Ringman, John M.; Cruchaga, Carlos; Farlow, Martin R.; Hassenstab, Jason; Lee, Jae-Hong; Perrin, Richard J.; Xiong, Chengjie; Gordon, Brian A.; Levey, Allan I.; Goate, Alison M.; Graff-Radford, Neill R.; Levin, Johannes; Dominantly Inherited Alzheimer Network (BMJ Publishing Group, 2022-12-15)
  • Barthélemy, Nicolas R.; Li, Yan; Joseph-Mathurin, Nelly; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Buckles, Virginia; Fagan, Anne M.; Perrin, Richard J.; Goate, Alison M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Berman, Sarah B.; Ikeuchi, Takeshi; Mori, Hiroshi; Shimada, Hiroyuki; Shoji, Mikio; Suzuki, Kazushi; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Graff-Radford, Neill R.; Salloway, Stephen; Schofield, Peter R.; Masters, Colin L.; Martins, Ralph N.; O’Connor, Antoinette; Fox, Nick C.; Levin, Johannes; Jucker, Mathias; Gabelle, Audrey; Lehmann, Sylvain; Sato, Chihiro; Bateman, Randall J.; McDade, Eric; Dominantly Inherited Alzheimer Network (Nature, 2020-03)
    Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal ...

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