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Listar por tema "tau Proteins"

Listar por tema "tau Proteins"

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  • A biological classification for Alzheimer’s disease - Amyloid, Tau and Neurodegeneration (A/T/N): results from the Argentine-Alzheimer’s Disease Neuroimaging Initiative 
    Allegri, Ricardo Francisco; Pertierra, Lucía; Cohen, Gabriela; Chrem Méndez, Patricio Alexis; Russo, María Julieta; Calandri, Ismael Luis; Bagnati, Pablo M.; Tapajóz Pereira de Sampaio, Fernanda; Clarens, María Florencia; Campos, Jorge; Nahas, Federico Ezequiel; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio (Cambridge University Press, 2019-03-12)
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 
    Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)
    We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...
  • New landscape of the diagnosis of Alzheimer's disease 
    Frisoni, Giovanni B.; Hansson, Oskar; Nichols, Emma; Garibotto, Valentina; Schindler, Suzanne E.; van der Flier, Wiesje M.; Jessen, Frank; Villain, Nicolas; Arenaza-Urquijo, Eider M.; Crivelli, Lucia; Fortea, Juan; Grinberg, Lea T.; Ismail, Zahinoor; Minoshima, Satoshi; Ossenkoppele, Rik; Zetterberg, Henrik; Petersen, Ronald C.; Dubois, Bruno (Elsevier, 2025-09-22)
    Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading ...
  • Serial-position effect as a biomarker in the diferential diagnosis of mild cognitive impairment. A multimodal biomarkers aproach. (P3.1-018) 
    Calandri, Ismael Luis; Martin, María Eugenia; Chrem Méndez, Patricio Alexis; Helou, María Belén; Clarens, María Florencia; Crivelli, Lucía; Allegri, Ricardo Francisco (Lippincott Williams & Wilkins, 2019-04-09)
    Objective: To study the serial-position effect in a hippocampal disease as early stages of Alzheimer’s disease. Background: The serial-position effect, present in the learning of lists of words, is divided in primacy ...
  • SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy 
    Muñiz, Javier Andrés; Facal, Carolina Lucía; Urrutia, Leandro; Clerici Delville, Ramiro; Damianich, Ana; Ferrario, Juan Esteban; Falasco, Germán; Avale, María Elena (Frontiers Media S.A., 2022-09-05)
    Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, ...
  • Survey among experts on the future role of tau-PET in clinical practice and trials 
    Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley on behalf of the Alzheimer's Association, 2024)
    Background: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the ...
  • Tau mis-splicing correlates with motor impairments and striatal dysfunction in a model of tauopathy 
    Damianich, Ana; Facal, Carolina Lucía; Muñiz, Javier Andrés; Mininni, Camilo; Soiza Reilly, Mariano; Ponce de León, Magdalena; Urrutia, Leandro; Falasco, Germán; Ferrario, Juan Esteban; Avale, María Elena (Oxford, 2021-06-01)
    Tauopathies are neurodegenerative diseases caused by the abnormal metabolism of the microtubule associated protein Tau, which is highly expressed in neurons and critically involved in microtubule dynamics. In the adult ...
  • The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology 
    McDade, Eric; Barthélemy, Nicolas R.; Wang, Guoqiao; Li, Yan; Cao, Yuchen; Gordon, Brian; Benzinger, Tammie L. S.; Clifford, David; Goate, Alison M.; Renton, Alan E.; Hassenstab, Jason; Llibre-Guerra, Jorge J.; Perrin, Richard J.; Xiong, Chengjie; Cruchaga, Carlos; Mummery, Catherine J.; Berman, Sarah B.; Lah, James; Chrem Méndez, Patricio Alexis; DIAN‐TU Study Team and DIAN Obs Team (Wiley, 2025-09-23)
    Background: Tau-derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid-beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long-term anti-Aβ antibodies on amyloid ...