DSpace Repositorium (Manakin basiert)

Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: Insights from task-based and resting-state fMRI

Zur Kurzanzeige

dc.contributor.author Fajardo Valdez, Alfonso
dc.contributor.author Camacho Téllez, Vicente
dc.contributor.author Rodríguez Cruces, Raúl
dc.contributor.author García Gomar, María Luisa
dc.contributor.author Pasaye, Erick Humberto
dc.contributor.author Concha, Luis
dc.date.accessioned 2024-04-15T12:43:21Z
dc.date.available 2024-04-15T12:43:21Z
dc.date.issued 2024-03-13
dc.identifier.citation Fajardo-Valdez A, Camacho-Téllez V, Rodríguez-Cruces R, García-Gomar ML, Pasaye EH, Concha L. Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: Insights from task-based and resting-state fMRI. PLoS One. 2024 Mar 13;19(3):e0295142. doi: 10.1371/journal.pone.0295142. es_ES
dc.identifier.uri https://doi.org/10.1371/journal.pone.0295142
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1072
dc.description.abstract Temporal lobe epilepsy (TLE) is a common form of medically intractable epilepsy. Although seizures originate in mesial temporal structures, there are widespread abnormalities of gray and white matter beyond the temporal lobes that negatively impact functional networks and cognition. Previous studies have focused either on the global impact on functional networks, or on the functional correlates of specific cognitive abilities. Here, we use a two-pronged approach to evaluate the link between whole-brain functional connectivity (FC) anomalies to overall cognitive performance, and how such abnormal connectivity alters the fronto-parietal brain regions involved in working memory (WMem), a cognitive disability often reported by TLE patients. We evaluated 31 TLE patients and 35 healthy subjects through extensive cognitive testing, resting-state functional magnetic resonance imaging (RS-fMRI), and task-based fMRI using Sternberg's task to evaluate WMem. As a group, TLE patients displayed cognitive abnormalities across different domains, although considerable within-group variability was identified. TLE patients showed disruptions of functional networks between and within the default mode network (DMN) and task-positive networks (TPN) resulting in associations with cognitive performance. Furthermore, during the WMem task, TLE patients showed abnormal activity of fronto-parietal regions that were associated with other forms of memory, and alterations of seed-based connectivity analyses. Our results show that different degrees of abnormal functional brain activity and connectivity are related to the severity of disabilities across cognitive spheres. Differential co-activation patterns between patients and healthy subjects suggest potential compensatory mechanisms to preserve adequate cognitive performance. es_ES
dc.description.abstract Servicio de Psiquiatría
dc.language.iso eng es_ES
dc.publisher Public Library of Science es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Epilepsia del Lóbulo Temporal es_ES
dc.subject Epilepsy, Temporal Lobe es_ES
dc.subject Imagen por Resonancia Magnética es_ES
dc.subject Magnetic Resonance Imaging es_ES
dc.subject Pruebas Neuropsicológicas es_ES
dc.subject Neuropsychological Tests es_ES
dc.title Functional correlates of cognitive performance and working memory in temporal lobe epilepsy: Insights from task-based and resting-state fMRI es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.relation.ispartofVOLUME 19
dc.relation.ispartofNUMBER 3
dc.relation.ispartofPAGINATION e0295142
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY San Francisco
dc.relation.ispartofTITLE PloS one
dc.relation.ispartofISSN 1932-6203
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Dateien zu dieser Ressource

Das Dokument erscheint in:

Zur Kurzanzeige

DSpace Suche


Stöbern

Mein Benutzerkonto

Statistik