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dc.contributor.author Antoniol, María Noelia
dc.contributor.author Moreno, Pedro J.
dc.contributor.author Milisenda, José C.
dc.contributor.author Selva O'Callaghan, Albert
dc.contributor.author Grau, Josep María
dc.contributor.author Padrosa, Joan
dc.date.accessioned 2020-11-05T14:06:14Z
dc.date.available 2020-11-05T14:06:14Z
dc.date.issued 2020-05-04
dc.identifier.citation Antoniol, M.N., Moreno, P.J., Milisenda, J.C., Selva O’Callaghan, A., Grau, J.M., Padrosa, J., 2020. Statin use and myopathy. Not always guilty. Rheumatology (Oxford). https://doi.org/10.1093/rheumatology/keaa180 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/221
dc.identifier.uri https://doi.org/10.1093/rheumatology/keaa180
dc.description.abstract Objectives. Statins are the cornerstone of the treatment and prevention of cardiovascular disease but have been associated with muscular side effects, among others. If patients are not properly evaluated, statin discontinuation may take place, leaving patients’ symptoms unresolved and precluding an effective cardiovascular treatment. The present study aims to describe the clinical characteristics, the diagnostic process and the final diagnosis of selected patients with suspected statin-induced myopathy, with quite different alternative diagnoses. Methods. Among the 86 patients referred to our unit for evaluation since 2012, 6 patients with suspected statininduced myopathy that was finally ruled out were selected as examples because of their illustrative value. All patients were evaluated in a Muscular Diseases Unit by myology experts, and additional testing was performed according to clinical suspicion. Results. Of the six selected patients with suspected statin-induced myopathy, three had a neurogenic aetiology, two had vacuolar myopathies and one had severe hypothyroidism. Statins were permanently discontinued in two cases, with the treatment of one of the latter patients being continued with a protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Conclusion. Not all patients taking statins who develop muscle complaints have statin-related myopathy. A thorough clinical evaluation and appropriate testing is warranted to avoid an unnecessary increase in cardiovascular risk. en_US
dc.language.iso eng en_US
dc.publisher Oxford University Press en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Neuromuscular Diseases en_US
dc.subject Enfermedades Neuromusculares en_US
dc.subject Statin en_US
dc.title Statin use and myopathy. Not always guilty. en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Antoniol, María Noelia. Fleni. Departamento de Medicina Interna. Sección de Reumatología; Argentina.
dc.description.fil Fil: Moreno, Pedro J. Hospital Clínic de Barcelona. Internal Medicine Department. Muscle Research Unit; España. Universidad de Barcelona. Center for Biomedical Research on Rare Diseases; España.
dc.description.fil Fil: Milisenda, José C. Hospital Clínic de Barcelona. Internal Medicine Department. Muscle Research Unit; España. Universidad de Barcelona. Center for Biomedical Research on Rare Diseases; España.
dc.description.fil Fil: Selva O’Callaghan, Albert. Hospital Vall d'Hebron. Internal Medicine Department; España.
dc.description.fil Fil: Grau, Josep María. Hospital Clínic de Barcelona. Internal Medicine Department. Muscle Research Unit; España. Universidad de Barcelona. Center for Biomedical Research on Rare Diseases; España.
dc.description.fil Fil: Padrosa, Joan. Hospital Clínic de Barcelona. Internal Medicine Department. Muscle Research Unit; España. Universidad de Barcelona. Center for Biomedical Research on Rare Diseases; España.
dc.relation.ispartofPAGINATION keaa180
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofTITLE Rheumatology (Oxford)
dc.relation.ispartofISSN 1462-0332
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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