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Pituicytoma Associated with Acromegaly and Cushing Disease

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dc.contributor.author Marcó Del Pont, Francisco
dc.contributor.author Villalonga, Juan Francisco
dc.contributor.author Ries Centeno, Tomás
dc.contributor.author Arakaki, Naomi
dc.contributor.author Katz, Débora Adela
dc.contributor.author Cervio, Andrés Eduardo
dc.date.accessioned 2020-12-29T12:29:13Z
dc.date.available 2020-12-29T12:29:13Z
dc.date.issued 2020-04
dc.identifier.citation Marco Del Pont, F., Villalonga, J.F., Ries-Centeno, T., Arakaki, N., Katz, D., Cervio, A., 2020. Pituicytoma Associated with Acromegaly and Cushing Disease. World Neurosurg 136, 78–82. https://doi.org/10.1016/j.wneu.2019.12.085 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/287
dc.identifier.uri https://doi.org/10.1016/j.wneu.2019.12.085
dc.description.abstract Background: Pituicytoma is a rare neoplasm arising in the sellar region (World Health Organization grade I). Clinically, pituicytomas mimic nonfunctioning pituitary macroadenomas and are occasionally incidentally discovered at autopsy. Pituitary adenomas can occur with other sellar pathologies, and the term "collision sellar lesions" has been coined for this rare entity. There have only been a few reports of the coexistence of pituicytoma and pituitary adenoma. We present 2 cases of pituicytoma coexisting with acromegaly and Cushing disease. Case description: Case 1: A 29-year-old woman had acromegaly. The macroadenoma was partially removed in her first surgery; thus an endonasal reoperation was required for debulking and posterior radiosurgery. Pituicytoma coexisting with somatotropinoma was diagnosed on pathologic examination. Case 2: A 33-year-old woman had adrenocorticotropic hormone-dependent Cushing disease. She underwent endonasal resection. Undetectable postoperative cortisol levels provided evidence that the underlying adrenocorticotropic hormone source was successfully removed. On the basis of morphologic features and the immunohistochemical profile, pituicytoma was diagnosed on pathologic examination. Pituitary adenoma was not confirmed histologically in this patient. Conclusions: Only 117 cases of pituicytoma have been reported since it was first described in 1955. Before our report, only 5 cases of patients with pituicytoma coexisting with pituitary adenoma had been described. The coexistence of these 2 entities may not just be a mere coincidence but may be due to a yet unknown pathophysiologic link or common progenitor lineage of both lesions. Association between pituicytoma and pituitary adenoma is increasingly being reported. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Acromegaly en_US
dc.subject Acromegalia en_US
dc.subject Cushing Syndrome en_US
dc.subject Síndrome de Cushing en_US
dc.subject Pituitary Neoplasms en_US
dc.subject Neoplasias Hipofisarias en_US
dc.title Pituicytoma Associated with Acromegaly and Cushing Disease en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Marcó Del Pont, Francisco. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Villalonga, Juan Francisco. Universidad Nacional de Tucumán. Facultad de Medicina. LINT; Argentina.
dc.description.fil Fil: Ries Centeno, Tomás. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Arakaki, Naomi. Fleni. Departamento de Neuropatología y Biología Molecular; Argentina.
dc.description.fil Fil: Katz, Débora Adela. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Cervio, Andrés Eduardo. Fleni. Departamento de Neurocirugía; Argentina.
dc.relation.ispartofVOLUME 136
dc.relation.ispartofPAGINATION 78-82
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE World neurosurgery
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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