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dc.contributor.author | Tao, Pengyou | |
dc.contributor.author | Perrone, Sofía | |
dc.contributor.author | Demarchi, Gianina | |
dc.contributor.author | Chimento, Agustina | |
dc.contributor.author | Cervio, Andrés Eduardo | |
dc.contributor.author | Sevlever, Gustavo Emilio | |
dc.contributor.author | Berner, Silvia Inés | |
dc.contributor.author | Becu-Villalobos, Damasia | |
dc.contributor.author | Basso, Armando | |
dc.contributor.author | Ge, Chen | |
dc.contributor.author | Ling, Feng | |
dc.contributor.author | Zhang, Qiuhang | |
dc.contributor.author | Cristina, Carolina | |
dc.date.accessioned | 2021-02-04T14:00:12Z | |
dc.date.available | 2021-02-04T14:00:12Z | |
dc.date.issued | 2021-01-20 | |
dc.identifier.citation | Tao P, Perrone S, Demarchi G, Chimento A, Cervio A, Sevlever GE, Berner SI, Becu-Villalobos D, Basso A, Ge C, Ling F, Zhang Q, Cristina C. Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors. A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness. En Research Square. 2021 Ene 20. doi: 10.21203/rs.3.rs-150356/v1 | en_US |
dc.identifier.uri | https://doi.org/10.21203/rs.3.rs-150356/v1 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/handle/123456789/358 | |
dc.description.abstract | Background: Pituitary adenomas can become invasive and aggressive, and in turn produce tumor recurrence. Endocan or endothelial cell specific molecule-1 (ESM1) has been associated with angiogenesis and tumor growth in gliomas, and lung, kidney, liver among other cancers, but there is a scarcity of information regarding its role in pituitary adenomas. In the search for biomarkers of tumor behavior our objective was to determine the relationship between endocan (ESM1) mRNA expression and cavernous sinus invasion, and its association with gene expression of VEGF, FGF2 and PDGF angiogenic factors in human pituitary adenomas. Methods: ESM1, VEGF, FGF2 and PDGF expression was determined by qRT-PCR in 28 pituitary tumor samples and tumor invasion was determined by the Knosp grade classification. Results were associated with clinical data. Results: We found that ESM1 was expressed in 75% of the tumors. FGF2 expression was higher in ESM1-positive compared to ESM1-negative tumors, and a significant negative correlation in the expression of FGF2 and PDGF was found. Although ESM1 expression did not show any differences in invasive and non-invasive tumors, a positive correlation between ESM1 and Knosp grade was reached when grade 0-3 tumors were considered, suggesting its participation in the initial periods of tumor invasion. Finally, no difference in ESM1 expression was found between functioning and non-functioning adenomas, or patients age. Conclusions: Our study points to a precise pattern of angiogenic factor expression in pituitary tumors, and its relation to invasive behavior, which should be considered in the tailoring of drug treatments for aggressive and resistant pituitary adenomas. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Research Square | en_US |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Angiogenesis | en_US |
dc.subject | ESM1 protein, human | en_US |
dc.subject | Pituitary Neoplasms | en_US |
dc.subject | Neoplasias Hipofisarias | en_US |
dc.subject | Receptors, Platelet-Derived Growth Factor | en_US |
dc.subject | Receptores del Factor de Crecimiento Derivado de Plaquetas | en_US |
dc.subject | Receptors, Fibroblast Growth Factor | en_US |
dc.subject | Receptores de Factores de Crecimiento de Fibroblastos | en_US |
dc.title | Endocan, VEGF, FGF2 and PDGF Expression in Pituitary Tumors. A Precise Angiogenic Marker Relationship in the Context of Tumor Invasiveness | en_US |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.type | info:eu-repo/semantics/article | en_US |
dc.description.fil | Fil: Tao, Pengyou. Xuanwu Hospital; China. | |
dc.description.fil | Fil: Perrone, Sofía. UNNOBA; Argentina. | |
dc.description.fil | Fil: Demarchi, Gianina. UNNOBA; Argentina. | |
dc.description.fil | Fil: Chimento, Agustina. UNNOBA; Argentina. | |
dc.description.fil | Fil: Cervio, Andrés Eduardo. Fleni. Departamento de Neurocirugía; Argentina. | |
dc.description.fil | Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular; Argentina. | |
dc.description.fil | Fil: Berner, Silvia Inés. Clinica Santa Isabel. Servicio de Neurocirugia; Argentina. | |
dc.description.fil | Fil: Becu-Villalobos, Damasia. Instituto de Biología y Medicina Experimental; Argentina. | |
dc.description.fil | Fil: Basso, Armando. Fundación de Neurociencias Aplicadas; Argentina. | |
dc.description.fil | Fil: Ge, Chen. Xuanwu Hospital; China. | |
dc.description.fil | Fil: Ling, Feng. Xuanwu Hospital; China. | |
dc.description.fil | Fil: Zhang, Qiuhang. Xuanwu Hospital; China. | |
dc.description.fil | Fil: Cristina, Carolina. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina. | |
dc.relation.ispartofTITLE | Research Square | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |