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Risk factors for respiratory failure among hospitalized patients with Guillain-Barré syndrome

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dc.contributor.author Maskin, Luis Patricio
dc.contributor.author Wilken, Miguel
dc.contributor.author Rodríguez Lucci, Federico
dc.contributor.author Wisnivesky, J. P.
dc.contributor.author Barroso, Fabio Adrián
dc.contributor.author Wainsztein, Néstor Adrián
dc.date.accessioned 2021-06-16T13:38:26Z
dc.date.available 2021-06-16T13:38:26Z
dc.date.issued 2021-05-30
dc.identifier.citation Maskin LP, Wilken M, Rodriguez Lucci F, Wisnivesky JP, Barroso F, Wainsztein N. Risk factors for respiratory failure among hospitalized patients with Guillain-Barré syndrome. Neurologia. 2021 May 29:S0213-4853(21)00082-7. English, Spanish. doi: 10.1016/j.nrl.2021.04.011 es_ES
dc.identifier.uri https://doi.org/10.1016/j.nrl.2021.04.011
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/495
dc.description.abstract Background: Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy that can lead to respiratory failure. In this study, we evaluate early clinical risk factors for respiratory failure at the time of hospital admission. Methods: We studied a retrospective cohort of patients with GBS admitted to a tertiary care center. The potential risk factors studied were sociodemographic characteristics, GBS symptoms, overall and cervical muscle weakness (Medical Research Council [MRC] scores), electromyography findings, and cerebrospinal fluid analysis findings. Unadjusted odds ratios (OR) were calculated and exact logistic regression analysis (adjusted OR) performed to assess the association between baseline risk factors and respiratory failure. Results: Overall, 13 of 113 (12%) patients included in the study developed respiratory failure. Unadjusted analyses showed that involvement of any cranial nerve (OR: 14.7; 95% CI, 1.8-117.1), facial palsy (OR: 17.3; 95% CI, 2.2-138.0), and bulbar weakness (OR: 10.7; 95% CI, 2.3-50.0) were associated with increased risk of respiratory failure. Lower MRC sum scores (for scores <30, OR: 14.0; 95% CI, 1.54-127.2) and neck MRC scores (for scores ≤3, OR: 21.0; 95% CI, 3.5-125.2) were associated with higher likelihood of respiratory failure. Adjusted analyses showed that presence of bulbar weakness (OR: 7.6; 95% CI, 1.3-43.0) and low neck MRC scores (scores ≤3, OR: 9.2; 95% CI, 3.5-125.2, vs scores >3) were independently associated with respiratory failure. Conclusions: Bulbar and neck muscle weakness at admission are clinical predictors of increased risk of respiratory failure in patients with GBS. These findings could guide the adequate management of high-risk patients. es_ES
dc.language.iso spa es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Guillain-Barre Syndrome es_ES
dc.subject Síndrome de Gillain Barre es_ES
dc.subject Respiratory Insufficiency es_ES
dc.subject Insuficiencia Respiratoria es_ES
dc.subject Hospitalization es_ES
dc.subject Hospitalización es_ES
dc.title Risk factors for respiratory failure among hospitalized patients with Guillain-Barré syndrome es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Maskin, Luis Patricio. Fleni. Departamento de Medicina Interna; Argentina.
dc.description.fil Fil: Wilken, Miguel. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Rodríguez Lucci, Federico. Fleni. Departamento de Medicina Interna; Argentina.
dc.description.fil Fil: Wisnivesky, J. P. Icahn School of Medicine at Mount Sinai; Estados Unidos.
dc.description.fil Fil: Barroso, Fabio Adrián. Fleni. Departamento de Neurología. Sección de Enfermedades Neuromusculares; Argentina.
dc.description.fil Fil: Wainsztein, Néstor Adrián. Fleni. Departamento de Medicina Interna; Argentina.
dc.relation.ispartofCOUNTRY España
dc.relation.ispartofCITY Barcelona
dc.relation.ispartofTITLE Neurología
dc.relation.ispartofISSN 1578-1968
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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