DSpace Repositorium (Manakin basiert)

The antiphospholipid antibodies registry of the Argentinean Society of Rheumatology (GESAF-SAR): baseline data of the first 162 patients

Zur Kurzanzeige

dc.contributor.author Nieto, Romina
dc.contributor.author Serrano, Rosa
dc.contributor.author Savio, Verónica
dc.contributor.author Lema, Luis Roberto
dc.contributor.author Maldini, Carla
dc.contributor.author Perés, Silvia
dc.contributor.author Izaguirre, Pia
dc.contributor.author Bellomio, Verónica
dc.contributor.author Leguizamón, Maria Lilia
dc.contributor.author Sacnun, Mónica
dc.contributor.author Estevez, Adrián
dc.contributor.author Avalo, Alejandra
dc.contributor.author Etcheverri, Maira
dc.contributor.author Antoniol, María Noelia
dc.contributor.author Perandones, Carlos Edgardo
dc.contributor.author Goizueta, Cecilia
dc.contributor.author Lobo, Victoria
dc.contributor.author Gobbi, Carla
dc.contributor.author Artesana, Pablo
dc.date.accessioned 2021-08-23T12:37:56Z
dc.date.available 2021-08-23T12:37:56Z
dc.date.issued 2020-04
dc.identifier.citation Porta A, Nieto R, Serrano R, Savio V, Lema L, Maldini C, Perés S, Izaguirre P, Bellomio V, Leguizamón ML, Sacnun M, Estevez A, Avalo A, Etcheverri M, Antoniol MN, Perandones C, Goizueta C, Lobo V, Gobbi C, Artesana P, Cucchiaro N, Vivero F, Bastita M, Saurit V, Riscanevo N, Pissoni C, De la Torre, ML, Machado Escobar M, Danielsen MC, Remondino G, Neman V, Benzaquen N, Babini A, Funes C, Roberts K, Guaglianone D, Gómez G, Pérez N, Berman H, Alba P, Pons Estel G. The antiphospholipid antibodies registry of the Argentinean Society of Rheumatology (GESAF-SAR): baseline data of the first 162 patients. Journal of Clinical Rheumatology April 2020 - Volume 26 - Issue 3S - p S1-S150 doi: 10.1097/RHU.0000000000001389. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/556
dc.identifier.uri https://journals.lww.com/jclinrheum/Fulltext/2020/04001/22nd_PANLAR_Congress__Miami,_FL,_August_12_15_2020.1.aspx
dc.description.abstract Objective: Antiphospholipid antibodies registry of the Argentinean Society of Rheumatology (GESAF-SAR) was created to study long-term disease characteristics and outcomes in persistently antiphospholipid antibody (aPL)-positive patients. The objective was to report baseline demographic, clinical, laboratory and treatment characteristics of aPL-positive patients enrolled in the registry. Materials and Methods: GESAF-SAR is a multicenter, multidisciplinary and longitudinal study. Thirty centers from Argentina participated. Data collection was performed by review of medical records and interview with individuals/patients, after signing an informed consent. A web-based data capture system (ARTHROS) was used. Inclusion criteria: aPL with at least one positive determination of Lupus Anticoagulant (LAC) and/or positive Anticardiolipin Antibodies (aCL) and Anti-βeta 2 Glycoprotein I (aβ2GLPI) IgG and IgM greater 40 or positive aCL and/or aβ2GLPI with levels 20-40 GPL or MPL (at least two determinations) separated by 12 weeks. Patients were followed every 12±3 months. Descriptive cross-sectional analysis of data collected from May to October 2019 was performed. Results: Overall 162 patients were enrolled, 139 (86%) were women with a mean age at entry of 40.3 years (SD 12.9); 76 (47%) patients were Mestizo, 72 (44%) Caucasians and 14 (9%) others. The socioeconomic level was Medium-Low in 47 patients (29%), Medium in 58 (36%) and Medium-High in 25 (15%). Seventy-four patients (46%) met classification criteria for Primary APS, 37 (23%) were APS associated with autoimmune disease and 2 (1%) were catastrophic APS (CAPS). Of the 111 APS patients, 50 (45%) presented thrombotic manifestations, 44 (40%) obstetric and 16 (15%) both. Forty-nine patients (30%) did not meet classification criteria of APS. A total of 40 (24.7%) venous events, 34 (21%) arterial, 70 (43.2%) obstetric morbidity and 55 (34%) non-criteria manifestations were recorded. Seventy-seven women presented at least one pregnancy with a total 265 gestations, resulting in 104 (39%) live births. Of all gestations, 80 (30%) were miscarriages <10 weeks, 53 (20%) premature births, 42 (16%) placental insufficiency, 24 (9%) preeclampsia and only 2 (1%) eclampsia. Based on aPL profile, 88 (54%) were positive for LAC, 110 (68%) aCL and 74 (46%) for aβ2GLPI. Regarding treatments, 117 (72%) patients received Aspirin, 71 (43.8%) oral anticoagulation, 53 (32.7%) prophylactic heparin, 46 (28.4%) therapeutic heparin, 92 (56.8%) hydroxychloroquine. Conclusions: In our multi-center Argentinean aPL-positive cohort, at baseline: a) 30% of patients did not meet classification criteria of APS, b) 46% met classification criteria for Primary APS, c) one-fourth were APS associated with autoimmune disease, d) 45% presented thrombotic manifestations, e) the most frequent obstetric morbidity were miscarriages <10 weeks. Future longitudinal analysis of GESAF-SAR Registry will help clarify the risk profiles of aPL in Argentina.
dc.language.iso eng es_ES
dc.publisher Williams & Wilkins es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Antibodies, Antiphospholipid es_ES
dc.subject Anticuerpos Antifosfolípidos es_ES
dc.subject Rheumatology es_ES
dc.subject Reumatología es_ES
dc.title The antiphospholipid antibodies registry of the Argentinean Society of Rheumatology (GESAF-SAR): baseline data of the first 162 patients es_ES
dc.type info:eu-repo/semantics/other es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Antoniol, María Noelia. Fleni. Departamento de Medicina Interna. Sección de Reumatología; Argentina.
dc.description.fil Fil: Perandones, Carlos Edgardo. Fundación Favaloro; Argentina. Fleni. Departamento de Medicina Interna; Argentina.
dc.description.fil Fil: Porta, Sabrina. Hospital Ramos Mejia; Argentina. Centro Regional de Enfermedad Autoinmunes y Reumáticas; Argentina.
dc.description.fil Fil: Nieto, Romina. Hospital Ramos Mejia; Argentina. Hospital Provincial de Rosario; Argentina.
dc.description.fil Fil: Serrano, Rosa. Hospital Ramos Mejia; Argentina.
dc.description.fil Fil: Savio, Verónica. Hospital Córdoba; Argentina. Hospital Materno Neonatal; Argentina.
dc.description.fil Fil: Lema, Luis Roberto. Instituto Modelo de Cardiología; Argentina.
dc.description.fil Fil: Maldini, Carla. Instituto Modelo de Cardiología; Argentina.
dc.description.fil Fil: Perés, Silvia. Hospital Ramos Mejia; Argentina.
dc.description.fil Fil: Izaguirre, Pia. Hospital Ramos Mejia; Argentina.
dc.description.fil Fil: Bellomio, Verónica. Hospital Ángel C. Padilla; Argentina.
dc.description.fil Fil: Leguizamón, Maria Lilia. Hospital Ángel C. Padilla; Argentina.
dc.description.fil Fil: Sacnun, Mónica. Hospital Provincial de Rosario; Argentina.
dc.description.fil Fil: Estevez, Adrián. Hospital El Cruce; Argentina.
dc.description.fil Fil: Avalo, Alejandra. Hospital El Cruce; Argentina.
dc.description.fil Fil: Etcheverri, Maira. Hospital El Cruce; Argentina.
dc.description.fil Fil: Goizueta, Cecilia. Sanatorio 9 de Julio; Argentina.
dc.description.fil Fil: Lobo, Victoria. Sanatorio 9 de Julio; Argentina.
dc.description.fil Fil: Gobbi, Carla. Sanatorio Allende; Argentina.
dc.description.fil Fil: Artesana, Pablo. Sanatorio Allende; Argentina.
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Dateien zu dieser Ressource

Das Dokument erscheint in:

Zur Kurzanzeige

info:eu-repo/semantics/openAccess Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: info:eu-repo/semantics/openAccess

DSpace Suche


Stöbern

Mein Benutzerkonto

Statistik