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The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database

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dc.contributor.author Vincent, Jean-Louis
dc.contributor.author Ferguson, Andrew
dc.contributor.author Pickkers, Peter
dc.contributor.author Jakob, Stephan M.
dc.contributor.author Jaschinski, Ulrich
dc.contributor.author Almekhlafi, Ghaleb A.
dc.contributor.author Leone, Marc
dc.contributor.author Mokhtari, Majid
dc.contributor.author Fontes, Luis E.
dc.contributor.author Bauer, Philippe R.
dc.contributor.author Sakr, Yasser
dc.contributor.author ICON Investigators
dc.contributor.author Wainsztein, Néstor Adrián
dc.date.accessioned 2021-08-24T15:03:25Z
dc.date.available 2021-08-24T15:03:25Z
dc.date.issued 2020-04-23
dc.identifier.citation Vincent JL, Ferguson A, Pickkers P, Jakob SM, Jaschinski U, Almekhlafi GA, Leone M, Mokhtari M, Fontes LE, Bauer PR, Sakr Y; ICON Investigators. The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database. Crit Care. 2020 Apr 23;24(1):171. doi: 10.1186/s13054-020-02858-x. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/560
dc.identifier.uri https://doi.org/10.1186/s13054-020-02858-x
dc.description.abstract Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output < 0.5 ml/kg/h) in acutely ill patients and its association with the need for renal replacement therapy (RRT) and outcome. Methods: International observational study. All adult (> 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient-oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged-oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent-oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome. es_ES
dc.language.iso eng es_ES
dc.publisher BioMed Central Ltd es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Oliguria es_ES
dc.subject Renal Replacement Therapy es_ES
dc.subject Terapia de Reemplazo Renal es_ES
dc.title The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Wainsztein, Néstor Adrián. Fleni. Departamento de Medicina Interna; Argentina.
dc.description.fil Fil: Vincent, Jean-Louis. Université Libre de Bruxelles. Erasme University Hospital. Department of Intensive Care; Bélgica.
dc.description.fil Fil: Ferguson, Andrew. Belfast City Hospital. Department of Intensive Care Medicine; Reino Unido.
dc.description.fil Fil: Pickkers, Peter. Radboud University Medical Center. Department of Intensive Care Medicine; Países Bajos.
dc.description.fil Fil: Jakob, Stephan M. University of Bern. University Hospital Bern. Department of Intensive Care Medicine; Suiza.
dc.description.fil Fil: Jaschinski, Ulrich. Universität Augsburg. Universitätsklinik Augsburg. Klinik für Anästhesiologie und Operative Intensivmedizin; Alemania.
dc.description.fil Fil: Almekhlafi, Ghaleb A. Prince Sultan Military Medical City. ICS Department; Arabia Saudita.
dc.description.fil Fil: Leone, Marc. Aix Marseille Université. Hôpital Nord. Service d'Anesthésie et de Réanimation; Francia.
dc.description.fil Fil: Mokhtari, Majid. SBMU. Department of Internal Medicine; Irán.
dc.description.fil Fil: Fontes, Luis E. Faculdade de Medicina de Petrópolis. Departamento de Medicina Baseada em Evidências, Medicina Intensiva, Urgência e Emergência; Brasil.
dc.description.fil Fil: Bauer, Philippe R. Mayo Clinic. Division of Pulmonary and Critical Care Medicine. Department of Internal Medicine; Estados Unidos.
dc.description.fil Fil: Sakr, Yasser. Uniklinikum Jena. Departament of Anaesthesiology and Intensive Care; Alemania.
dc.relation.ispartofVOLUME 24
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 171
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Critical care : the official journal of the Critical Care Forum
dc.relation.ispartofISSN 364-8535
dc.type.snrd info:ar-repo/semantics/artículo es_ES

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