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Empagliflozin in Heart Failure with a Preserved Ejection Fraction

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dc.contributor.author Anker, Stefan D.
dc.contributor.author Butler, Javed
dc.contributor.author Gerasimos, Filippatos
dc.contributor.author Ferreira, João Pedro
dc.contributor.author Bocchi, Edimar
dc.contributor.author Böhm, Michael
dc.contributor.author Brunner-La Rocca, Hans Pieter
dc.contributor.author Choi, Dong-Ju
dc.contributor.author Chopra, Vijay
dc.contributor.author Chuquiure-Valenzuela, Eduardo
dc.contributor.author Giannetti, Nadia
dc.contributor.author Gomez-Mesa, Juan Esteban
dc.contributor.author Janssens, Stefan
dc.contributor.author Januzzi, James L.
dc.contributor.author Gonzalez-Juanatey, Jose R.
dc.contributor.author Merkely, Bela
dc.contributor.author Nicholls, Stephen J.
dc.contributor.author Perrone, Sergio Víctor
dc.contributor.author Piña, Ileana L.
dc.contributor.author EMPEROR-Preserved Trial Investigators
dc.date.accessioned 2021-09-09T13:21:58Z
dc.date.available 2021-09-09T13:21:58Z
dc.date.issued 2021-08-27
dc.identifier.citation Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021 Aug 27. doi: 10.1056/NEJMoa2107038 es_ES
dc.identifier.uri https://doi.org/10.1056/NEJMoa2107038
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/582
dc.description.abstract Background: Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. Methods: In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. Results: Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin. Conclusions: Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes. (Funded by Boehringer Ingelheim and Eli Lilly; EMPEROR-Preserved ClinicalTrials.gov number, NCT03057951). es_ES
dc.language.iso eng es_ES
dc.publisher Massachusetts Medical Society es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Empagliflozin es_ES
dc.subject Empagliflozina es_ES
dc.subject Heart Failure es_ES
dc.subject Insuficiencia Cardíaca es_ES
dc.subject Stroke Volume es_ES
dc.subject Volumen Sistólico es_ES
dc.title Empagliflozin in Heart Failure with a Preserved Ejection Fraction es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Anker, Stefan D.. Charité Universitätsmedizin Berlin; Alemania.
dc.description.fil Fil: Butler, Javed. University of Mississippi Medical Center; Estados Unidos.
dc.description.fil Fil: Gerasimos, Filippatos. National and Kapodistrian University of Athens School of Medicine; Grecia.
dc.description.fil Fil: Ferreira, João Pedro. Université de Lorraine; Francia.
dc.description.fil Fil: Bocchi, Edimar. Universidade de São Paulo; Brasil.
dc.description.fil Fil: Böhm, Michael. Semmelweiss University; Hungría.
dc.description.fil Fil: Brunner-La Rocca, Hans Pieter. Maastricht University Medical Center; Holanda.
dc.description.fil Fil: Choi, Dong-Ju. Seoul National University Bundang Hospital; Corea.
dc.description.fil Fil: Chopra, Vijay. Max Superspeciality Hospital; India.
dc.description.fil Fil: Chuquiure-Valenzuela, Eduardo. National Institute of Cardiology; México.
dc.description.fil Fil: Giannetti, Nadia. McGill University Health Centre; Canadá.
dc.description.fil Fil: Gomez-Mesa, Juan Esteban. Universidad Icesi; Colombia.
dc.description.fil Fil: Janssens, Stefan. University Hospitals Leuven; Bélgica.
dc.description.fil Fil: Januzzi, James L. Massachusetts General Hospital; Estados Unidos.
dc.description.fil Fil: Gonzalez-Juanatey, Jose R. University Hospital; España.
dc.description.fil Fil: Merkely, Bela. Semmelweiss University; Hungría.
dc.description.fil Fil: Nicholls, Stephen J. Monash University; Australia.
dc.description.fil Fil: Perrone, Sergio Víctor. Fleni. Servicio de Cardiología; Argentina.
dc.description.fil Fil: Piña, Ileana L. Central Michigan University; Estados Unidos.
dc.relation.ispartofVOLUME 385
dc.relation.ispartofNUMBER 16
dc.relation.ispartofPAGINATION 1451-1461
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Boston
dc.relation.ispartofTITLE The New England journal of medicine
dc.relation.ispartofISSN 1533-4406
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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