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Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression

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dc.contributor.author Demarchi, Gianina
dc.contributor.author Perrone, Sofía
dc.contributor.author Esper Romero, Gaela
dc.contributor.author de Bonis, Cristian
dc.contributor.author Casasco, Juan Pablo
dc.contributor.author Sevlever, Gustavo Emilio
dc.contributor.author Berner, Silvia Inés
dc.contributor.author Cristina, Carolina
dc.date.accessioned 2022-08-26T12:28:01Z
dc.date.available 2022-08-26T12:28:01Z
dc.date.issued 2022-07
dc.identifier.citation Demarchi G, Perrone S, Esper Romero G, De Bonis C, Casasco JP, Sevlever G, Berner SI, Cristina C. Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression. Front Endocrinol (Lausanne). 2022 Jul 19;13:870172. doi: 10.3389/fendo.2022.870172. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/657
dc.identifier.uri https://doi.org/10.3389/fendo.2022.870172
dc.description.abstract Clinically silent corticotroph tumors are usually macroadenomas that comprise 20% of ACTH tumors. They frequently progress to aggressive tumors with high recurrence, invasiveness, and on rare occasions, they may become hormonally active causing Cushing's disease. Trustable biomarkers that can predict their aggressive course, as well as their response to traditional or new therapies, are paramount. Aberrant β-Catenin expression and localization have been proposed as responsible for several malignancies including pituitary tumors. Nevertheless, the role of β-Catenin in the aggressive transformation of silent corticotropinomas and their response to Temozolomide salvage treatment have not been explored yet. In this work, we present a case of a silent corticotroph tumor that invaded cavernous sinus and compressed optic chiasm and, after a first total resection and tumor remission it recurred six years later as an aggressive ACTH-secreting tumor. This lesion grew with carotid compromise and caused Cushing's signs. It required multiple medical treatments including Cabergoline, Ketoconazole, TMZ, and radiotherapy. Besides, other two surgeries were needed until it could be controlled. Interestingly, we found α-SMA vascular area reduction and differential β-Catenin cell localization in the more aggressive tumor stages characterized by high Ki-67 indexes and p53 expression. Our results may indicate a role of angiogenesis and β-Catenin trigged events in the pituitary tumor progression, which could in turn affect the response to TMZ and/or conventional treatments. These molecular findings in this unusual case could be useful for future management of aggressive pituitary tumors. es_ES
dc.language.iso eng es_ES
dc.publisher Frontiers Research Foundation es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Temozolomide es_ES
dc.subject Temozolomida es_ES
dc.subject Endocrine System Diseases es_ES
dc.subject Enfermedades del Sistema Endocrino es_ES
dc.title Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular. Laboratorio de Enfermedades Neurodegenerativas; Argentina.
dc.description.fil Fil: Demarchi, Gianin. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas; Argentina. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina.
dc.description.fil Fil: Perrone, Sofía. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas; Argentina. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina.
dc.description.fil Fil: Esper Romero, Gaela. Clínica Santa Isabel. Servicio de Neurocirugía; Argentina.
dc.description.fil Fil: De Bonis, Cristian. Clínica Santa Isabel. Servicio de Neurocirugía; Argentina.
dc.description.fil Fil: Casasco, Juan Pablo. Clínica Santa Isabel. Servicio de Neurocirugía; Argentina.
dc.description.fil Fil: Berner, Silvia Inés. Clínica Santa Isabel. Servicio de Neurocirugía; Argentina.
dc.description.fil Fil: Cristina, Carolina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas; Argentina. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina.
dc.relation.ispartofNUMBER 13
dc.relation.ispartofPAGINATION 870172
dc.relation.ispartofCOUNTRY Suiza
dc.relation.ispartofCITY Lausanne
dc.relation.ispartofTITLE Frontiers in endocrinology
dc.relation.ispartofISSN 1664-2392
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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