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Which biological pathways are responsible for the late appearance of brain metastases in renal cell carcinoma? Analysis of eight cases

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dc.contributor.author Minghinelli, Federico E.
dc.contributor.author Recalde, Rodolfo José
dc.contributor.author Prost, Diego Martín
dc.contributor.author Cutuli, Hernán Javier
dc.contributor.author Giovannini, Sebastián Juan María
dc.contributor.author Zaninovich, Roberto Steven
dc.date.accessioned 2022-11-24T14:38:59Z
dc.date.available 2022-11-24T14:38:59Z
dc.date.issued 2022-10-14
dc.identifier.citation Minghinelli FE, Recalde RJ, Prost DM, Cutuli HJ, Giovannini SJM, Zaninovich RS. Which biological pathways are responsible for the late appearance of brain metastases in renal cell carcinoma? Analysis of eight cases. Surg Neurol Int. 2022 Oct 14;13:466. doi: 10.25259/SNI_713_2022. es_ES
dc.identifier.uri https://doi.org/10.25259/sni_713_2022
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/722
dc.description.abstract Background: Renal cell carcinoma (RCC) represents 1% of all cancers and its brain metastases amount to 8.1% of all metastatic tumors. Late brain metastases are defined as tumors that appear 10 years after diagnosis of the primary lesion. The objective of this work is to discuss which biological pathways are responsible for the late appearance of these metastases analyzing eight cases. Case description: We report here eight cases of late brain metastases of RCC treated between 2018 and 2021. Patients consulted for different clinical complaints. Brain magnetic resonance imaging and computed tomography scan were performed on all patients. They were treated by complete surgical resection plus radiosurgery or by radiosurgery alone. The histology of most metastases showed clear cell RCC. Conclusion: In the presence of a patient with an intracranial tumor and a history of RCC with more than 10 years of evolution, the presence of late metastasis should always be considered. There are many theories described in the literature that try to explain the late appearance of brain metastases from RCC (low mitotic index, impaired immune system, cross talk, self-seeding, and among others). es_ES
dc.language.iso eng es_ES
dc.publisher Scientific Scholar LLC es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Carcinoma, Renal Cell es_ES
dc.subject Carcinoma de Células Renales es_ES
dc.subject Brain Neoplasms es_ES
dc.subject Neoplasias Encefálicas es_ES
dc.title Which biological pathways are responsible for the late appearance of brain metastases in renal cell carcinoma? Analysis of eight cases es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:ar-repo/semantics/artículo es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Giovannini, Sebastián Juan María. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Minghinelli, Federico E. Hospital de Clínicas José de San Martín. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Recalde, Rodolfo José. Hospital de Clínicas José de San Martín. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Prost, Diego Martín. Hospital de Clínicas José de San Martín. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Cutuli, Hernán Javier. Universidad de Buenos Aires. Instituto de Oncología Ángel H. Roffo; Argentina.
dc.description.fil Fil: Zaninovich, Roberto Steven. Hospital de Clínicas José de San Martín. Departamento de Neurocirugía; Argentina.
dc.relation.ispartofVOLUME 13
dc.relation.ispartofPAGINATION 466
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Pittsford
dc.relation.ispartofTITLE Surgical neurology international
dc.relation.ispartofISSN 2152-7806
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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