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Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study

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dc.contributor.author Yasuda, Marcos Ezequiel
dc.contributor.author Renedo, Daniela
dc.contributor.author Sosa, Soledad
dc.contributor.author Danilowicz, Karina
dc.contributor.author Recalde, Rodolfo José
dc.contributor.author Zaninovich, Roberto Steven
dc.contributor.author Gonzalez Abbati, Santiago
dc.contributor.author Cervio, Andrés Eduardo
dc.contributor.author Giovannini, Sebastián Juan María
dc.contributor.author Villalonga, Juan Francisco
dc.contributor.author Ulloque Caamaño, Liezel
dc.contributor.author Reddy, Kesava
dc.contributor.author Socolovsky, Mariano
dc.contributor.author Campero, Álvaro
dc.date.accessioned 2023-12-13T16:12:09Z
dc.date.available 2023-12-13T16:12:09Z
dc.date.issued 2023-04-07
dc.identifier.citation Yasuda ME, Renedo D, Sosa S, Danilowicz K, Recalde R, Zaninovich R, Abbati SG, Cervio A, Giovannini S, Villalonga J, Ulloque-Caamaño L, Reddy K, Socolovsky M, Campero A. Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study. World Neurosurg. 2023 Jul;175:e636-e643. doi: 10.1016/j.wneu.2023.03.150 es_ES
dc.identifier.uri https://doi.org/10.1016/j.wneu.2023.03.150
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/909
dc.description.abstract Objective: To analyze and find risk factors associated with developing transient diabetes insipidus (DI) using a multicenter case series after trans-sphenoidal surgery. Methods: Medical records of patients who underwent trans-sphenoidal surgery for pituitary adenoma resection between 2010 and 2021 at 3 different neurosurgical centers by 4 experienced neurosurgeons were retrospectively analyzed. The patients were divided into 2 groups (DI group or control group). Logistic regression analysis was conducted to identify risk factors associated with postoperative DI. Univariate logistic regression was performed to identify variables of interest. Covariates with a P value <0.05 were incorporated into multivariate logistic regression models to identify independently associated risk factors for DI. All statistical tests were conducted using RStudio. Results: A total of 344 patients were included; 68% were women, the mean age was 46.5 years, and nonfunctioning adenomas were the most frequent (171, 49.7%). The mean tumor size was 20.3 mm. Covariates associated with postoperative DI were age, female gender, and gross total resection. The multivariable model showed that age (odds ratio [OR] 0.97, CI 0.95-0.99, P = 0.017) and female gender (OR 2.92, CI 1.50-6.03, P = 0.002) remained significant predictors of DI development. Gross total resection was no longer a significant predictor of DI in the multivariable model (OR 1.86, CI 0.99-3.71, P = 0.063), suggesting that this variable may be confounded by other factors. Conclusions: The independent risk factors for the development of transient DI were female and young patients. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.subject Adenoma es_ES
dc.subject Diabetes Insipidus es_ES
dc.subject Diabetes Insípida es_ES
dc.subject Diabetes Mellitus es_ES
dc.subject Pituitary Neoplasms es_ES
dc.subject Neoplasias Hipofisarias es_ES
dc.subject Postoperative Complications es_ES
dc.subject Complicaciones Posoperatorias es_ES
dc.title Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Cervio, Andrés Eduardo. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Giovannini, Sebastián Juan María. Fleni. Departamento de Neurocirugía; Argentina.
dc.relation.ispartofVOLUME 175
dc.relation.ispartofPAGINATION e636-e643
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE World neurosurgery
dc.relation.ispartofISSN 1878-8769
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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