Neurología: Recent submissions

  • Brain metabolic subtypes in Long Covid individuals from a Brazilian cohort 
    Viana Jotz, Arthur; De Bastiani, Marco; Santos Machado, Luiza; Hugentobler Schlickmann, Thomas; Silveira, Maiele Dornelles; Senger, Joana Emilia; Vendramini Borelli, Wyllians; Ferrari‐Souza, João Pedro; Povala, Guilherme; Bornes da Silva, Ana Paula; Uglione da Ros, João Pedro; Bastos de Mello, Guilherme; Fakhri Kadan, Matheus; Radaelli, Graciane; de Paula de Paula Faria, Daniele; Martins Coutinho, Artur; Lourenco, Mychael V.; Hernández, Micaela Anahí; Calandri, Ismael Luis; Pascoal, Tharick A.; Matushita, Cristina Sebastião; Benardi Soder, Ricardo; Schumacher‐Schuh, Artur Francisco; Souza, Diogo O.; Costa da Costa, Jaderson; Guerini de Souza, Débora; Zimmer, Eduardo R. (John Wiley & Sons, 2024)
    Background: The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is one of the biggest health concerns of the century. Long COVID is one of the major sequelae from the infection and include persistent neurological ...
  • Long-term follow-up of patients with a first clinical demyelinating event (clinically isolated syndrome) who received cladribine tablets in CLASSIC-MS: Findings for the ORACLE-MS cohort 
    Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; di Cantogno, Elisabetta Verdun (SAGE, 2024-12-17)
    Background: CLASSIC-MS explored long-term outcomes of patients treated with cladribine tablets. Objective: Assess long-term efficacy in patients previously enrolled in ORACLE-MS, a Phase III parent trial. Methods: ...
  • Frailty and Implications for Multiple Sclerosis Management 
    Correale, Jorge (American Medical Association, 2025-03-03)
    This Viewpoint discusses the unique needs of patients with multiple sclerosis and frailty and describes the gaps that should be addressed in frailty measurement and clinical management.
  • Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations 
    Farina, Francesca R.; Bridgeman, Katie; Gregory, Sarah; Crivelli, Lucía; Foote, Isabelle F.; Jutila, Otto-Emil I.; Kucikova, Ludmila; Mariano, Luciano I.; Nguyen, Kim-Huong; Thayanandan, Tony; Akindejoye, Funmi; Butler, Joe; Calandri, Ismael Luis; Čepukaitytė, Giedrė; Chiesa, Scott T.; Dawson, Walter D.; Deckers, Kay; De la Cruz-Góngora, Vanessa; Dounavi, Maria-Eleni; Govia, Ishtar (Elsevier, 2024-12-20)
    fforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a ...
  • Emerging immune tolerance therapies for neuromyelitis optica spectrum disorder 
    Carnero Contentti, Edgar; Correale, Jorge (Taylor & Francis, 2025-02-23)
    Resumen no disponible
  • Cost evaluation of acute ischemic stroke in Latin America: a multicentric study 
    Dittrich, Luiza Borba; da Silva Etges, Ana Paula Beck; Siqueira de Souza, Joana; Zago Marcolino, Miriam Allein; Rocha, Eva; Amaya, Pablo; Barboza, Miguel A.; Saavedra, Andrés Gaye; Pérez Hornos, Gonzalo; Abanto, Carlos; Castillo-Soto, Ana Lucía; Llanos-Leyton, Natalia; Pujol Lereis, Virginia Andrea; Rodriguez Pérez, María Soledad; Alet, Matías Javier; Navia, Victor; Lopez, Solange; Arauz, Antonio; Serrano, Fabiola; Chwal, Bruna; Carbonera, Leonardo Augusto; Gomes Nogueira, Raul; Saposnik, Gustavo; Polanczyk, Carisi Anne; Ouriques Martins, Sheila Cristina; de Souza, Ana Cláudia (Elsevier, 2024-12-06)
    Background: Current literature highlights a gap in precise stroke cost data for Latin America. This study measures the real costs associated with acute ischemic stroke care in Latin America using Time-Driven Activity-Based ...
  • Risk factors and baseline cognition. Preliminary results from the LatAm-FINGERS cohort 
    Corvalán, Nicolás; Keller, Greta; Surace, Ezequiel Ignacio; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Monica; Allegri, Ricardo Francisco; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Sevlever, Gustavo Emilio; Crivelli, Lucía; LatAm-FINGERS Consortium (Wiley, 2024)
    Background LatAm-FINGERS - the first non-pharmacological multicenter randomized clinical trial in Latin America - is a valuable opportunity to study lifestyle in a heterogeneous and multiethnic population exposed to a ...
  • Live-attenuated vaccines for multiple sclerosis patients living in regions with endemic infections: A complex decision 
    Correale, Jorge; Marrodán, Mariano (Sage, 2024-12-18)
    Live-attenuated vaccines provide robust immunity against diseases like tuberculosis, measles, mumps, rubella, polio, yellow fever, dengue, typhoid fever, and varicella, with just one or a few doses. However, concerns arise ...
  • Chapter 10 - Autoimmune Astrocytopathy 
    Correale, Jorge (Springer Nature, 2024)
    Astrocytes constitute the most abundant type of glial cells in the central nervous system (CNS) and display significant heterogeneity. Astrocytes actively engage in various metabolic processes and are active contributors ...
  • Case report: A 50 year-old Down syndrome man exhibiting noAlzheimer’s disease biomarker profile nor cognitiveimpairment. Experience from the Argentine Initiative for theStudy of Down syndrome and Alzheimer’s 
    Clas, Giulia Solange; Pertierr, Lucía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda; Magrath Guimet, Nahuel; Allegri, Ricardo Francisco; Marazita, Mariela Claudia; Romorini, Leonardo; Surace, Ezequiel Ignacio (Wiley, 2024)
    Background: Down Syndrome (DS) is the most common genetic form of intellectualdisability. In recent years, there has been a significant increase in the life expectancyof individuals with DS, currently reaching the age of ...
  • Additional Cladribine tablets treatment courses in multiple sclerosis patients. A retrospective observational study in Latin American countries 
    Silva, Berenice Anabel; Ysrraelit, María Célica; Zanga, Gisela; Segamarchi, María Constanza; Cragnolini, Carolina; Galleguillos, Lorna; Halfon, Mario Javier; Miguez, Jimena; Parada Marcilla, Marcela; Pereyra, Adriana; Silva, Emanuel; Vrech, Carlos; D'Eramo, Mariana; Negrotto, Laura (Elsevier, 2025-01-14)
    The use of additional cladribine tablets treatment courses is becoming an option in patients with multiple sclerosis (MS) showing disease activity after treatment initiation. Despite the availability over the past year of ...
  • Classification and Genotype-Phenotype Relationships of GBA1 Variants: MDSGene Systematic Review 
    Rossi, Malco Damián; Schaake, Susen; Usnich, Tatiana; Boehm, Josephine; Steffen, Nina; Schell, Nathalie; Krüger, Clara; Gül-Demirkale, Tuğçe; Bahr, Natascha; Kleinz, Teresa; Madoev, Harutyun; Laabs, Björn-Hergen; Gan-Or, Ziv; Alcalay, Roy N.; Lohmann, Katja; Klein, Christine (Wiley, 2025-02-10)
    Depending on zygosity and the specific change, different variants in the GBA1 gene can cause Parkinson's disease (PD, PARK-GBA1) with reduced penetrance, act as genetic risk factors for PD or parkinsonism, and/or lead to ...
  • Performance of treatment response scoring systems among patients with multiple sclerosis treated with high-efficacy therapies 
    Marrodán, Mariano; Sao Avilés, Augusto; Río, Jordi; Cobo-Calvo, Álvaro; Fernández, Victoria; Pappolla, Agustin; Castilló, Joaquín; Vidal-Jordana, Ángela; Arrambide, Georgina; Tur, Carmen; Rodríguez-Acevedo, Breogán; Zabalza, Ana; Mongay-Ochoa, Neus; Vilaseca, Andreu; Rodriguez, Marta; Galán, Ingrid; Comabella, Manuel; Sastre-Garriga, Jaume; Tintoré, Mar; Auger, Cristina (Sage, 2025-02-10)
    Background: Predicting treatment response and disease progression in multiple sclerosis (MS) is challenging. Treatment Response Scoring Systems (TRSS) are potentially useful, but their utility in patients receiving ...
  • The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset. 
    Liu, Haiyan; Marsh, Thomas W.; Shi, Xinyu; Renton, Alan E.; Bowling, Kevin M.; Ziegemeier, Ellen; Wang, Guoqiao; Cao, Yuchen; Aristel, Alisha; Li, Jessie; Dickson, Alexa; Perrin, Richard J.; Goate, Alison M.; Fernández, Victoria; Day, Gregory S.; Doering, Michelle; Daniels, Alisha; Supnet-Bell, Charlene; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Oxford University Press, 2025-02-04)
    We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). A total of 550 variants in the APP, PSEN1, and PSEN2 genes were identified, of which 279 were ...
  • Exosomal mRNA Signatures as Predictive Biomarkers for Risk and Age of Onset in Alzheimer's Disease 
    Bolívar, Daniel A.; Mosquera Heredia, María I.; Vidal, Oscar M.; Barceló Martínez, Ernesto; Allegri, Ricardo Francisco; Morales, Luis C.; Silvera Redondo, Carlos; Arcos Burgos, Mauricio; Garavito Galofre, Pilar; Vélez, Jorge I. (MDPI, 2024-11-15)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. While the precise causes of AD remain unclear, emerging evidence suggests that messenger RNA (mRNA) ...
  • Eculizumab or ravulizumab treatment effect in people with neuromyelitis optica spectrum disorder: a plain language summary of three studies 
    Damasceno, Alfredo; Marrodán, Mariano (Future Medicine, 2025-02-12)
    What is this summary about?: Neuromyelitis optica spectrum disorder (NMOSD for short) is a rare autoimmune health condition, meaning that the body's natural defense system (the immune system) attacks the body's own tissues. ...
  • Adult polyglucosan body disease: ultrarare but commonly misdiagnosed 
    Caiza-Zambrano, Francisco; Aldecoa, Mayra; Rugilo, Carlos; Taratuto, Ana Lía; Marchesoni, Cintia; León-Cejas, Luciana; Reisin, Ricardo; Bonardo, Pablo (BMJ Pub. Group, 2025-02-16)
    Adult polyglucosan body disease is a rare genetic condition caused by biallelic pathogenic variants in GBE-1 gene. Affected patients typically have urinary dysfunction, progressive gait disturbance and cognitive impairment. ...
  • Validation of an Artificial Intelligence-Powered Virtual Assistant for Emergency Triage in Neurology 
    Alessandro, Lucas; Crema, Santiago; Castiglione, Juan Ignacio; Dossi, Daiana Elizabeth; Eberbach, Federico; Kohler, Alejandro Alfredo; Laffue, Alfredo Hernan; Marone, Abril; Nagel, Vanesa; Pastor Rueda, José Manuel; Varela, Francisco José; Fernández Slezak, Diego; Rodríguez Murúa, Sofía; Debasa, Carlos; Pensa, Claudio; Farez, Mauricio Franco (Lippincott Williams & Wilkins, 2025-02-06)
    Objectives: Neurological emergencies pose significant challenges in medical care in resource-limited countries. Artificial intelligence (AI), particularly health chatbots, offers a promising solution. Rigorous validation ...
  • A Leaving Note from the Editors of Movement Disorders Clinical Practice 
    Bhatia, Kailash P.; Merello, Marcelo (Wiley, 2024-11-13)
  • Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review 
    Crivelli, Lucía; Winkler, Andrea Sylvia; Keller, Greta; Beretta, Simone; Calandri, Ismael Luis; De Groote, Wouter; Fornari, Arianna; Frontera, Jennifer; Kivipelto, Miia; Lopez-Rocha, Ana Sabsil; Mangialasche, Francesca; Munblit, Daniel; Palmer, Katie; Guekht, Alla; Allegri, Ricardo Francisco (Elsevier, 2025-03)
    Background This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with ...

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