Background: Corticobasal syndrome (CBS) is a rare, clinically heterogeneous form of atypical Parkinsonism. Hyperkinetic movements, aside from myoclonus and dystonia, have rarely been reported in CBS.
Cases: We present ...
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts
and leukoencephalopathy (CADASIL), the most common hereditary small vessel
disease, leads to early-onset stroke and vascular cognitive ...
Background: Levodopa-induced dyskinesias (LIDs) are an important burden for patients with Parkinson's disease (PD), yet their mechanisms remain incompletely understood.
Objective: The objective of this study was to ...
Vitturi, Bruno Kusznir; Cellerino, Maria; Boccia, Daniele; Leray, Emmanuelle; Correale, Jorge; Dobson, Ruth; van der Mei, Ingrid; Fujihara, Kazuo; Inglese, Matilde(Wiley, 2025-10-28)
Background: We aimed to provide updated evidence from the current literature regarding pediatric environmental factors associated with the risk of developing multiple sclerosis (MS).
Methods: Articles were searched in ...
Objective:
We tested the SmartRehab efficacy, usability, and feasibility for stroke rehabilitation across seven countries.
Background:
Stroke is a major cause of disability worldwide. Timely and personalized rehabilitation ...
Russo, María Julieta; Sampayo, María de la Paz; Arias, Paula; García, Vanina; Gambero, Yanina; Maiarú, Mariano; Deschle, Florencia; Pavón, Hernán(MDPI, 2025-10-07)
Background: The Coma Recovery Scale-Revised (CRS-R) is the gold standard for diagnosing chronic disorders of consciousness (DoC); however, its clinical utility is limited by lengthy administration and the need for specialized ...
Oomens, Julie E.; Vos, Stephanie Jb; Maserejian, Nancy N.; Boada, Mercè; Didic, Mira; Engelborghs, Sebastiaan; Fladby, Tormod; van der Flier, Wiesje M.; Frisoni, Giovanni B.; Fröhlich, Lutz; Gill, Kiran Dip; Grimmer, Timo; Hort, Jakub; Allegri, Ricardo Francisco; Alzheimer's Disease Neuroimaging Initiative (ADNI); A4 Study group; Dominantly Inherited Alzheimer Network (DIAN); European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI); Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE); Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group(Sage, 2025-11-13)
BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking ...
Pontes-Neto, Octávio M.; Noble-Lugo, Alejandra; Montenegro Arenas, Ana Cristina; de Campos Guerra, Joao Carlos; Ceresetto, Jose Manuel; Rosales, Julieta Soledad; Colunga-Lozano, Luis Enrique; Meillon-Garcia, Luis Antonio; Vargas Tellez, Luis Eduardo; Dos Reis Rodrigues, Roseny; Gibler, W. Brian; Kreitzer, Natalie P.(Elsevier, 2025-05-05)
Background: Bleeding is the most important complication associated with anticoagulants. Patients experiencing bleeding while on an anticoagulation require proper risk stratification, which involves careful assessment of ...
Piedrabuena, María Agustina; Correale, Jorge; Silva, Berenice; Fiol, Marcela; Marrodán, Mariano; Zárate, María Agustina; Heriz, Alejandra; Ayerbe, Jeremías; Míguez, Jimena; Pita, Cecilia; Lázaro, Luciana; Casas, Magdalena; López, Pablo Adrián; Tkachuk, Verónica; Balbuena, María Eugenia; Nadur, Débora; Liwacki, Susana; Luetic, Geraldine; Burgos, Marcos; Ysrraelit, María Célica(Elsevier, 2025-11-15)
Background: Despite an aging multiple sclerosis (MS) population, clinical outcomes and long-termeffects of disease-modifying therapies in patients aged ≥50 years remain under-studied.
Objective: To compare the efficacy ...
Martínez de Sucre, M. Nahuel; Bianchi, Gianfranco; Wilken, Miguel; Cruz Molina, Cecilia; Noel, Gabriel; Andrés, Daniela(Springer, 2025-10-16)
Parkinson’s disease (PD) is characterized by progressive motor and sensorimotor deficits, including impairments in proprioception and grip force control. Despite their clinical relevance, these alterations are rarely ...
Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge(MDPI, 2025-09-30)
Therapeutic plasma exchange (TPE) is increasingly recognized as a critical escalation therapy for managing acute multiple sclerosis (MS) relapses refractory to high-dose corticosteroids. Neuropathological and clinical ...
Background and objectives: Anti-N-Methyl-d-aspartate receptor encephalitis (NMDARE) is the most prevalent autoimmune encephalitis, primarily affecting young females. Its clinical heterogeneity, particularly in underrepresented ...
Marcora, María S.; Katz, Maximiliano J.; Galo, Azul; Bochicchio, Pablo; Bongiovanni, Vinicius; Bodín, Diego H.; Pagani, Mario R.; Correale, Jorge; Pasquini, María J.(Wiley, 2025-11-10)
Iron deficiency (ID) is the most common micronutrient deficiency globally. ID in pre- and post-natal periods has been associated with impaired neurological development and altered behavior, which may persist despite iron ...
Objectives: For the past five years, COVID-19 has not only been a priority for health planning but also a hotspot for clinical research. Yet, the weight of the worldwide COVID-19 pandemic arises from the critical phase ...
Introduction: Timely diagnosis of schizophrenia is essential to ensure prompt treatment initiation and adherence. Structural magnetic resonance imaging (sMRI), when combined with artificial intelligence (AI), offers a ...
BackgroundPathogenic variants in PSEN1, PSEN2, or AβPP cause early-onset Alzheimer's disease (EOAD). Several novel variants remain of uncertain significance (VUS) due to limited evidence. The PSEN1 p.R358P variant has not ...
Bottino, Marina; Boyer, Monica; Steenari, Maija R.; Barrick, Rebekah; Abdenur, Jose E.(Elsevier, 2025-10-10)
Pyridoxine-Dependent Epilepsy (PDE) is an autosomal recessive disorder caused by biallelic variants in ALDH7A1. The most common presentation is intractable seizures in the neonatal/early infantile period, which respond to ...
Berrios, Waleska; Deschle, Florencia; Caporale, Sofía; Di Fonzo, Guido; Moreno, María Cecilia; Saglio, María Laura; Cervino, Cecilia Verónica; Povedano, Guillermo(Polemos, 2025-10-10)
Introducción: La queja cognitiva subjetiva (QCS) se refiere a la percepción de alteraciones cognitivas en individuos con rendimiento normal en pruebas neuropsicológicas. Las QCS están asociadas con un mayor riesgo de ...
Background: MDS-UPDRS Severity Levels (SLs), derived from clinician- and patient-rated scales, remain underused to evaluate response to subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson's disease ...
Adell, Matias F.; Balda, Javier; Casas, Facundo; D’Giano, Carlos; Quintero-Rincón, Antonio(Instituto de Investigación en Informática, 2025-06)
Epilepsy is a common neurological disorder diagnosed and monitored through EEG recordings. Accurate spike-and-wave (SW) pattern classification is crucial for distinguishing this epileptic seizure disorder from normal brain ...