Introduction: Sleep and circadian rest-activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR ...
Objective: To develop regression-based normative data for a set of widely used neuropsychological tests and to provide a freely accessible normative data calculator for use in Buenos Aires, Argentina. Methods: Participants ...
Background: Social inequalities are key health determinants shaping Alzheimer’s disease (AD) progression. In dominantly inherited Alzheimer’s disease (DIAD), where genetic causes are established, the influence of socioeconomic ...
Background: LatAm FINGERS is a feasibility trial aimed at preventing cognitive decline in individuals at risk through lifestyle changes in Latin America, with its objectives aligned with the RE‐AIM (Reach, Effectiveness, ...
Gilbert, Afra; Gatto, Emilia M.; Chocobar, Nicolas; Seguí, Josefina; Crotti, Beatriz; Cubas Guillen, Jonathan Fernando; Merchan del Hierro, Xavier; Bacigalupe, Lucia; Persi, Gabriel; Melcon, Carlos Mario; O'Neill, Santiago; Múnera Martínez, Claudia Patricia; Sierra Sanjurjo, Natalia; Rojas, Galeno J.; Tribbia,Teresita Liliana; Taravini, Irene(Wiley, 2025-12-23)
Background: Yerba mate (YM), an infusion made from Ilex paraguariensis, is widely consumed in Argentina and other South American countries. Experimental studies have shown that YM enhances antioxidant defenses, increases ...
Background: Latin America (LA) faces heightened vulnerability to modifiable dementia risk factors. Early identification of at‐risk individuals is crucial for implementing effective preventive strategies. The Free and Cued ...
Background: The Cognitive Function Index (CFI) was developed to identify individuals with Subjective Cognitive Decline (SCD), which is defined by the self‐perception of cognitive impairment, not detected in neuropsychological ...
Pucinelli de Souza Queiroz, Andréia; Pozzolo Pedro, Maria Olivia; Waisman Campos, Marcela; Torales, Julio; Ventriglio, Antonio; Castaldelli-Maia, João Mauricio(MDPI, 2025-07-15)
Cannabis is the most widely consumed illicit substance worldwide, with rising use particularly among adolescents and young adults. Accumulating evidence indicates that chronic cannabis use may negatively impact several ...
Introduction: White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear.
Methods: Longitudinal MRI study, including ...
Olavarría, Loreto; Dechent, Claudia; Parra Rodriguez, Mario Alfredo; Crivelli, Lucía; Custodio Capuñay, Nilton Santos; Dozzi Brucki, Sonia María; Okada de Oliveira, Maira; Robert, Phillip; Quiroz, Yakeel T.; Antivilo Bruna, Andrés; Arboleda Ramírez, Alejandra; Lillo, Patricia; Carello, María Agostina; Torralba, Teresa; Ramos, Teresita; Duran Aniotz, Claudia; Allegri, Ricardo Francisco; Slachevsky, Andrea(Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento, 2026-03-06)
La pandemia de COVID-19 aceleró el uso de la teleneuropsicología (TeleNP) para ofrecer servicios neuropsicológicos remotos en entornos con acceso limitado a clínicas.
Objetivo: Examinar las prácticas de TeleNP en América ...
Groot, Colin; Calandri, Ismael Luis; Bader, Ilse; Bocancea, Diana I.; de Bruin, Hannah; Carrigan, Maria; Kamps, Suzie; de Koning, Lotte A.; Mastenbroek, Sophie E.; Rikken, Roos M.; van Tol, Bastiaan G. J.; Vermeiren, Marie R.; Wesseling, Alex; Xia, Ye; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Barkhof, Frederik; Jonkman, Laura E.; van der Lee, Sven J.; de Boer, Casper(Wiley, 2026-01-07)
Background
Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, ...
McCullough, Austin; Chen, Charles D.; Gordon, Brian A.; Joseph-Mathurin, Nelly; Jack Jr, Clifford R; Koeppe, Robert; Hornbeck, Russ; Koudelis, Deborah; McKay, Nicole S.; Hobbs, Diana A.; Flores, Shaney; Keefe, Sarah J.; Aggarwal, Neelum T.; Allegri, Ricardo Francisco; Berman, Sarah B.; Bird, Thomas; Black, Sandra E.; Brooks, William S.; Chhatwal, Jasmeer P.; Day, Gregory S.; DIAN‐TU Study Team(Wiley, 2025-07)
Introduction: Monoclonal anti-amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose ...
Llibre Guerra, Jorge J.; Lu, Ruijin; Clarens, María Florencia; Liu, Ian; Renton, Alan E.; Ryan, Natalie S.; Goate, Alison M.; Aguillón, David; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Vigo, Gabriela; Cruchaga, Carlos; Day, Gregory S.; Farlow, Martin R.; Fox, Nick C.; Gordon, Brian A.; Hassenstab, Jason(Lippincott Williams & Wilkins, 2026-04-28)
Background and objectives: Cognitive reserve has been shown to modulate the onset and progression of Alzheimer disease (AD) symptoms. Although its role in sporadic AD is well-studied, how cognitive reserve influences the ...
Groot, Colin; Calandri, Ismael Luis; Bader, Ilse; Bocancea, Diana I.; de Bruin, Hannah; Carrigan, Maria; Collij, Lyduine E.; Duits, Flora H.; Kamps, Suzie; de Koning, Lotte A.; Lemstra, Afina W.; Mastenbroek, Sophie E.; Rikken, Roos M.; van Tol, Bastiaan G. J.; Vermeiren, Marie R.; Wesseling, Alex; Xia, Ye; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Barkhof, Frederik(Lippincott Williams & Wilkins, 2026-05-12)
Background and objectives: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, ...
Barceló, Ernesto; Romero, Duban; Allegri, Ricardo Francisco; Meza, Eliana; Mosquera-Heredia, María I.; Vidal, Oscar M.; Silvera-Redondo, Carlos; Arcos-Burgos, Mauricio; Garavito-Galofre, Pilar; Vélez, Jorge I.(MDPI AG, 2025-11-28)
Background/Objectives: Alzheimer's disease (AD) accounts for ~70% of global dementia cases, with projections estimating 139 million affected individuals by 2050. This increasing burden highlights the urgent need for ...
Espeland, Mark A.; Olson, Kay Loni; Tangney, Christy C.; Gitelman, Darren R.; Cleveland, Maryjo L.; Thro, Amber A.; Demesie, Yitbarek N.; Snyder, Heather M.; Whitmer, Rachel A.; Desai, Pankaja; Alam, Rifat; Crivelli, Lucía; Holland, Thomas M.; Preissle, Olivia; Raman, Rema; York, Michele K.; Baker, Laura; U.S. POINTER Study Group(Gerontological Society of America by Oxford University Press, 2026-05)
Background: Multidomain lifestyle interventions hold promise as approaches to slow aging. Deficit accumulation frailty indices (FIs) are increasingly used to capture aging processes. Frailty is highly associated with ...
Donaghy, Paul C.; Greenfinch, Gemma; Petrides, George; Kane, Joseph; Verberne, Hein J.; Taylor, John-Paul; O'Brien, John T.; Thomas, Alan J.; DLB Indicative Imaging Biomarker Study Group(Wiley on behalf of the Alzheimer's Association, 2026-03-04)
Introduction: The aim of this Delphi process was to develop consensus guidelines to support the effective use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy in the diagnosis of ...
Alzheimer's disease (AD) pathology begins years before symptoms emerge, making early detection essential. Eye tracking offers a rapid, non-invasive means of identifying early cognitive decline through oculomotor disturbances. ...
Most people with dementia live in low- and middle-income countries (LMICs), but scientific knowledge about dementia is dominated by Global North perspectives. This interdisciplinary article combines expertise from Latin ...
Understanding the biological and genetic landscape of neurodegenerative diseases in diverse populations deepens our insight into complex pathophysiological mechanisms. Our laboratory, established 14 years ago in Buenos ...