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Listar Enfermedades Desmielinizantes.artículos por autor "Pasquini, Juana María"

Listar Enfermedades Desmielinizantes.artículos por autor "Pasquini, Juana María"

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  • 2-Chlorodeoxyadenosine (Cladribine) preferentially inhibits the biological activity of microglial cells 
    Aybar, Florencia; Pérez, María Julia; Marcora, María Silvina; Samman, María Eugenia; Marrodán, Mariano; Pasquini, Juana María; Correale, Jorge (Elsevier Science, 2022-01-29)
    Cladribine (2CdA) is a synthetic chlorinated purine nucleoside analogue which acts as a pro-drug requiring intracellular phosphorylation to be activated. It is biologically active in selected cell types, which results in ...
  • Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model 
    Wies Mancini, Victoria Sofía Berenice; Di Pietro, Anabella A.; de Olmos, Soledad; Silva Pinto, Pablo; Vence, Marianela; Marder, Mariel; Igaz, Lionel M.; Marcora, María Silvina; Pasquini, Juana María; Correale, Jorge; Pasquini, Laura Andrea (Oxford, 2022-03)
    Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting from a combination of inflammatory mediators, demyelination, and loss of trophic support. During progressive ...
  • Combination therapy of apo-transferrin and thyroid hormones enhances remyelination 
    Rosato-Siri, María Victoria; Marziali, Leandro Nazareno; Mattera, Vanesa S.; Correale, Jorge; Pasquini, Juana María (Wiley-Liss, 2020-08-20)
    The current study presents two different approaches with a view to elucidating the interaction between thyroid hormones (TH) and apo-transferrin (aTf) and their role in myelination and remyelination. First, in vitro assays ...
  • Extracellular vesicles containing the transferrin receptor as nanocarriers of apotransferrin 
    Mattera, Vanesa S.; Pereyra Gerber, Pehuén; Glisoni, Romina; Ostrowski, Matias; Verstraeten, Sandra V.; Pasquini, Juana María; Correale, Jorge (Raven Press, 2020-11)
    Previous work by our group has shown the pro-differentiating effects of apotransferrin (aTf) on oligodendroglial cells in vivo and in vitro. Further studies showed the remyelinating effect of aTf in animal demyelination ...
  • Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination 
    Cheli, Veronica T.; Correale, Jorge; Paez, Pablo M.; Pasquini, Juana María (Sage, 2020-01)
    Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron excess may result in harmful effects in the CNS. Oligodendrocytes and astrocytes are crucial ...
  • Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes 
    Wies Mancini, Victoria Sofía Berenice; Mattera, Vanesa S.; Pasquini, Juana María; Pasquini, Laura Andrea; Correale, Jorge (Wiley on behalf of the International Society for Neurochemistry, 2023-12-06)
    Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively ...
  • Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination 
    Wies Mancini, Victoria Sofía Berenice; Pasquini, Juana María; Correale, Jorge; Pasquini, Laura Andrea (Wiley, 2018-11-19)
    Multiple sclerosis (MS) is one of the most common causes of progressive disability affecting young people with very few therapeutic options available for its progressive forms. Its pathophysiology involves demyelination ...
  • Ontogenetic Oligodendrocyte Maturation Through Gestational Iron Deprivation: The Road Not Taken 
    Guitart, María Eugenia; Vence, Marianela; Correale, Jorge; Pasquini, Juana María; Rosato-Siri, María Victoria (Wiley, 2019-06-04)
    Developmental iron deficiency (dID) models facilitate the study of specific oligodendrocyte (OL) requirements for their progression to a mature state and subsequent contribution to myelination. In the current work, we used ...
  • Remyelinating effect driven by transferrin-loaded extracellular vesicles 
    Mattera, Vanesa S.; Occhiuzzi, Federico; Correale, Jorge; Pasquini, Juana María (Wiley, 2023-10-20)
    Extracellular vesicles (EVs) are involved in diverse cellular functions, playing a significant role in cell-to-cell communication in both physiological conditions and pathological scenarios. Therefore, EVs represent a ...
  • Transferrin Enhances Microglial Phagocytic Capacity 
    Carden, Tomás R.; Correale, Jorge; Pasquini, Juana María; Pérez, María Julia (Humana Press, 2019-02-13)
    Transferrin (Tf) is a glycoprotein playing a critical role in iron homeostasis and transport and distribution throughout the body and within tissues and cells. This molecule has been shown to accelerate the process of ...

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