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Accumulative risk of clinical event in high-risk radiologically isolated syndrome in Argentina: data from the nationwide registry RelevarEM

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dc.contributor.author Rojas, Juan Ignacio
dc.contributor.author Pappolla, Agustín
dc.contributor.author Blaya, Patricio A.
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Luetic, Geraldine G.
dc.contributor.author Liwacki, Susana
dc.contributor.author Barboza, Andrés G.
dc.contributor.author Burgos, Marcos
dc.contributor.author Cohen, Leila
dc.contributor.author Mainella, Carolina
dc.contributor.author Zanga, Gisela
dc.contributor.author Menichini, María Laura
dc.contributor.author Tavolini, Darío
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author López, Pablo Adrián
dc.contributor.author Lequizamon, Felisa
dc.contributor.author Knorre, Eduardo
dc.contributor.author Nofal, Pedro G.
dc.contributor.author Patrucco, Liliana
dc.date.accessioned 2021-09-23T16:26:53Z
dc.date.available 2021-09-23T16:26:53Z
dc.date.issued 2021-09-07
dc.identifier.citation Rojas JI, Pappolla A, Blaya P, Marrodán M, Ysrraelit MC, Luetic GG, Liwacki S, Barboza A, Burgos M, Cohen L, Mainella C, Zanga G, Menichini ML, Tavolini D, Tkachuk V, López PA, Lequizamon F, Knorre E, Nofal PG, Patrucco L, Miguez J, Cristiano E, Fiol M, Correale J, Gaitán MI, Alonso R, Silva B, Garcea O, Carrá A, Fernandez Liguori N, Alonso Serena M, Carnero Contentti E. Accumulative risk of clinical event in high-risk radiologically isolated syndrome in Argentina: data from the nationwide registry RelevarEM. J Neurol. 2021 Sep 7. doi: 10.1007/s00415-021-10791-4 es_ES
dc.identifier.uri https://doi.org/10.1007/s00415-021-10791-4
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/589
dc.description.abstract Introduction: We aimed to analyze the accumulative risk of MRI and OB factors for evolution from RIS to MS in subjects included in the Argentinean MS registry (NCT03375177). Methods: RIS subjects were identified according to RIS diagnosis criteria. Subjects were longitudinally followed with clinical and MRI at intervals of 6 months. Time from RIS identification to the first clinical event was estimated using Kaplan-Meier. Multivariable Cox regression models were created to assess the independent predictive value of demographic characteristics, as well as clinical, OB and MRI data on time to the first clinical event. The single and increased risk factor of evolution of RIS was quantified. Results: A total of 88 RIS subjects, mean follow-up time 42 ± 4 months were included. 39 (44.3%) and 23 (26.1%) had a new MRI lesion or a clinical event, respectively, during the follow-up. OB (HR 5.9, 95% CI 1.29-10.1, p = 0.004), infratentorial lesions (HR 3.7, 95% CI 1.09-7.5) and spinal cord lesions (HR 5.3, 95% CI 1.4-8.2, p = 0.01) at RIS identification were independent predictors associated with a subsequent clinical event. The accumulative risk showed that when two of the three factors (OB, infratentorial or spinal cord lesions) were present the HR was 10.4, 95% CI 4.4-22, p < 0.001, and when three factors were present, it was HR 15.6, 95% CI 5.7-28, p < 0.001 for a relapse. Conclusion: The presence of three factors significantly increased the risk of clinical event; high-risk subjects should probably be managed by a different approach than those used for individuals without high-risk factors. es_ES
dc.language.iso eng es_ES
dc.publisher Springer es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Argentina es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Radiologically isolated syndrome es_ES
dc.title Accumulative risk of clinical event in high-risk radiologically isolated syndrome in Argentina: data from the nationwide registry RelevarEM es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Rojas, Juan Ignacio. Centro de Esclerosis Múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires, Buenos Aires; Argentina.
dc.description.fil Fil: Blaya, Patricio A. Neurocomp; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, Maria Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Luetic, Geraldine G. Instituto de Neurociencias de Rosario; Argentina.
dc.description.fil Fil: Liwacki, Susana. Clínica Universitaria Reina Fabiola; Argentina.
dc.description.fil Fil: Barboza, Andrés G. Hospital Central de Mendoza; Argentina.
dc.description.fil Fil: Burgos, Marcos. Hospital San Bernardo; Argentina.
dc.description.fil Fil: Cohen, Leila. Hospital Dr. J. M. Ramos Mejía; Argentina.
dc.description.fil Fil: Mainella, Carolina. Hospital Español de Rosario; Argentina.
dc.description.fil Fil: Zanga, Gisela. Unidad Asistencial César Milstein; Argentina.
dc.description.fil Fil: Menichini, María Laura. Sanatorio Británico; Argentina.
dc.description.fil Fil: Tavolini, Darío. Fundación INECO; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín; Argentina.
dc.description.fil Fil: López, Pablo Adrián. Hospital Aleman; Argentina.
dc.description.fil Fil: Lequizamon, Felisa. Hospital de Agudos Dr. Teodoro Álvarez; Argentina.
dc.description.fil Fil: Knorre, Eduardo. Hospital de Agudos Dr. Teodoro Álvarez; Argentina.
dc.description.fil Fil: Nofal, Pedro G. Sanatorio Güemes; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Hospital Italiano de Buenos Aires; Argentina.
dc.relation.ispartofCOUNTRY Alemania
dc.relation.ispartofCITY Berlín
dc.relation.ispartofTITLE Journal of neurology
dc.relation.ispartofISSN 1432-1459
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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