Repositorio Institucional FLENI: Envíos recientes

  • Awareness, attitudes, and barriers toward Transthyretin Amyloid Cardiomyopathy in Latin America: A questionnaire-based cross-sectional study. 
    Camacho-Hubner, Cecilia; Waddington Cruz, Marcia; Rodríguez González, María Juliana; Simões, Marcus Vinicius; López-Ponce de León, Juan David; Fernandes, Fabio; Martínez Carreño, Erika María; Costabel, Juan Pablo; Berríos Bárcenas, Enrique A.; Barroso, Fabio Adrián; Cigarroa López, José Angel; Ortega Reyes, Rosa; Alvarez, Jaime; Pérez de Arenaza, Diego; Buitrago, Diana; Otero, Constanza; Bertoli de Souza, Claudenice Leite; Molina Gómez, Juan Sebastián; Silva Julian, Guilherme (Public Library of Science, 2026-06-26)
    Background: Cardiac Amyloidosis (CA), specifically Transthyretin Amyloid Cardiomyopathy (ATTR-CM), is an under-recognized, progressive, and fatal disease. Comprehensive primary data describing awareness, attitudes, and ...
  • Endovascular embolization of tentorial dural arteriovenous fistulas (EMBOTENT): a retrospective multicenter study 
    Vollherbst, Dominik F.; Krug, Nadja; Zhang, Peng; Ma, Yongjie; Su, Xin; Limbucci, Nicola; Renieri, Leonardo; Mosimann, Pascal J.; Boutet, Alexandre; Cheng, How-Chung; Marnat, Gaultier; Barreau, Xavier; Szikora, Istvan; Czencz, Máté; González, Alejandro; Albóniga-Chindurza, Asier de; Scarcia, Luca; Kalsoum, Erwah; Alexandre, Andrea M.; Pujol Lereis, Virginia Andrea (BMJ Publishing Group, 2026-05-04)
    Background: Tentorial dural arteriovenous fistulas (TDAVFs) are rare but high risk vascular lesions. Although endovascular embolization is often the preferred treatment, large scale data on efficacy and safety are limited. ...
  • Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient 
    Vautier, Mercedes Florencia; Chrem Méndez, Patricio Alexis; Jerez Ferreyra, Guillermo; Massazza, Victoria; Apecetche, Manuela; Rodríguez Varela, María Soledad; Clas, Giulia Solange; Nievas, Micaela; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia; Romorini, Leonardo (Elsevier, 2026-06)
    Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean ...
  • Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study 
    Patel, Maulikkumar; Feng, Wei; McKay, Nicole S.; Millar, Peter R.; Liu, Menghan; Yang, Chengran; Cetin, Arda; Johnson, Matthew; Budde, John P.; Western, Daniel; Marsh, Thomas W.; Saliu, Ibrahim O.; Gordon, Brian A.; Llibre Guerra, Jorge J.; Morris, John C.; Bateman, Randall J.; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Vázquez, Silvia (Lancet, 2026-06)
    Background: Individuals with autosomal dominant Alzheimer's disease (ADAD) arising from mutations in PSEN1, PSEN2, or APP exhibit variability in clinical presentation. Genetic studies of ADAD have shaped our understanding ...
  • Conmociones cerebrales en el fútbol: avances recientes y desafíos en la gestión clínica y preventiva 
    Russo, María Julieta; Salvat, Fernando; Ameriso, Sebastián Francisco; Villani, Donato; Vega, Jorge; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio (Fundación Revista Medicina (Buenos Aires), 2026-08)
    Concussions in soccer are a key challenge for neurological health due to their high incidence, diagnostic complexity, and risk of long-term sequelae. This article provides a narrative review of their definition, epidemiology, ...
  • Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease 
    Morcillo Nieto, Alejandra O.; Franquesa Mullerat, Maria; Zsadanyi, Sara E.; Arriola‐Infante, José Enrique; Vaqué‐Alcázar, Lídia; Rozalem Aranha, Mateus; Allende Parra, José; Zhao, Zili; Arranz, Javier; Rodríguez‐Baz, Íñigo; Maure Blesa, Lucia; Videla, Laura; Barroeta, Isabel; Del Hoyo Soriano, Laura; Benejam, Bessy; Fernández, Susana; Sanjuan Hernandez, Aida; Pertierra, Lucía; Giménez, Sandra; Santos Santos, Miguel Ángel (Wiley, 2026-05-29)
    INTRODUCTION: This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker ...
  • Implementation of stroke prevention: a review of challenges and opportunities in the Americas 
    Ouriques Martins, Sheila Cristina; Ordunez, Pedro; Borelli, Wyllians Vendramini; Ovbiagele, Bruce; Urrutia, Victor C.; Abanto, Carlos; Alet, Matías Javier; Almarie, Bassel; Álvarez, Tony Fabián; Amaya, Pablo; Ameriso, Sebastián Francisco; Arauz-Gongora, Antonio; Barboza, Miguel A.; Bayona, Hernán; Calleja, Juan; Cano Nigenda, Vanessa; Carbonera, Leonardo Augusto; Carrillo Larco, Rodrigo M.; Constanzo, Freddy; Pujol Lereis, Virginia Andrea (Elsevier, 2026-05-22)
    Stroke remains a leading cause of death and disability throughout the Americas, disproportionately impacting low-and middle-income countries and underserved populations. In this review, we examine the status of stroke ...
  • Incidencia de metástasis extra sistema nervioso central en pacientes con gliomas de alto grado: experiencia en una única institución 
    Martí, Maria Trinidad; Salas, Juan Cruz; Bártoli, Julia; Arakaki, Naomi; Cerrato, Sebastián; Yorio, Florencia; Delorme, Ricardo; Muggeri, Alejandro (Academia Argentina de Oncología Clínica, 2026-05-05)
    La incidencia de metástasis extra sistema nervioso central (MESNC) en pacientes con gliomas es baja, del 0.4 al 11% dependiendo del tipo de glioma. No existen reportes acerca de la incidencia en la Argentina. El objetivo ...
  • Reaction to Health Emergencies 
    Allegri, Ricardo Francisco (Springer, 2026-05-01)
    A health emergency is defined as a scenario involving health conditions that pose a risk to humans, resulting in a substantial rise in disease, disability, and death. The most recent health emergency was the last COVID-19 ...
  • Compound Heterozygous Variants in the Phospholipase Gene PNPLA6 Cause Hypopituitarism and Vision Loss 
    Vishnopolska, Sebastian; Liu, James; Camilletti, María Andrea; Martínez Mayer, Julián; Iglesias García, Lucía; Brinkmeier, Michelle; Vaiani, Elisa; Vidal, Sofia Hebe; Ciaccio, Marta; Di Palma, María Isabel; Belgorosky, Alicia; Marti, Marcelo; Hufnagel, Robert B.; Camper, Sally A.; Pérez-Millán, María Inés (Wiley, 2026-06-19)
    NPLA6 is a conserved lysophospholipase essential for maintaining nervous system integrity. Biallelic mutations in PNPLA6 have been identified in individuals with a broad spectrum of disorders that can include ataxia, vision ...
  • Assessment of sports-related concussion in children and adolescents 
    Testa, Nelly; Pochetti, Juliana; Russo, María Julieta (Sociedad Argentina de Pediatría, 2026-09-30)
    Advances in research on sports-related concussions have led to updates in diagnostic and management protocols. This article reviews the recommendations from the Sixth International Consensus Conference on Concussion in ...
  • Update on spontaneous intracranial hypotension 
    Portes Souza, Marcio Nattan; Uribe, Bernardo; Zavala, Lucía; Lopez, Reydmar; Nagel, Vanesa; Calderaro, Marcelo; Edelmuth, Diogo Guilherme (Brazilian Headache Society, 2026-04-20)
    Background Spontaneous intracranial hypotension (SIH) is a secondary headache disorder caused by spontaneous cerebrospinal fluid (CSF) leakage, typically from dural tears, meningeal diverticula, or CSF venous fistulas, ...
  • Epidemiology and risk factors of stroke in the Americas: a comprehensive narrative literature review 
    Sampaio Silva, Gisele; Diestro, Jose Danilo; Tarzi, Christopher; Kishibe, Teruko; Bernabé-Ortiz, Antonio; Carrillo Larco, Rodrigo M.; Ovbiagele, Bruce; Saposnik, Gustavo; Abanto, Carlos; Alet, Matías Javier; Almarie, Bassel; Álvarez, Tony Fabián; Amaya, Pablo; Ameriso, Sebastián Francisco; Arauz, Antonio; Barboza, Miguel A.; Bayona, Hernán; Calleja, Juan; Cano Nigenda, Vanessa; Pujol Lereis, Virginia Andrea (Elsevier, 2026-05-22)
    Stroke remains a leading cause of death and disability across the Americas, disproportionately affecting low- and middle-income countries. According to the 2023 Global Burden of Disease (GBD) Study, the Americas recorded ...
  • Cierre de foramen oval permeable guiado por ecocardiografía intracardíaca: resultados iniciales y descripción de la técnica 
    Magariños, Eduardo; Henestrosa, Germán; Scuteri, Antonio; Romano, Ariel; Sandoval, Carla Elizabeth; Pujol Lereis, Virginia Andrea; Ameriso, Sebastián Francisco (Colegio Argentino de Cardioangiólogos Intervencionistas, 2025)
    Introducción: El cierre percutáneo del foramen oval permeable (FOP) está establecido como tratamiento para prevención secundaria de un nuevo accidente cerebrovascular (ACV) en un grupo seleccionado de pacientes. En este ...
  • Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America 
    Jiménez, Daniel A.; Bagnati, Pablo M.; Flores Montes, Rosa Elena; Fernández, María Laura; Zuno Reyes, Angélica; Aguillón, David; Aláez Versón, Carmen; Becerra Solano, Luis Eduardo; Behrens, María Isabel; Branda, Kelly; Chrem Méndez, Patricio Alexis; Custodio, Nilton; Ducaine, Whitney; Dumois Petersen, Sofía; Figuera, Luis; Londoño Castaño, Marisol; Longoria, Erika Mariana; Matute, Esmeralda; Surace, Ezequiel Ignacio; Programa de asesoramiento genético en América Latina (PRAGA) (Wiley, 2026-05-27)
    Autosomal dominant Alzheimer's disease (ADAD) represents a small but impactful subset of Alzheimer's cases. Asymptomatic individuals at genetic risk face substantial personal and family implications when considering ...
  • Early use of high-efficacy disease-modifying therapies reduces the risk of progression independent of relapse and MRI activity in patients with relapsing-remitting multiple sclerosis 
    Guarnaschelli, María Flor; Marrodán, Mariano; Sosa, Brian Ezequiel; Perez Arana, Carolina I.; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (SAGE, 2026-04-29)
    Background: Progression independent of relapse and MRI activity (PIRMA) is a major contributor to long-term disability in relapsing-remitting multiple sclerosis (RRMS). In Latin America, limited access to high-efficacy ...
  • Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome 
    Giménez, Sandra; Vaqué-Alcázar, Lídia; Clos, Susana; Benejam, Bessy; Carmona-Iragui, María; Maure Blesa, Lucia; Videla, Laura; Zhu, Nuole; Altuna, Miren; Arranz, Javier; Barroeta, Isabel; Rodríguez-Baz, Íñigo; Bejanin, Alexandre; Bueno, Ana; Fernández, Susana; Del Hoyo Soriano, Laura; Pertierra, Lucía; Alcolea, Daniel; Miller, Bruce; Grinberg, Lea T. (Wiley, 2026-05)
    Introduction: Sleep and circadian rest-activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR ...
  • Brucella abortus Infection Promotes Mesenchymal Stem Cell Differentiation Toward Adipogenesis, Enhancing the Proinflammatory Profile 
    Freiberger, Rosa Nicole; López, Cynthia Alicia Marcela; Palma, María Belén; Cevallos, Cintia; Sviercz, Franco Agustin; Jarmoluk, Patricio; García, Marcela Nilda; Quarleri, Jorge; Delpino, María Victoria (MDPI, 2026-04-23)
    The most common complication of active brucellosis in humans is osteoarticular injury. In the bone marrow microenvironment, mesenchymal stem cells (MSCs) can differentiate into either adipocytes or osteoblasts, and this ...
  • ABSTRACT NUMBER: ESOC2026A1514 ADAPTIVE CONTROL ANKLE ROBOTICS INTEGRATED WITH PHYSIOTHERAPY FOR SEVERE HEMIPARESIS IN SUBACUTE STROKE: A CASE REPORT 
    Dossi, Daiana Elizabeth; Gianella, Matías Gabriel; Rivas, María Elisa; Mattei, Martín; Best, María Gabriela; Moya, Diego; Crespo, Marcos José; Hernández, Micaela Anahí; MacKo, Richard; MacKo, Charlene; Ameriso, Sebastián Francisco (Oxford University Press, 2026-03-06)
    Background and aims: Adaptive control ankle robotics is a promising but underexplored strategy for stroke rehabilitation. AMBLE is a wireless impedance-controlled ankle exoskeleton with foot switches that adapt dorsiflexion ...
  • Regression-based normative data for neuropsychological assessment in Buenos Aires, Argentina: RAVLT, trail making test, digit span, and verbal fluency 
    Corvalán, Nicolás; Morello García, Florentina; Leiva, Samanta; Allegri, Ricardo Francisco; Crivelli, Lucía (Cambridge University Press, 2026-05-11)
    Objective: To develop regression-based normative data for a set of widely used neuropsychological tests and to provide a freely accessible normative data calculator for use in Buenos Aires, Argentina. Methods: Participants ...