Repositorio Institucional FLENI: Recent submissions

  • Human development, inequality, and their associations with brain structure across 29 countries 
    Medel, Vicente; Alliende, Luz M.; Bethlehem, Richard; Seidlitz, Jakob; Ringlein, Grace; Arango, Celso; Arnatkevičiūtė, Aurina; Asmal, Laila; Bellgrove, Mark; Benegal, Vivek; Bernardo, Miquel; Billeke, Pablo; Bosch-Bayard, Jorge; Bressan, Rodrigo; Busatto, Geraldo; Chaim-Avancini, Tiffany; Costanzi, Monise; Castro, Mariana Nair; Villarreal, Mirta Fabiana (Cambridge University Press, 2025-07-16)
    Background: The macro-social and environmental conditions in which people live, such as the level of a country's development or inequality, are associated with brain-related disorders. However, the relationship between ...
  • Recognition memory in individuals with mild cognitive impairment and Alzheimer's dementia : a systematic review 
    Russo, María Julieta; Bueri, José; Ferrara, Lucía Alba; Labos, Edith; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis, 2026-01-06)
    Background: Episodic memory impairment is a hallmark of Alzheimer's disease (AD) and is already present in its prodromal stage. While recall deficits are well established as predictors of memory performance, the role of ...
  • Challenges in Launching a Precision Pediatric Oncology Program in Argentina 
    Paladino, María Mercedes; Pinto, Nicolás; Verón, David; Morosini, Fabiana; García Rivello, Hernán; Alves da Quinta, Daniela; Ganiewich, Daiana; Varela, Mariana; Diez, Blanca; de Dávila, María Teresa; Villarroel, Milena; de Sá Rodrigues, Karla Emília; Villanueva, Gabriela; Solorzano, Daniel; Casanovas, Alejandra; Rotondaro, Cecilia; Arrossi, Silvina; Chantada, Guillermo L.; Llera, Andrea S. (John Wiley, 2026-06)
    Background/objectives: Advances in pediatric cancer care have underscored the importance of tumor sequencing for diagnosis and treatment selection. However, access to genomic diagnostics in Latin America remains limited. ...
  • A Decline in Metabotropic Glutamate mGlu3 Receptor Levels Is Associated With Amyloid Plaques in Alzheimer's Disease and Is Detectable in Serum During Mild Cognitive Impairment 
    Olivera, Eugenia; Sáez, Albany; Castro, Micaela; Garaventa, Pilar; Novack, Gisela; Romero, Ana Clara; Bigi, Mercedes; Celaya, Daniela; Mezmezian, Mónica Beatriz; Sevlever, Gustavo Emilio; Saravia, Flavia; Lasaga, Mercedes; Caruso, Carla M.; Palumbo, María Laura; Durand, Daniela (Wiley, 2026-04)
    Subtype 3 metabotropic glutamate receptors (mGlu3R) play neuroprotective roles and are involved in superior executive functions and memory in humans. However, this target has been scarcely studied in the context of Alzheimer's ...
  • Biomechanical Assessment of Orbital Retraction in the Endoscopic Transorbital Approach : A Cadaveric Study 
    Odeibat, Yousef; Gago, Guilherme; Monsalve, Martin; Comeau, Marc-Olivier; Champagne, Pierre-Olivier (Thieme, 2026-02-27)
    Background: The endoscopic transorbital approach (ETOA) provides minimally invasive access to the skull base but requires orbital retraction across key zones to establish a surgical corridor. Retraction is essential for ...
  • Standardizing Surgical Freedom Measurement : A Tool for Objective Comparison of Skull Base Approaches 
    Odeibat, Yousef; Gago, Guilherme; Monsalve, Martin; Agosti, Edoardo; Champagne, Pierre-Olivier (Thieme, 2026-02-27)
    Background: Surgical freedom quantifies proximal instrument maneuverability with fixed distal targets, critical for comparing neurosurgical approaches. Current methods lack standardization, using different geometries without ...
  • Prognostic significance of CDKN2A/B hemizygous deletion in IDH-mutant astrocytomas : a systematic review and meta-analysis 
    Nakasu, Satoshi; Deguchi, Shoichi; Mezmezian, Mónica Beatriz; Mitsuya, Koichi; Notsu, Akifumi; Nakasu, Yoko (Springer-Verlag Tokyo, 2026-03-17)
    The prognostic significance of CDKN2A/B hemizygous deletion (HemD) in IDH-mutant astrocytomas (A-IDHm) remains unclear. We conducted a systematic review and WHO grade-specific meta-analysis of primary tumors following the ...
  • Characterization of individuals fulfilling clinical criteria for limbic-predominant age-related TDP43 encephalopathy (LATE) in a tertiary memory clinic 
    Groot, Colin; Calandri, Ismael Luis; Bader, Ilse; Bocancea, Diana I.; de Bruin, Hannah; Carrigan, Maria; Kamps, Suzie; de Koning, Lotte A.; Mastenbroek, Sophie E.; Rikken, Roos M.; van Tol, Bastiaan G. J.; Vermeiren, Marie R.; Wesseling, Alex; Xia, Ye; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Barkhof, Frederik; Jonkman, Laura E.; van der Lee, Sven J.; de Boer, Casper (Wiley Periodicals LLC on behalf of Alzheimer's Association, 2026-01-07)
    Background Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, ...
  • Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial 
    McCullough, Austin; Chen, Charles D.; Gordon, Brian A.; Joseph-Mathurin, Nelly; Jack Jr, Clifford R; Koeppe, Robert; Hornbeck, Russ; Koudelis, Deborah; McKay, Nicole S.; Hobbs, Diana A.; Flores, Shaney; Keefe, Sarah J.; Aggarwal, Neelum T.; Allegri, Ricardo Francisco; Berman, Sarah B.; Bird, Thomas; Black, Sandra E.; Brooks, William S.; Chhatwal, Jasmeer P.; Day, Gregory S.; DIAN‐TU Study Team (Wiley, 2025-07)
    Introduction: Monoclonal anti-amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose ...
  • Advances in migraine prevention 
    Martinelli, Daniele; De Icco, Roberto; Al-Khazali, Haidar M.; Ashina, Sait; Diener, Hans-Christoph; Dodd-Glover, Freda; Goicochea, María Teresa; Jenkins, Bronwyn; MaassenVanDenBrink, Antoinette; Lee, Mi Ji; Özge, Aynur; Prieto Peres, Mario Fernando; Pozo Rosich, Patricia; Puledda, Francesca; Sacco, Simona; Schwedt, Todd J.; Terwindt, Gisela M.; Tassorelli, Cristina (Lancet Pub. Group, 2026-03)
    Migraine imposes a heavy burden on patients and societies. Preventive treatments aimed at reducing the occurrence of migraine attacks and their intensity have been largely underused, leaving a multitude of people with ...
  • Systematic review of movement disorders mislabeled as functional : when incongruence misleads 
    Marín-Medina, Daniel S.; Miño Zambrano, Joselyn; Espay, Alberto J.; Merello, Marcelo (Springer-Verlag, 2026-04-08)
    Background: Misdiagnosis of functional movement disorders (FMD) remains a concern for clinicians. We sought to review the phenomenology and clinical features associated with FMD misdiagnosis. Methods: We conducted a ...
  • Novel GNAO1 variant in α-helical domain reveals alternative mechanism of disease 
    Ludlam, William Grant; Domínguez-Carral, Jana; Schteinschnaider, Ángeles; Martemyanov, Kirill A.; Ortigoza-Escobar, Juan Darío (Elsevier B.V. on behalf of KeAi Communications Co. Ltd., 2026-03)
    Resumen no disponible.
  • Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease 
    Llibre Guerra, Jorge J.; Lu, Ruijin; Clarens, María Florencia; Liu, Ian; Renton, Alan E.; Ryan, Natalie S.; Goate, Alison M.; Aguillón, David; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Vigo, Gabriela; Cruchaga, Carlos; Day, Gregory S.; Farlow, Martin R.; Fox, Nick C.; Gordon, Brian A.; Hassenstab, Jason (Lippincott Williams & Wilkins, 2026-04-28)
    Background and objectives: Cognitive reserve has been shown to modulate the onset and progression of Alzheimer disease (AD) symptoms. Although its role in sporadic AD is well-studied, how cognitive reserve influences the ...
  • Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome 
    Lim, Timothy Reynold; Suthiphosuwan, Suradech; Gaitán, María Inés; Marrodán, Mariano; Horwath, Elizabeth A.; Guenette, Melanie; Bharatha, Aditya; Sati, Pascal; Absinta, Martina; Correale, Jorge; Shinohara, Russell; Reich, Daniel S.; Oh, Jiwon (American Medical Association, 2026-03)
    Importance: Most people with radiologically isolated syndrome (RIS) have high proportions of white matter lesions (WMLs) demonstrating the central vein sign (ie, central vein sign-positive lesion [CVS+L]) and at least 1 ...
  • Toxina botulínica tipo A en el tratamiento preventivo de la migraña crónica : experiencia en un servicio de cefaleas de Argentina 
    Larripa, Natalia; Grandinetti, Mariela; Calvo, Daniela; Nagel, Vanesa; Goicochea, María Teresa (Fundación Revista Medicina (Buenos Aires), 2026)
    Introducción: La migraña crónica (MC) es una de las enfermedades neurológicas más discapacitantes, con un marcado impacto en la calidad de vida y en la utilización de recursos sanitarios. En Argentina, no existen datos ...
  • Percheron Artery Implicance in Bi-Thalamic Stroke Following Endoscopic Endonasal Approach for Infundibulo-Neurohypophysitis : A Combination of Two Rare Entities 
    Domecq, Lucila; Ruella, Mauro; Villanueva, Pablo Javier; Katz, Débora Adela; Battistone, María Florencia; Cervio, Andrés Eduardo (Turkish Neurosurgical Society, 2026)
    Bi-thalamic stroke is rarely reported in the literature as a complication of an endonasal endoscopic procedure. It has been associated with presence of a Percheron artery variant, as well as with top of the basilar syndrome, ...
  • Neuro-Otologic Manifestations of Multiple Sclerosis 
    Laffue, Alfredo Hernan (Springer, Cham, 2026-02-17)
    Multiple sclerosis is a common demyelinating disease of the central nervous system (CNS) that often presents with vestibular symptoms, including vertigo, nystagmus, and oculomotor disturbances. These manifestations occur ...
  • Early motor response to dopamine replacement therapy in Parkinson's disease patients carrying GBA variants 
    Rossi, Malco Damián; Castillo Torres, Sergio Andrés; Merello, Marcelo (Elsevier, 2022-09-15)
    Background: Mutations in the glucocerebrosidase (GBA) gene represent the most common genetic risk factor for Parkinson's Disease (PD) and are associated with a more aggressive motor phenotype at late stages. However, the ...
  • Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic 
    Groot, Colin; Calandri, Ismael Luis; Bader, Ilse; Bocancea, Diana I.; de Bruin, Hannah; Carrigan, Maria; Collij, Lyduine E.; Duits, Flora H.; Kamps, Suzie; de Koning, Lotte A.; Lemstra, Afina W.; Mastenbroek, Sophie E.; Rikken, Roos M.; van Tol, Bastiaan G. J.; Vermeiren, Marie R.; Wesseling, Alex; Xia, Ye; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Barkhof, Frederik (Lippincott Williams & Wilkins, 2026-05-12)
    Background and objectives: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, ...
  • Recovery of Postural Control and Gait After a Severe Stroke. A Descriptive Study 
    Gath, Christian Federico; Gianella, Matías Gabriel; Gatti, Marcelo Andrés; Rivas, María Elisa (John Wiley & Sons, 2026-01)
    Background and purpose: Research into recovery of postural control after a severe stroke needs to be improved. The objective is to describe postural control at admission and the recovery of postural control during ...

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