Neurología: Recent submissions

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Biomarkers for dementia in Latin American countries: Gaps and opportunities

Parra, Mario A.; Orellana, Paulina; León, Tomás; Cabello, Victoria G.; Henriquez, Fernando; Gomez, Rodrigo; Avalos, Constanza; Damián, Andrés; Slachevsky, Andrea; Ibañez, Agustín; Zetterberg, Henrik; Tijms, Betty M.; Yokoyama, Jennifer S.; Piña-Escudero, Stefanie D.; Cochran, J. Nicholas; Matallana, Diana L.; Acosta, Daisy; Allegri, Ricardo Francisco (John Wiley & Sons, 2022-09-13)

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities ...
Alteration of Fatty Acid Profile in Fragile X Syndrome

Abolghasemi, Armita; Carullo, María Paulina; Cisneros Aguilera, Ester; Laroui, Asma; Plantefeve, Rosalie; Rojas, Daniela; Benachenhou, Serine; Ramírez, María Victoria; Proteau-Lemieux, Mélodie; Lepage, Jean-François; Corbin, François; Plourde, Mélanie; Farez, Mauricio Franco; Cogram, Patricia; Çaku, Artuela (MDPI, 2022-09-16)

Fragile X Syndrome (FXS) is the most prevalent monogenic cause of Autism Spectrum Disorders (ASDs). Despite a common genetic etiology, the affected individuals display heterogenous metabolic abnormalities including ...
Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease

Vöglein, Jonathan; Franzmeier, Nicolai; Morris, John C.; Dieterich, Marianne; McDade, Eric; Simon, Mikael; Preische, Oliver; Hofmann, Anna; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2022-05-24)

Introduction: As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ...
CSF Findings in Relation to Clinical Characteristics, Subtype, and Disease Course in Patients With Guillain-Barré Syndrome

Al-Hakem, Helle; Doets, Alex Y.; Stino, Amro Maher; Zivkovic, Sasha A.; Andersen, Henning; Willison, Hugh J.; Cornblath, David R.; Gorson, Kenneth C.; Islam, Zhahirul; Mohammad, Quazi Deen; Sindrup, Soren H.; Kusunoki, Susumu; Davidson, Amy; Casasnovas, Carlos; Bateman, Kathleen J.; Miller, James A. L.; Van den Berg, Bianca; Verboon, Christine; Roodbol, Joyce; Barroso, Fabio Adrián (Lippincott Williams & Wilkins, 2023-04-19)

Background and Objectives To investigate CSF findings in relation to clinical and electrodiagnostic subtypes, severity, and outcome of Guillain-Barré syndrome (GBS) based on 1,500 patients in the International GBS Outcome ...
An Exploratory Study of Sleep-Wake Differences of Autonomic Activity in Patients with Mild Cognitive Impairment: The Role of Melatonin as a Modulating Factor

Abulafia, Carolina; Vidal, María Florencia; Olivar, Natividad; Odzak, Andrea; Brusco, Luis Ignacio; Guinjoan, Salvador Martín; Cardinali, Daniel P.; Vigo, Daniel Eduardo (Dove Medical Press, 2023-05-12)

Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to ...
Rapidly Progressive Atypical Parkinsonism as a Presenting Feature of ATX- CACNA1G (SCA42)

Martínez Villota, Viviana Alexandra; Castillo Torres, Sergio Andrés; Rossi, Malco Damián; Merello, Marcelo (Wiley, 2023-02-21)

Resumen no disponible.
Guía de práctica clínica: tratamiento agudo de las enfermedades inflamatorio-desmielinizantes del sistema nervioso central: esclerosis múltiple, espectro de la neuromielitis óptica, encefalomielitis diseminada aguda, enfermedades asociadas a anticuerpos antiglicoproteína de la membrana del oligodendrocito, mielitis aguda y neuritis óptica. Elaborada por el Grupo de Trabajo de Enfermedades Desmielinizantes. Sociedad Neurológica Argentina

Hryb, Javier Pablo; Tavolini, Darío; Pagani Cassará, Fátima; Silva, Berenice Anabel; Rojas, Juan Ignacio; Sinay, Vladimiro; Tkachuk, Verónica A.; Alonso, Ricardo; Carnero Contentti, Edgar; Ysrraelit, María Célica; Cohen, Leila; Rotta Escalante, Roberto; Mainella, Carolina; Diana Martínez, Alejandra; Liwacki, Susana; Luetic, Geraldine G.; Bestoso, Santiago; Vázquez, Guido; Piedrabuena, Raúl; Vrech, Carlos (Elsevier, 2023-06-12)

Introducción El tratamiento adecuado y a tiempo de las manifestaciones agudas de las enfermedades inflamatorias-desmielinizantes del sistema nervioso central incluyendo a la encefalomielitis diseminada aguda, los síndromes ...
Long-term follow-up of patients with relapsing multiple sclerosis from the CLARITY/CLARITY Extension cohort of CLASSIC-MS: An ambispective study

Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; Verdun di Cantogno, Elisabetta (Sage, 2023-04-03)

Background: CLASSIC-MS evaluated the long-term efficacy of cladribine tablets in patients with relapsing multiple sclerosis. Objective: Report long-term mobility and disability beyond treatment courses received in ...
Estrategias de manejo de terapias de alta eficacia para esclerosis múltiple en la práctica clínica

Barboza, Andrés G.; Correale, Jorge; Alonso, Ricardo; Burgos, Marcos; Cáceres, Fernando; Carnero Contentti, Edgar; Carrá, Adriana; Cristiano, Edgardo; Fiol, Marcela Paula; Garcea, Orlando; Luetic, Geraldine G.; Patrucco, Liliana; Piedrabuena, Raúl; Rojas, Juan Ignacio; Silva, Berenice Anabel; Sinay, Vladimiro; Vrech, Carlos; Ysrraelit, María Célica (Elsevier, 2023-06-12)

Introducción En la actualidad existe un importante número de opciones en terapias modificadoras de la enfermedad en esclerosis múltiple (EM), las cuales pueden ser categorizadas como de baja, moderada y alta eficacia según ...
"Pandemic Fatigue" in South America: A Multi-Center Report from Argentina, Bolivia, Paraguay, Peru, and Uruguay

Torales, Julio César; González-Urbieta, Israel; Barrios Coronel, Iván; Waisman Campos, Marcela; Terrazas-Landivar, Alexandra; Viola, Laura; Caycho-Rodríguez, Tomás; Melgarejo, Osvaldo; Navarro, Rodrigo Eduardo; García, Oscar; Almirón Santacruz, José; Castaldelli-Maia, João Mauricio; Ventriglio, Antonio (MDPI, 2023-03-04)

The COVID-19 pandemic has had a heavy impact on daily life, leading to physical and psychosocial consequences. Nowadays, clinicians and health researchers are particularly interested in describing and facing the long-term ...
Design of a Non-Interventional Study to Assess Neurologists' Perspectives and Pharmacological Treatment Decisions in Early Alzheimer's Disease

Saposnik, Gustavo; Sánchez-Benavidez, Gonzalo; García-Arcelay, Elena; Franco-Macías, Emilio; Bensi, Catalina; Carmelingo, Sebastián; Allegri, Ricardo Francisco; Pérez-Martíne, David A.; Maurino, Jorge (Springer, 2023-03-23)

Introduction: The current therapeutic landscape of Alzheimer's disease (AD) is evolving rapidly. Our treatment options include new anti-amyloid-β protein disease-modifying therapies (DMTs) that decrease cognitive decline ...
AD-causing variants that affect PSEN1 transmembrane domains are associated with faster neurodegeneration and cognitive decline compared to those affecting cytoplasmic domains

Schultz, Stephanie A.; Allegri, Ricardo Francisco; Schultz, Aaron P.; Goate, Alison M.; Levey, Allan I.; Fagan, Anne M.; Hanseeuw, Bernard J.; Koeppe, Robert A.; Gordon, Brian A.; Cruchaga, Carlos; Karch, Celeste M.; Chen, Charles D.; Xiong, Chengjie; Jack Jr, Clifford R.; Fitzpatrick, Colleen D.; McDade, Eric; Chui, Helena C.; Mori, Hiroshi; Lee, Jae-Hong; Noble, James M. (Wiley, 2022-12)

Background Rates of cognitive and biomarker change in Autosomal Dominant Alzheimer disease (ADAD) vary substantially across individuals. Prior cross-sectional work suggests that the location of the pathogenic variant ...
Infarto cerebeloso bilateral simultáneo en un paciente con fibrilación auricular paroxística no valvular: una presentación atípica

Peñarete-Nader, Rafael; Barrios-Herrera, Jennifer; Terroba Chambi, Cinthia; Salcedo-Pérez, Luis; Duque-Guidales, Laura (Sociedad Ecuatoriana de Neurología, 2022)

Introducción: Los infartos cerebelosos ocurren habitualmente en el territorio de la arteria cerebelosa posteroinferior (PICA) y suelen ser predominantemente unilaterales. El compromiso simultáneo bilateral de la arteria ...
Performance of McDonald 2017 multiple sclerosis diagnostic criteria and evaluation of genetic ancestry in patients with a first demyelinating event in Argentina

Marrodán, Mariano; Piedrabuena, María Agustina; Gaitán, María Inés; Fiol, Marcela Paula; Ysrraelit, María Célica; Carnero Contentti, Edgar; López, Pablo Adrián; Peuchot, Verónica; Correale, Jorge (Sage, 2023-03-21)

Background: Information on performance of multiple sclerosis (MS) diagnostic criteria is scarce for populations from Latin America, Asia, or the Caribbean. Objective: To assess performance of revised 2017 McDonald ...
The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

Maestre, Gladys; Carrillo, María C.; Kalaria, Raj; Acosta, Daisy; Adams, Larry; Adoukonou, Thierry; Akinwande, Kazeem; Akinyemi, Joshua; Akinyemi, Rufus; Akpa, Onoja; Alladi, Suvarna; Allegri, Ricardo Francisco; Arizaga, Raul; Arshad, Faheem; Arulogun, Oyedunni; Babalola, David; Baiyewu, Olusegun; Bak, Thomas; Bellaj, Tarek; African Dementia Consortium (John Wiley & Sons, 2023-03-11)

Resumen no disponible
Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up

Nguyen, Thanh N.; Qureshi, Muhammad M.; Klein, Piers; Yamagami, Hiroshi; Mikulik, Robert; Czlonkowska, Anna; Abdalkader, Mohamad; Sedova, Petra; Sathya, Anvitha; Lo, Hannah C.; Yassin Mansour, Ossama; Vanguru, Husitha Reddy; Lesaine, Emilie; Tsivgoulis, Georgios; Loochtan, Aaron I.; Demeestere, Jelle; Uchino, Ken; Inoa, Violiza; Goyal, Nitin; Pujol Lereis, Virginia Andrea (Lippincott Williams & Wilkins, 2022-10-18)

Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term ...
Motor assessment of patients with multiple system atrophy: underuse of the Unified Multiple System Atrophy Rating Scale (UMSARS)

Ferreirós, Alexandra; Castillo Torres, Sergio Andrés; Merello, Marcelo (Steinkopff, 2023-03-27)

Purpose: Despite the availability of the Unified Multiple System Atrophy (MSA) Rating Scale (UMSARS) for almost two decades, studies still use scales developed for Parkinson's disease (PD) or ataxia (ATX). Our aim was to ...
Are highly active and aggressive multiple sclerosis the same entity?

Correale, Jorge; Rush, Carolina A.; Barboza, Andrés G. (Frontiers Research Foundation, 2023-03-03)

Resumen no disponible.
Editors Note: Looking Forward, Looking Back

Merello, Marcelo; Bhatia, Kailash P. (Wiley, 2022-12-09)
Incidence and case-fatality rate of stroke in General Villegas, Buenos Aires, Argentina. The EstEPA population study

Ameriso, Sebastián Francisco; Alet, Matías Javier; Rosales, Julieta Soledad; Rodriguez Pérez, María Soledad; Povedano, Guillermo Pablo; Pujol Lereis, Virginia Andrea; Rodríguez Lucci, Federico; Dossi, Daiana Elizabeth; González, Claudio D.; Melcon, Mario O. (Saunders, 2023-03-20)

Objectives: Stroke epidemiology varies among different populations. The burden of stroke is high in low- and middle-income countries. Reliable population data is needed to assess the impact of stroke and to develop policies ...

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