Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer Association (AA) criteria for AD furthers this ...
Introduction: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice ...
Espeland, Mark A.; Demesie, Yitbarek N.; Olson, Kay Loni; Lockhart, Samuel N.; Tomaszewski Farias, Sarah E.; Cleveland, Maryjo L.; Tangney, Christy C.; Crivelli, Lucía; Snyder, Heather M.; York, Michele K.; Baker, Laura D.; Whitmer, Rachel A.; Wing, Rena R.; Garcia, Katelyn R.; Callahan, Kathryn E.; U.S. POINTER Research Group(Oxford University, 2024-11-16)
Background: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty ...
In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
Biomarkers have been instrumental in population selection and disease monitoring in clinical trials of recently FDA-approved drugs targeting amyloid-β to slow the progression of Alzheimer's disease (AD). As new therapeutic ...
Background: Clinical diagnosis in primary progressive aphasia (PPA) is challenging. Recently, emphasis has been placed on the importance of screening evaluation. Three different screening tests that use different strategies ...
Cubas Guillen, Jonathan Fernando; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Martin, María Eugenia; Clarens, María Florencia; Russo, María Julieta; Harris, Paula; Egido, Noelia; Tapajóz Pereira de Sampaio, Fernanda; Chaves, Hernán; Vázquez, Silvia; Martinetto, Horacio; Campos, Jorge; Calandri, Ismael Luis; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco(John Wiley & Sons, 2024-10-06)
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has fostered collaboration among researchers around the world, catalyzing innovation and accelerating progress in the field. In Latin America, this initiative advanced ...
Carrera Silva, Eugenio Antonio; Correale, Jorge; Rothlin, Carla; Ortiz Wilczyñski, Juan Manuel(American Society for Pharmacology and Experimental Therapeutics, 2024-10-08)
Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based ...
Vermunt, Lisa; Sutphen, Courtney L.; Dicks, Ellen; de Leeuw, Diederick M.; Allegri, Ricardo Francisco; Berman, Sarah B.; Cash, David M.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Day, Gregory S.; Ewers, Michael; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Graff-Radford, Neill R.; Hassenstab, Jason; Jucker, Mathias; Karch, Celeste M.; Kuhle, Jens; Laske, Christoph(Oxford University Press, 2024-10-09)
The grey matter of the brain develops and declines in coordinated patterns during the lifespan. Such covariation patterns of grey matter structure can be quantified as grey matter networks, which can be measured with ...
Sewell, Kelsey R.; Doecke, James D.; Xiong, Chengjie; Benzinger, Tammie; Masters, Colin L.; Laske, Christoph; Jucker, Mathias; Lopera, Francisco; Gordon, Brian A.; Llibre-Guerra, Jorge; Levin, Johannes; Huey, Edward D.; Hassenstab, Jason; Schofield, Peter R.; Day, Gregory S.; Fox, Nick C.; Chhatwal, Jasmeer; Ibanez, Laura; Roh, Jee Hoon; Perrin, Richard; Lee, Jae-Hong; Allegri, Ricardo Francisco; Supnet-Bell, Charlene; Berman, Sarah B.; Daniels, Alisha; Noble, James; Martins, Ralph N.; Rainey-Smith, Stephanie; Peiffer, Jeremiah; Gardener, Samantha L.; Bateman, Randall J.; Morris, John C.; McDade, Eric; Erickson, Kirk I.; Sohrabi, Hamid R.; Brown, Belinda M.; Dominantly Inherited Alzheimer's Network(Wiley, 2024-09-26)
Introduction: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations.
Methods: Participants ...
Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine ...
In recent years, there has been significant advancement in the utilization of magnetic resonance imaging (MRI) for the diagnostic evaluation of patients with multiple sclerosis (pwMS). The 2017 McDonald criteria have ...
Correale, Jorge; Solomon, Andrew J.; Cohen, Jeffrey A.; Banwell, Brenda L.; Gracia, Fernando; Gyang, Tirisham V.; Diaz de Bedoya, Fernando Hamuy; Harnegie, Mary P.; Hemmer, Bernhard; Jacob, Anu; Kim, Ho Jin; Marrie, Ruth Ann; Matee, Farrah J.; Newsome, Scott D.; Pandit, Lekha; Prayoonwiwat, Naraporn; Sahraian, Mohammad A.; Sato, Douglas K.; Saylor, Deanna; Shi, Fu-Dong; Siva, Aksel; Tan, Kevin; Viswanathan, Shanthi; Wattjes, Mike P.; Weinshenker, Brian; Yamout, Bassem; Fujihara, Kazuo(Lancet Pub. Group, 2024-10)
The differential diagnosis of multiple sclerosis can present specific challenges in patients from Latin America, Africa, the Middle East, eastern Europe, southeast Asia, and the Western Pacific. In these areas, environmental ...
Evidence from both epidemiological and experimental studies, implicate infections present during childhood and young adulthood to the development and/or exacerbation of MS. Possible infectious agents include Epstein–Barr ...
Khedr, Eman M.; Al-Attar, Ghada; Rosales, Julieta Soledad; Sampaio Silva, Gisele; Sebastian, Ivy Anne; Orjuela, Karen D.; de Souza, Ana Cláudia(Lippincott Williams & Wilkins, 2024-08-22)
Estimates of the spectrum and frequency of pathogenic variants in Parkinson's disease (PD) in different populations are currently limited and biased. Furthermore, although therapeutic modification of several genetic targets ...
Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).
Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to ...
Introduction: Among stroke patients with atrial fibrillation (AF), it is not uncommon to identify carotid atherosclerosis. This study aimed to estimate the prevalence of, and factors associated with, carotid atherosclerosis ...