• Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation 

  Dubois, Bruno; Villain, Nicolas; Schneider, Lon; Fox, Nick; Campbell, Noll; Galasko, Douglas; Kivipelto, Miia; Jessen, Frank; Hanseeuw, Bernard; Boada, Mercè; Barkhof, Frederik; Nordberg, Agneta; Froelich, Lutz; Waldemar, Gunhild; Frederiksen, Kristian Steen; Padovani, Alessandro; Planche, Vincent; Rowe, Christopher; Bejanin, Alexandre; Allegri, Ricardo Francisco (American Medical Association, 2024-11-01)

  Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer Association (AA) criteria for AD furthers this ...
• Personal social network strengthens adherence to lifestyle changes in individuals with subjective cognitive decline 

  Calandri, Ismael Luis; Ardohain, Carolina; Elgani, Sofia A.; Seminara, Emiliana; Hernandez, Micaela Anahí; Ossenkoppele, Rik; Allegri, Ricardo Francisco (Wiley, 2024-11-19)

  Introduction: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice ...
• Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the US POINTER Trial 

  Espeland, Mark A.; Demesie, Yitbarek N.; Olson, Kay Loni; Lockhart, Samuel N.; Tomaszewski Farias, Sarah E.; Cleveland, Maryjo L.; Tangney, Christy C.; Crivelli, Lucía; Snyder, Heather M.; York, Michele K.; Baker, Laura D.; Whitmer, Rachel A.; Wing, Rena R.; Garcia, Katelyn R.; Callahan, Kathryn E.; U.S. POINTER Research Group (Oxford University, 2024-11-16)

  Background: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty ...
• CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease 

  Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John; Do, Anh; Liu, Haiyan; Gordon, Brian; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)

  In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
• Insights into the use of biomarkers in clinical trials in Alzheimer's disease 

  Pascoal, Tharick A.; Aguzzoli, Cristiano S.; Lussier, Firoza Z.; Crivelli, Lucía; Suemoto, Claudia K.; Fortea, Juan; Rosa Neto, Pedro; Zimmer, Eduardo R.; Ferreira, Pamela C. L.; Bellaver, Bruna (Elsevier, 2024-10-03)

  Biomarkers have been instrumental in population selection and disease monitoring in clinical trials of recently FDA-approved drugs targeting amyloid-β to slow the progression of Alzheimer's disease (AD). As new therapeutic ...
• Comparative accuracy of Mini-Linguistic State Examination, Addenbrooke's Cognitive Examination, and Depistage Cognitif de Quebec for the diagnosis of primary progressive aphasia 

  Fernández Romero, Lucía; Morello García, Florentina; Laforce Jr, Robert; Delgado Alonso, Cristina; Delgado Álvarez, Alfonso; Gil Moreno, María José; Lavoie, Monica; Cuetos, Fernando; Matias Guiu, Jordi A.; Matias Guiu, Jorge (SAGE, 2024-10-17)

  Background: Clinical diagnosis in primary progressive aphasia (PPA) is challenging. Recently, emphasis has been placed on the importance of screening evaluation. Three different screening tests that use different strategies ...
• Need to adapt Alzheimer's disease criteria in Latin America. 

  Custodio, Nilton; Allegri, Ricardo Francisco; Lopera, Francisco; Caramelli, Paulo (John Wiley & Sons, 2024-10-06)
• Argentina-Alzheimer's Disease Neuroimaging Initiative: pioneering Alzheimer's Research in Latin America and its Implications for Regional Advancement 

  Cubas Guillen, Jonathan Fernando; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Martin, María Eugenia; Clarens, María Florencia; Russo, María Julieta; Harris, Paula; Egido, Noelia; Tapajóz Pereira de Sampaio, Fernanda; Chaves, Hernán; Vázquez, Silvia; Martinetto, Horacio; Campos, Jorge; Calandri, Ismael Luis; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (John Wiley & Sons, 2024-10-06)

  The Alzheimer's Disease Neuroimaging Initiative (ADNI) has fostered collaboration among researchers around the world, catalyzing innovation and accelerating progress in the field. In Latin America, this initiative advanced ...
• New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis 

  Carrera Silva, Eugenio Antonio; Correale, Jorge; Rothlin, Carla; Ortiz Wilczyñski, Juan Manuel (American Society for Pharmacology and Experimental Therapeutics, 2024-10-08)

  Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based ...
• Axonal damage and inflammation response are biological correlates of decline in small-world values: a cohort study in autosomal dominant Alzheimer's disease 

  Vermunt, Lisa; Sutphen, Courtney L.; Dicks, Ellen; de Leeuw, Diederick M.; Allegri, Ricardo Francisco; Berman, Sarah B.; Cash, David M.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Day, Gregory S.; Ewers, Michael; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Graff-Radford, Neill R.; Hassenstab, Jason; Jucker, Mathias; Karch, Celeste M.; Kuhle, Jens; Laske, Christoph (Oxford University Press, 2024-10-09)

  The grey matter of the brain develops and declines in coordinated patterns during the lifespan. Such covariation patterns of grey matter structure can be quantified as grey matter networks, which can be measured with ...
• Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease 

  Sewell, Kelsey R.; Doecke, James D.; Xiong, Chengjie; Benzinger, Tammie; Masters, Colin L.; Laske, Christoph; Jucker, Mathias; Lopera, Francisco; Gordon, Brian A.; Llibre-Guerra, Jorge; Levin, Johannes; Huey, Edward D.; Hassenstab, Jason; Schofield, Peter R.; Day, Gregory S.; Fox, Nick C.; Chhatwal, Jasmeer; Ibanez, Laura; Roh, Jee Hoon; Perrin, Richard; Lee, Jae-Hong; Allegri, Ricardo Francisco; Supnet-Bell, Charlene; Berman, Sarah B.; Daniels, Alisha; Noble, James; Martins, Ralph N.; Rainey-Smith, Stephanie; Peiffer, Jeremiah; Gardener, Samantha L.; Bateman, Randall J.; Morris, John C.; McDade, Eric; Erickson, Kirk I.; Sohrabi, Hamid R.; Brown, Belinda M.; Dominantly Inherited Alzheimer's Network (Wiley, 2024-09-26)

  Introduction: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. Methods: Participants ...
• Population attributable fractions for risk factors for dementia in seven Latin American countries: an analysis using cross-sectional survey data 

  Paradela, Regina Silva; Calandri, Ismael Luis; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; Crivelli, Lucìa; Yaffe, Kristine; Cleusa P Ferri, Cleusa P.; Mukadam, Naaheed; Livingston, Gill; Suemoto, Claudia Kimie (Elsevier, 2024-10)

  Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine ...
• Chapter 2 - Novel imaging approaches in multiple sclerosis. 

  Farez, Mauricio Franco (Elsevier, 2024)

  In recent years, there has been significant advancement in the utilization of magnetic resonance imaging (MRI) for the diagnostic evaluation of patients with multiple sclerosis (pwMS). The 2017 McDonald criteria have ...
• Differential diagnosis of suspected multiple sclerosis: global health considerations 

  Correale, Jorge; Solomon, Andrew J.; Cohen, Jeffrey A.; Banwell, Brenda L.; Gracia, Fernando; Gyang, Tirisham V.; Diaz de Bedoya, Fernando Hamuy; Harnegie, Mary P.; Hemmer, Bernhard; Jacob, Anu; Kim, Ho Jin; Marrie, Ruth Ann; Matee, Farrah J.; Newsome, Scott D.; Pandit, Lekha; Prayoonwiwat, Naraporn; Sahraian, Mohammad A.; Sato, Douglas K.; Saylor, Deanna; Shi, Fu-Dong; Siva, Aksel; Tan, Kevin; Viswanathan, Shanthi; Wattjes, Mike P.; Weinshenker, Brian; Yamout, Bassem; Fujihara, Kazuo (Lancet Pub. Group, 2024-10)

  The differential diagnosis of multiple sclerosis can present specific challenges in patients from Latin America, Africa, the Middle East, eastern Europe, southeast Asia, and the Western Pacific. In these areas, environmental ...
• Chapter 3 - Effect of infections on multiple sclerosis 

  Correale, Jorge; Marrodán, Mariano (Elsevier, 2024)

  Evidence from both epidemiological and experimental studies, implicate infections present during childhood and young adulthood to the development and/or exacerbation of MS. Possible infectious agents include Epstein–Barr ...
• The Risk of Multiple Sclerosis Relapse After Vaccination: Can a Population-Based Study of Mass Vaccination End the Longstanding Debate? 

  Abboud, Hesham; Farez, Mauricio Franco (Lippincott Williams & Wilkins, 2024-08-10)
• Strategies to Advance Stroke Care in Women: An International Conversation. 

  Khedr, Eman M.; Al-Attar, Ghada; Rosales, Julieta Soledad; Sampaio Silva, Gisele; Sebastian, Ivy Anne; Orjuela, Karen D.; de Souza, Ana Cláudia (Lippincott Williams & Wilkins, 2024-08-22)
• Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study 

  Westenberger, Ana; Skrahina, Volha; Usnich, Tatiana; Beetz, Christian; Vollstedt, Eva-Juliane; Laab, Björn-Hergen; Paul, Jefri J.; Curado, Filipa; Skobalj, Snezana; Gaber, Hanaa; Olmedillas, María; Bogdanovic, Xenia; Ameziane, Najim; Schell, Nathalie; Aasly, Jan Olav; Afshari, Mitra; Agarwal, Pinky; Aldred, Jason; Alonso Frech, Fernando; Anderson, Roderick; Merello, Marcelo (Oxford University Press, 2024-08-01)

  Estimates of the spectrum and frequency of pathogenic variants in Parkinson's disease (PD) in different populations are currently limited and biased. Furthermore, although therapeutic modification of several genetic targets ...
• Telomere length as a biomarker in multiple sclerosis 

  Piedrabuena, María Agustina; Correale, Jorge; Farez, Mauricio Franco; Rodríguez Murúa, Sofía; Martínez Canyazo, Carlos; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (SAGE Publications, 2024-09-09)

  Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS). Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to ...
• Prevalence and Factors Associated with Carotid Stenosis in Acute Ischemic Stroke Patients with Atrial Fibrillation 

  Sagris, Dimitrios; Korompoki, Eleni; Strambo, Davide; Mavraganis, Georgios; Michel, Patrik; Eskandari, Ashraf; Vemmos, Konstantinos; Lastras, Clara; Rodriguez Pardo, Jorge; Fuentes, Blanca; Díez Tejedor, Exuperio; Tiili, Paula; Lehto, Mika; Putaala, Jukka; Cuadrado Godia, Elisa; Farington Terrero, Esmirna; Arauz, Antonio; Kamel, Hooman; Rosales, Julieta Soledad; Rodríguez Pérez, María Soledad; Gómez Schneider, Maia; Barboza, Miguel; Tsiskaridze, Alexander; Ntaios, George (Karger, 2024-07-09)

  Introduction: Among stroke patients with atrial fibrillation (AF), it is not uncommon to identify carotid atherosclerosis. This study aimed to estimate the prevalence of, and factors associated with, carotid atherosclerosis ...

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