Background: Levodopa-induced dyskinesias (LIDs) are an important burden for patients with Parkinson's disease (PD), yet their mechanisms remain incompletely understood.
Objective: The objective of this study was to ...
Vitturi, Bruno Kusznir; Cellerino, Maria; Boccia, Daniele; Leray, Emmanuelle; Correale, Jorge; Dobson, Ruth; van der Mei, Ingrid; Fujihara, Kazuo; Inglese, Matilde(Wiley, 2025-10-28)
Background: We aimed to provide updated evidence from the current literature regarding pediatric environmental factors associated with the risk of developing multiple sclerosis (MS).
Methods: Articles were searched in ...
Objective:
We tested the SmartRehab efficacy, usability, and feasibility for stroke rehabilitation across seven countries.
Background:
Stroke is a major cause of disability worldwide. Timely and personalized rehabilitation ...
Russo, María Julieta; Sampayo, María de la Paz; Arias, Paula; García, Vanina; Gambero, Yanina; Maiarú, Mariano; Deschle, Florencia; Pavón, Hernán(MDPI, 2025-10-07)
Background: The Coma Recovery Scale-Revised (CRS-R) is the gold standard for diagnosing chronic disorders of consciousness (DoC); however, its clinical utility is limited by lengthy administration and the need for specialized ...
Oomens, Julie E.; Vos, Stephanie Jb; Maserejian, Nancy N.; Boada, Mercè; Didic, Mira; Engelborghs, Sebastiaan; Fladby, Tormod; van der Flier, Wiesje M.; Frisoni, Giovanni B.; Fröhlich, Lutz; Gill, Kiran Dip; Grimmer, Timo; Hort, Jakub; Allegri, Ricardo Francisco; Alzheimer's Disease Neuroimaging Initiative (ADNI); A4 Study group; Dominantly Inherited Alzheimer Network (DIAN); European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI); Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE); Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group(Sage, 2025-11-13)
BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking ...
Pontes-Neto, Octávio M.; Noble-Lugo, Alejandra; Montenegro Arenas, Ana Cristina; de Campos Guerra, Joao Carlos; Ceresetto, Jose Manuel; Rosales, Julieta Soledad; Colunga-Lozano, Luis Enrique; Meillon-Garcia, Luis Antonio; Vargas Tellez, Luis Eduardo; Dos Reis Rodrigues, Roseny; Gibler, W. Brian; Kreitzer, Natalie P.(Elsevier, 2025-05-05)
Background: Bleeding is the most important complication associated with anticoagulants. Patients experiencing bleeding while on an anticoagulation require proper risk stratification, which involves careful assessment of ...
Piedrabuena, María Agustina; Correale, Jorge; Silva, Berenice; Fiol, Marcela; Marrodán, Mariano; Zárate, María Agustina; Heriz, Alejandra; Ayerbe, Jeremías; Míguez, Jimena; Pita, Cecilia; Lázaro, Luciana; Casas, Magdalena; López, Pablo Adrián; Tkachuk, Verónica; Balbuena, María Eugenia; Nadur, Débora; Liwacki, Susana; Luetic, Geraldine; Burgos, Marcos; Ysrraelit, María Célica(Elsevier, 2025-11-15)
Background: Despite an aging multiple sclerosis (MS) population, clinical outcomes and long-termeffects of disease-modifying therapies in patients aged ≥50 years remain under-studied.
Objective: To compare the efficacy ...
Martínez de Sucre, M. Nahuel; Bianchi, Gianfranco; Wilken, Miguel; Cruz Molina, Cecilia; Noel, Gabriel; Andrés, Daniela(Springer, 2025-10-16)
Parkinson’s disease (PD) is characterized by progressive motor and sensorimotor deficits, including impairments in proprioception and grip force control. Despite their clinical relevance, these alterations are rarely ...
Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge(MDPI, 2025-09-30)
Therapeutic plasma exchange (TPE) is increasingly recognized as a critical escalation therapy for managing acute multiple sclerosis (MS) relapses refractory to high-dose corticosteroids. Neuropathological and clinical ...
Background and objectives: Anti-N-Methyl-d-aspartate receptor encephalitis (NMDARE) is the most prevalent autoimmune encephalitis, primarily affecting young females. Its clinical heterogeneity, particularly in underrepresented ...
Marcora, María S.; Katz, Maximiliano J.; Galo, Azul; Bochicchio, Pablo; Bongiovanni, Vinicius; Bodín, Diego H.; Pagani, Mario R.; Correale, Jorge; Pasquini, María J.(Wiley, 2025-11-10)
Iron deficiency (ID) is the most common micronutrient deficiency globally. ID in pre- and post-natal periods has been associated with impaired neurological development and altered behavior, which may persist despite iron ...
Objectives: For the past five years, COVID-19 has not only been a priority for health planning but also a hotspot for clinical research. Yet, the weight of the worldwide COVID-19 pandemic arises from the critical phase ...
Introduction: Timely diagnosis of schizophrenia is essential to ensure prompt treatment initiation and adherence. Structural magnetic resonance imaging (sMRI), when combined with artificial intelligence (AI), offers a ...
BackgroundPathogenic variants in PSEN1, PSEN2, or AβPP cause early-onset Alzheimer's disease (EOAD). Several novel variants remain of uncertain significance (VUS) due to limited evidence. The PSEN1 p.R358P variant has not ...
Bottino, Marina; Boyer, Monica; Steenari, Maija R.; Barrick, Rebekah; Abdenur, Jose E.(Elsevier, 2025-10-10)
Pyridoxine-Dependent Epilepsy (PDE) is an autosomal recessive disorder caused by biallelic variants in ALDH7A1. The most common presentation is intractable seizures in the neonatal/early infantile period, which respond to ...
Berrios, Waleska; Deschle, Florencia; Caporale, Sofía; Di Fonzo, Guido; Moreno, María Cecilia; Saglio, María Laura; Cervino, Cecilia Verónica; Povedano, Guillermo(Polemos, 2025-10-10)
Introducción: La queja cognitiva subjetiva (QCS) se refiere a la percepción de alteraciones cognitivas en individuos con rendimiento normal en pruebas neuropsicológicas. Las QCS están asociadas con un mayor riesgo de ...
Background: MDS-UPDRS Severity Levels (SLs), derived from clinician- and patient-rated scales, remain underused to evaluate response to subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson's disease ...
Adell, Matias F.; Balda, Javier; Casas, Facundo; D’Giano, Carlos; Quintero-Rincón, Antonio(Instituto de Investigación en Informática, 2025-06)
Epilepsy is a common neurological disorder diagnosed and monitored through EEG recordings. Accurate spike-and-wave (SW) pattern classification is crucial for distinguishing this epileptic seizure disorder from normal brain ...
Background: The Lancet Commission on dementia prevention, intervention, and care 2024 updated the list of modifiable risk factors to include 14 factors. The potential for dementia prevention seems to be greater in low- and ...