• Axonal damage and inflammation response are biological correlates of decline in small-world values: a cohort study in autosomal dominant Alzheimer's disease 

  Vermunt, Lisa; Sutphen, Courtney L.; Dicks, Ellen; de Leeuw, Diederick M.; Allegri, Ricardo Francisco; Berman, Sarah B.; Cash, David M.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Day, Gregory S.; Ewers, Michael; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Graff-Radford, Neill R.; Hassenstab, Jason; Jucker, Mathias; Karch, Celeste M.; Kuhle, Jens; Laske, Christoph (Oxford University Press, 2024-10-09)

  The grey matter of the brain develops and declines in coordinated patterns during the lifespan. Such covariation patterns of grey matter structure can be quantified as grey matter networks, which can be measured with ...
• Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease 

  Sewell, Kelsey R.; Doecke, James D.; Xiong, Chengjie; Benzinger, Tammie; Masters, Colin L.; Laske, Christoph; Jucker, Mathias; Lopera, Francisco; Gordon, Brian A.; Llibre-Guerra, Jorge; Levin, Johannes; Huey, Edward D.; Hassenstab, Jason; Schofield, Peter R.; Day, Gregory S.; Fox, Nick C.; Chhatwal, Jasmeer; Ibanez, Laura; Roh, Jee Hoon; Perrin, Richard; Lee, Jae-Hong; Allegri, Ricardo Francisco; Supnet-Bell, Charlene; Berman, Sarah B.; Daniels, Alisha; Noble, James; Martins, Ralph N.; Rainey-Smith, Stephanie; Peiffer, Jeremiah; Gardener, Samantha L.; Bateman, Randall J.; Morris, John C.; McDade, Eric; Erickson, Kirk I.; Sohrabi, Hamid R.; Brown, Belinda M.; Dominantly Inherited Alzheimer's Network (Wiley, 2024-09-26)

  Introduction: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. Methods: Participants ...
• Population attributable fractions for risk factors for dementia in seven Latin American countries: an analysis using cross-sectional survey data 

  Paradela, Regina Silva; Calandri, Ismael Luis; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; Crivelli, Lucìa; Yaffe, Kristine; Cleusa P Ferri, Cleusa P.; Mukadam, Naaheed; Livingston, Gill; Suemoto, Claudia Kimie (Elsevier, 2024-10)

  Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine ...
• Chapter 2 - Novel imaging approaches in multiple sclerosis. 

  Farez, Mauricio Franco (Elsevier, 2024)

  In recent years, there has been significant advancement in the utilization of magnetic resonance imaging (MRI) for the diagnostic evaluation of patients with multiple sclerosis (pwMS). The 2017 McDonald criteria have ...
• Differential diagnosis of suspected multiple sclerosis: global health considerations 

  Correale, Jorge; Solomon, Andrew J.; Cohen, Jeffrey A.; Banwell, Brenda L.; Gracia, Fernando; Gyang, Tirisham V.; Diaz de Bedoya, Fernando Hamuy; Harnegie, Mary P.; Hemmer, Bernhard; Jacob, Anu; Kim, Ho Jin; Marrie, Ruth Ann; Matee, Farrah J.; Newsome, Scott D.; Pandit, Lekha; Prayoonwiwat, Naraporn; Sahraian, Mohammad A.; Sato, Douglas K.; Saylor, Deanna; Shi, Fu-Dong; Siva, Aksel; Tan, Kevin; Viswanathan, Shanthi; Wattjes, Mike P.; Weinshenker, Brian; Yamout, Bassem; Fujihara, Kazuo (Lancet Pub. Group, 2024-10)

  The differential diagnosis of multiple sclerosis can present specific challenges in patients from Latin America, Africa, the Middle East, eastern Europe, southeast Asia, and the Western Pacific. In these areas, environmental ...
• Chapter 3 - Effect of infections on multiple sclerosis 

  Correale, Jorge; Marrodán, Mariano (Elsevier, 2024)

  Evidence from both epidemiological and experimental studies, implicate infections present during childhood and young adulthood to the development and/or exacerbation of MS. Possible infectious agents include Epstein–Barr ...
• The Risk of Multiple Sclerosis Relapse After Vaccination: Can a Population-Based Study of Mass Vaccination End the Longstanding Debate? 

  Abboud, Hesham; Farez, Mauricio Franco (Lippincott Williams & Wilkins, 2024-08-10)
• Strategies to Advance Stroke Care in Women: An International Conversation. 

  Khedr, Eman M.; Al-Attar, Ghada; Rosales, Julieta Soledad; Sampaio Silva, Gisele; Sebastian, Ivy Anne; Orjuela, Karen D.; de Souza, Ana Cláudia (Lippincott Williams & Wilkins, 2024-08-22)
• Relevance of genetic testing in the gene-targeted trial era: the Rostock Parkinson's disease study 

  Westenberger, Ana; Skrahina, Volha; Usnich, Tatiana; Beetz, Christian; Vollstedt, Eva-Juliane; Laab, Björn-Hergen; Paul, Jefri J.; Curado, Filipa; Skobalj, Snezana; Gaber, Hanaa; Olmedillas, María; Bogdanovic, Xenia; Ameziane, Najim; Schell, Nathalie; Aasly, Jan Olav; Afshari, Mitra; Agarwal, Pinky; Aldred, Jason; Alonso Frech, Fernando; Anderson, Roderick; Merello, Marcelo (Oxford University Press, 2024-08-01)

  Estimates of the spectrum and frequency of pathogenic variants in Parkinson's disease (PD) in different populations are currently limited and biased. Furthermore, although therapeutic modification of several genetic targets ...
• Telomere length as a biomarker in multiple sclerosis 

  Piedrabuena, María Agustina; Correale, Jorge; Farez, Mauricio Franco; Rodríguez Murúa, Sofía; Martínez Canyazo, Carlos; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (SAGE Publications, 2024-09-09)

  Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS). Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to ...
• Prevalence and Factors Associated with Carotid Stenosis in Acute Ischemic Stroke Patients with Atrial Fibrillation 

  Sagris, Dimitrios; Korompoki, Eleni; Strambo, Davide; Mavraganis, Georgios; Michel, Patrik; Eskandari, Ashraf; Vemmos, Konstantinos; Lastras, Clara; Rodriguez Pardo, Jorge; Fuentes, Blanca; Díez Tejedor, Exuperio; Tiili, Paula; Lehto, Mika; Putaala, Jukka; Cuadrado Godia, Elisa; Farington Terrero, Esmirna; Arauz, Antonio; Kamel, Hooman; Rosales, Julieta Soledad; Rodríguez Pérez, María Soledad; Gómez Schneider, Maia; Barboza, Miguel; Tsiskaridze, Alexander; Ntaios, George (Karger, 2024-07-09)

  Introduction: Among stroke patients with atrial fibrillation (AF), it is not uncommon to identify carotid atherosclerosis. This study aimed to estimate the prevalence of, and factors associated with, carotid atherosclerosis ...
• Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis 

  Mosquera Heredia, Maria I.; Vidal, Oscar M.; Morales, Luis C.; Silvera Redondo, Carlos; Barceló, Ernesto; Allegri, Ricardo Francisco; Arcos Burgos, Mauricio; Vélez, Jorge I.; Garavito Galofre, Pilar (MDPI, 2024-07-11)

  Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied ...
• Epidemiology of Huntington's Disease in Latin America: A Systematic Review and Meta-Analysis 

  Medina Escobar, Alex; Pringsheim, Tamara; Gautreau, Sylvia; Rivera Duarte, Jose D.; Amorelli, Gabriel; Cornejo Olivas, Mario; Rossi, Malco (Wiley-Liss, 2024-07-23)

  Background: Latin America has played a crucial role in advancing our understanding of Huntington's disease (HD). However, previous global reviews include limited data from Latin America. It is possible that English-based ...
• Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation 

  Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco (Elsevier, 2024-09)

  We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem ...
• Availability and barriers to access post-stroke rehabilitation in Latin America 

  González Aquines, Alejandro; Rosales, Julieta; De Souza, Ana Claudia; Corredor Quintero, Ángel; Barboza, Miguel A.; Navia González, Víctor; Brunet Pérez, Florencia; Lagos Servellon, Javier; Novarro Escudero, Nelson; Ortega Moreno, Diego A.; Villarroel Saavedra, Víctor; Abanto, Carlos; Barrientos Guerra, José Domingo; Saltos Mata, Filadelfo; Papavasileiou, Vasileios; Todd, Oliver; Góngora Rivera, Fernando; ALATAC collaborators (Saunders, 2024-08-05)

  Objectives: To describe the availability and barriers to access post-stroke rehabilitation services in Latin America. Materials and methods: We conducted a multi-national survey in Latin American countries. The survey ...
• Perspectives on brain health and dementia prevention in Latin America: challenges and opportunities 

  Fox, Sarah; León, Tomás; Mariano, Luciano; Arshad, Faheem; Magrath Guimet, Nahuel; Hope, Grainne; Tituaña, Kuripacha; Zapata Restrepo, Lina María (Frontiers Media SA, 2023-10-16)

  While age-specific dementia prevalence is falling in many countries, several recent reviews estimate prevalence in Latin America to be higher than anywhere else in the world. This may be, in part, due to the high incidence ...
• Traditional first-line treatment failure rates in neuromyelitis optica spectrum disorder patients included in the Argentinean registry (RelevarEM) 

  Carnero Contentti, Edgar; Lopez, Pablo A.; Patrucco, Liliana; Cristiano, Edgardo; Miguez, Jimena; Silva, Berenice; Liwacki, Susana; Tkachuk, Verónica; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Leguizamon, Felisa; Luetic, Geraldine; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Burgos, Marcos; Hryb, Javier; Barboza, Andrés; Lazaro, Luciana; Alonso, Ricardo; Fernández Liguori, Nora; Nadur, Débora; Martínez, Alejandra; Steinberg, Judith; Carrá, Adriana; Alonso Serena, Marina; Rojas, Juan I. (Elsevier, 2024-09)

  Background: Immunosuppressive therapies as azathioprine (AZA), mycophenolate mofetil (MMF) and rituximab (RTX) are widely prescribed as first-line treatment to prevent relapses in NMOSD. However, the rate of response to ...
• International Headache Society global practice recommendations for the acute pharmacological treatment of migraine 

  Puledda, Francesca; Sacco, Simona; Diener, Hans-Christoph; Ashina, Messoud; Al-Khazali, Haidar M.; Ashina, Sait; Burstein, Rami; Liebler, Eric; Cipriani, Andrea; Chu, Min Kyung; Cocores, Alexandra; Dodd-Glover, Freda; Ekizoğlu, Esme; Garcìa Azorìn, David; Göbel, Carl; Goicochea, María Teresa; Hassan, Amr; Hirata, Koichi; Hoffmann, Jan; Jenkins, Bronwyn; Kamm, Katharina; Lee, Mi Ji; Ling, Yu-Hsiang; Lisicki, Marco; Martinelli, Daniele; Monteith, Teshamae S.; Ornello, Raffaele; Ozge, Aynur; Peres, Mario; Pozo Rosich, Patricia; Romanenko, Volodymyr; Schwedt, Todd J.; Souza, Marcio Nattan P.; Takizawa, Tsubasa; Terwindt, Gisela M.; Thuraiaiyah, Janu; Togha, Mansoureh; Vandenbussche, Nicolas; Wang, Shuu-Jiun; Yu, Shengyuan; Tassorelli, Cristina (Sage, 2024-08)

  Background: In an effort to improve migraine management around the world, the International Headache Society (IHS) has here developed a list of practical recommendations for the acute pharmacological treatment of migraine. ...
• Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina 

  Calandri, Ismael Luis; Livingston, Gill; Paradela, Regina; Ossenkoppele, Rik; Crivelli, Lucía; Allegri, Ricardo Francisco; Suemoto, Claudia K. (Karger, 2024-01-31)

  Introduction: Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such factors in middle- and low-income countries. We aimed to estimate the population-attributable ...
• Early dual antiplatelet therapy in patients with minor ischemic stroke after intravenous thrombolysis 

  Alet, Matías Javier; Balcarce, Pilar; Ameriso, Sebastián Francisco (Saunders, 2024-07-29)

  Objectives: Minor stroke is defined by a score of 5 or less on the National Institutes of Health Stroke Scale (NIHSS). Prior trials have shown efficacy of short term dual antiplatelet therapy (DAPT) in secondary prevention ...

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