• Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 

  Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)

  We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...
• IAPRD new consensus classification of myoclonus 

  Latorre, Anna; van der Veen, S.; Pena, Ashley; Truong, Daniel; Erro, Roberto; Frucht, Steven; Ganos, Christos; Hallett, Mark; Perez-Duenas, Belen; Rossi, Malco Damián; Roze, Emmanuel; Vidailhet, Marie; Aj de Koning-Tijssen, Marina; Caviness, John N. (Elsevier, 2025-02-20)

  Introduction: Recent new advances in myoclonus characterization and etiology justify an update of the 40-year-old respected classification of myoclonus proposed by Marsden, Hallett, and Fahn. New advances include genetic ...
• Experts envision a valuable role for tau-PET in clinical practiceand drug trials 

  Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley, 2024)

  Background: Recent advancements in Alzheimer’s disease (AD) biomarker researchand AD drug trials prompt reflection on the value and appropriate use of tau-PET infuture clinical practice and trials. We therefore conducted ...
• Development of a Multidomain Composite InterventionEngagement Score in the U.S. POINTER Trial 

  Ghadimi Nouran, Mina; Katula, Jeffrey A.; Ventrelle, Jennifer; Graef, Sarah; Garcia, Katelyn R.; Lovato, Laura; Wilmoth, Sharon; Woolard, Nancy; Leng, Xiaoyan; Calandri, Ismael Luis; Snyder, Heather M.; Bake, Laura D. (Wiley, 2024)

  Background Multidomain lifestyle interventions have shown promise to slow cognitive decline and possibly prevent dementia. However, challenges arise in analyzing and interpreting treatment response when participants vary ...
• Multi-Component and Cognitive Skills Training in MildCognitive Impairment: Outcomes from a South American Study 

  Martín, María Eugenia; Martínez, Carlos; Worff, Iris; Belucci, María Agustina; Keller, Greta; Arruabarrena, Micaela María; Corvalàn, Nicolás; Clarens, María Florencia; Allegri, Ricardo Francisco; Crivelli, Lucía (Wiley, 2024)

  Background: Dementia represents a significant health challenge, with evidencesuggesting that it can be potentially delayed or prevented through non-pharmacological interventions. There are different types of non-pharmaco ...
• Is FDG-PET metabolism associated with cognitive performancein long-Covid patients? 

  Hernández, Micaela Anahí; Santos Machado, Luiza; De Bastiani, Marco; Hugentobler Schlickmann, Thomas; Ferrari-Souza, João Pedro; Carello, Agostina; Helou, Belén; Crivelli, Lucía; Osa Sanz, Emilia; Bérgamo, Yanina; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; Zimmer, Eduardo R.; Calandri, Ismael Luis (Wiley, 2024)

  Background: Current evidence indicates that COVID-19 infection can lead toneurological complications that persist beyond 12 weeks of infection (long-COVID),often associated with cognitive decline. However, the underlying ...
• Multi-modal AI screening for MCI and Alzheimer's Disease: results from an Argentine Cohort 

  Belloli, Laouen; Keller, Greta; Carello, Agostina; Gauder, Lara; Juantorena, Gustavo; Corvalan, Nicolás; Allegri, Ricardo Francisco; Crivelli, Lucía; Fernández Slezak, Diego (Wiley, 2024)

  Early detection of Mild Cognitive Impairment (MCI) is crucial for effective prevention. Traditional methods like expert judgment, clinical evaluations, and manual linguistic analyses are now complemented by Artificial ...
• Tic Disorders Care Gaps in Spanish-Speaking Latin America 

  Medina Escobar, Alex; Munoz, Daniela; Gautreau, Sylvia; Rossi, Malco Damián; Pringsheim, Tamara (Wiley, 2025-02-22)

  Background: Primary tic disorders (TD) are common movement disorders in childhood. However, it is unclear if international guidelines are applied in Latin America. Objectives: To investigate the applicability of TD ...
• Mortalidad intrahospitalaria por accidente cerebrovascular en un centro urbano en Argentina 

  Echarri, María Martina; Rodríguez Lucci, Federico; Pujol Lereis, Virginia Andrea; Finkelsztein, Marina Y.; González, Claudio D.; Ameriso, Sebastián Francisco (Fundación Revista Medicina, 2025-03)

  Introducción: La mortalidad intrahospitalaria es influenciada por diversos factores. A pesar de la tendencia a la disminución de la mortalidad por accidente cerebrovascular (ACV) agudo en el hemisferio norte, los informes ...
• Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America 

  Cubas Guillen, Jonathan Fernando; Ardohain, Carolina; Berrios, Waleska; Deschle, Florencia; Dorman, Guido; Fernandez Boccazzi, Julian; Flores, Ignacio; Graviotto, Héctor Gastón; Isaac, Cristian Flavio; Rojas, Galeno; Román, Karen Daniela; Scribano Parada, Maria de la Paz; Sorbara, Marcos; Allegri, Ricardo Francisco; Calandri, Ismael Luis (IOS Press, 2025-01-31)

  Background: Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases. Objective: The ...
• Brain metabolic subtypes in Long Covid individuals from a Brazilian cohort 

  Viana Jotz, Arthur; De Bastiani, Marco; Santos Machado, Luiza; Hugentobler Schlickmann, Thomas; Silveira, Maiele Dornelles; Senger, Joana Emilia; Vendramini Borelli, Wyllians; Ferrari‐Souza, João Pedro; Povala, Guilherme; Bornes da Silva, Ana Paula; Uglione da Ros, João Pedro; Bastos de Mello, Guilherme; Fakhri Kadan, Matheus; Radaelli, Graciane; de Paula de Paula Faria, Daniele; Martins Coutinho, Artur; Lourenco, Mychael V.; Hernández, Micaela Anahí; Calandri, Ismael Luis; Pascoal, Tharick A.; Matushita, Cristina Sebastião; Benardi Soder, Ricardo; Schumacher‐Schuh, Artur Francisco; Souza, Diogo O.; Costa da Costa, Jaderson; Guerini de Souza, Débora; Zimmer, Eduardo R. (John Wiley & Sons, 2024)

  Background: The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is one of the biggest health concerns of the century. Long COVID is one of the major sequelae from the infection and include persistent neurological ...
• Long-term follow-up of patients with a first clinical demyelinating event (clinically isolated syndrome) who received cladribine tablets in CLASSIC-MS: Findings for the ORACLE-MS cohort 

  Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; di Cantogno, Elisabetta Verdun (SAGE, 2024-12-17)

  Background: CLASSIC-MS explored long-term outcomes of patients treated with cladribine tablets. Objective: Assess long-term efficacy in patients previously enrolled in ORACLE-MS, a Phase III parent trial. Methods: ...
• Frailty and Implications for Multiple Sclerosis Management 

  Correale, Jorge (American Medical Association, 2025-03-03)

  This Viewpoint discusses the unique needs of patients with multiple sclerosis and frailty and describes the gaps that should be addressed in frailty measurement and clinical management.
• Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations 

  Farina, Francesca R.; Bridgeman, Katie; Gregory, Sarah; Crivelli, Lucía; Foote, Isabelle F.; Jutila, Otto-Emil I.; Kucikova, Ludmila; Mariano, Luciano I.; Nguyen, Kim-Huong; Thayanandan, Tony; Akindejoye, Funmi; Butler, Joe; Calandri, Ismael Luis; Čepukaitytė, Giedrė; Chiesa, Scott T.; Dawson, Walter D.; Deckers, Kay; De la Cruz-Góngora, Vanessa; Dounavi, Maria-Eleni; Govia, Ishtar (Elsevier, 2024-12-20)

  fforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a ...
• Emerging immune tolerance therapies for neuromyelitis optica spectrum disorder 

  Carnero Contentti, Edgar; Correale, Jorge (Taylor & Francis, 2025-02-23)

  Resumen no disponible
• Cost evaluation of acute ischemic stroke in Latin America: a multicentric study 

  Dittrich, Luiza Borba; da Silva Etges, Ana Paula Beck; Siqueira de Souza, Joana; Zago Marcolino, Miriam Allein; Rocha, Eva; Amaya, Pablo; Barboza, Miguel A.; Saavedra, Andrés Gaye; Pérez Hornos, Gonzalo; Abanto, Carlos; Castillo-Soto, Ana Lucía; Llanos-Leyton, Natalia; Pujol Lereis, Virginia Andrea; Rodriguez Pérez, María Soledad; Alet, Matías Javier; Navia, Victor; Lopez, Solange; Arauz, Antonio; Serrano, Fabiola; Chwal, Bruna; Carbonera, Leonardo Augusto; Gomes Nogueira, Raul; Saposnik, Gustavo; Polanczyk, Carisi Anne; Ouriques Martins, Sheila Cristina; de Souza, Ana Cláudia (Elsevier, 2024-12-06)

  Background: Current literature highlights a gap in precise stroke cost data for Latin America. This study measures the real costs associated with acute ischemic stroke care in Latin America using Time-Driven Activity-Based ...
• Risk factors and baseline cognition. Preliminary results from the LatAm-FINGERS cohort 

  Corvalán, Nicolás; Keller, Greta; Surace, Ezequiel Ignacio; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Monica; Allegri, Ricardo Francisco; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Sevlever, Gustavo Emilio; Crivelli, Lucía; LatAm-FINGERS Consortium (Wiley, 2024)

  Background LatAm-FINGERS - the first non-pharmacological multicenter randomized clinical trial in Latin America - is a valuable opportunity to study lifestyle in a heterogeneous and multiethnic population exposed to a ...
• Live-attenuated vaccines for multiple sclerosis patients living in regions with endemic infections: A complex decision 

  Correale, Jorge; Marrodan, Mariano (Sage, 2024-12-18)

  Live-attenuated vaccines provide robust immunity against diseases like tuberculosis, measles, mumps, rubella, polio, yellow fever, dengue, typhoid fever, and varicella, with just one or a few doses. However, concerns arise ...
• Chapter 10 - Autoimmune Astrocytopathy 

  Correale, Jorge (Springer Nature, 2024)

  Astrocytes constitute the most abundant type of glial cells in the central nervous system (CNS) and display significant heterogeneity. Astrocytes actively engage in various metabolic processes and are active contributors ...
• Case report: A 50 year-old Down syndrome man exhibiting noAlzheimer’s disease biomarker profile nor cognitiveimpairment. Experience from the Argentine Initiative for theStudy of Down syndrome and Alzheimer’s 

  Clas, Giulia Solange; Pertierr, Lucía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda, Fernanda; Magrath Guimet, Nahuel; Allegri, Ricardo Francisco; Marazita, Mariela; Romorini, Leonardo; Surace, Ezequiel Ignacio (Wiley, 2024)

  Background: Down Syndrome (DS) is the most common genetic form of intellectualdisability. In recent years, there has been a significant increase in the life expectancyof individuals with DS, currently reaching the age of ...

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