• Long-term Effect of Ofatumumab on Serum Immunoglobulin Levels in Patients with Relapsing Multiple Sclerosis (P9-6.007) 

  Bar-Or, Amit; Wiendl, Heinz; De Seze, Jerome; Correale, Jorge; Cross, Anne; Derfuss, Tobias; Selmaj, Krzysztof; Winthrop, Kevin; Giacomini, Paul; Sacca, Francesco; Hu, Xixi; Sullivan, Roseanne; Jehl, Valentine; Boer, Ibolya; Bhatt, Alit; Hauser, Stephen (American Academy of Neurology, 2024-03-09)
• Core data set for real world data in multiple sclerosis: customization for latin america from a global task force recommendation. 

  Rojas, J.I.; Gracía, F.; Parciak, T.; Alonso, R.; Becker, J.; Treviño Frenk, I.; Alonso Serena, M.; Giunta, D.; Abad, P.; Carnero Contentti, Edgar; Carrá, A.; Correa Díaz, E.P.; Correale, Jorge; Cristiano, E.; Flores, J.; Fruns, M.; Galleguillos, L.; Garcea, O.; Hamuy, F.; Lana Peixoto, M.; Navas, C.; Pappais Alvarenga, R.; Patrucco, L.; Rivera, V.; Tenembaum, S.; Ysrraelit, María Célica; Peeters, L.M. (Viguera, 2024-04-01)

  Introduction: The primary objective of the core data set is to reduce heterogeneity and promote harmonization among data sources in EM, thereby reducing the time needed to execute real life data collection efforts. Recently, ...
• Comorbidities in multiple sclerosis and their influence on the choice of treatment 

  Barboza, Andrés G.; Sinay, Vladimiro; Alonso, Ricardo; Carnero Contentti, Edgar; Hryb, Javier; Silva, Berenice Anabel; Tavolini, Darío; Ysrraelit, María Célica; Correale, Jorge (Revista de Neurología, 2024-03-16)

  Los estudios clínicos de tratamientos para personas con esclerosis múltiple (pEM) se realizan en poblaciones seleccionadas, que excluyen a pacientes que presenten comorbilidades o medicaciones concomitantes. Sin embargo, ...
• Remyelinating effect driven by transferrin-loaded extracellular vesicles 

  Mattera, Vanesa S.; Occhiuzzi, Federico; Correale, Jorge; Pasquini, Juana María (Wiley, 2023-10-20)

  Extracellular vesicles (EVs) are involved in diverse cellular functions, playing a significant role in cell-to-cell communication in both physiological conditions and pathological scenarios. Therefore, EVs represent a ...
• Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry 

  Carnero Contentti, Edgar; López, Pablo A.; Pettinicchi, Juan Pablo; Criniti, Juan; Pappolla, Agustín; Miguez, Jimena; Cristiano, Edgardo; Patrucco, Liliana; Liwacki, Susana; Tkachuk, Verónica; Balbuena, María E.; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine; Menichini, María L.; Tavolini, Darío (Sage, 2023-10-17)

  We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) ...
• A plain language summary on assessing the long-term effectiveness of cladribine tablets in people living with relapsing multiple sclerosis: The CLASSIC-MS study 

  Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; Verdun di Cantogno, Elisabetta (Future Medicine, 2023-08-03)

  What is this summary about?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 ...
• Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes 

  Wies Mancini, Victoria Sofía Berenice; Mattera, Vanesa S.; Pasquini, Juana María; Pasquini, Laura Andrea; Correale, Jorge (Wiley on behalf of the International Society for Neurochemistry, 2023-12-06)

  Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively ...
• Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina 

  Carnero Contentti, Edgar; López, Pablo A.; Pappolla, Agustín; Alonso, Ricardo; Silva, Berenice Anabel; Deri, Norma; Balbuena Aguirre, María Eugenia; Burgos, Marcos; Luetic, Geraldine G.; Alvez Pinheiro, Amelia; Cabrera, Mariela; Hryb, Javier; Nofal, Pedro; Pestchanker, Claudia; Vrech, Carlos; Tavolini, Darío; Marrodan, Mariano; Ysrraelit, María Célica; Correale, Jorge; on behalf RelevarEM (Springer-Verlag Italia, 2023-12-30)

  We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina ...
• Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease 

  Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack Jr, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network and the Alzheimer’s Disease Neuroimaging Initiative (American Medical Association, 2023-12-01)

  Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains ...
• Clinical characterization of long-term multiple sclerosis (COLuMbus) patients in Argentina: A cross-sectional non-interventional study 

  Deri, Norma; Barboza, Andrés G.; Vrech, Carlos; Rey, Roberto; Burgos, Marcos; Fiol, Marcela Paula; Calvo Vildoso, Christian; Patrucco, Liliana; José, Gustavo; Aliberti, Paula; Chirico, Daniela; Federico, María B.; Seifer, Gustavo; Piedrabuena, Raúl (Elsevier, 2023-12-31)

  Background: Most Multiple Sclerosis (MS) clinical trials fail to assess the long-term effects of disease-modifying therapies (DMT) or disability. Methods: COLuMbus was a single-visit, cross-sectional study in Argentina ...
• Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting 

  Carnero Contentti, Edgar; Lopez, Pablo A.; Tkachuk, Verónica; Vrech, Carlos; Zarate, María A.; Correale, Jorge; Deri, Norma; Luetic, Geraldine; Marrodán, Mariano; Pagani Cassara, Fátima; Tavolini, Darío; Ysrraelit, María Célica; Balbuena, María E.; Hryb, Javier; Chiganer, Edson; Leguizamon, Felisa; Knorre, Eduardo; Zanga, Gisela; Pestchanker, Claudia; Barboza, Andrés (Sage, 2023-07-25)

  Background: We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis ...
• Differential diagnosis of suspected multiple sclerosis: an updated consensus approach 

  Solomon, Andrew J.; Arrambide, Georgina; Brownlee, Wallace J.; Flanagan, Eoin P.; Amato, Maria Pia; Amezcua, Lilyana; Banwell, Brenda L.; Barkhof, Frederik; Corboy, John R.; Correale, Jorge; Fujihara, Kazuo; Graves, Jennifer; Harnegie, Mary Pat; Hemmer, Bernhard; Lechner-Scott, Jeannette; Marrie, Ruth Ann; Newsome, Scott D.; Rocca, Maria A.; Royal, Walter; Waubant, Emmanuelle L. (Lancet, 2023-07-19)

  Accurate diagnosis of multiple sclerosis requires careful attention to its differential diagnosis-many disorders can mimic the clinical manifestations and paraclinical findings of this disease. A collaborative effort, ...
• Global Barriers to the Diagnosis of Multiple Sclerosis: Data From the Multiple Sclerosis International Federation Atlas of MS, Third Edition 

  Solomon, Andrew J.; Marrie, Ruth Ann; Viswanathan, Shanthi; Correale, Jorge; Magyari, Melinda; Robertson, Neil P.; Saylor, Deanna R.; Kaye, Wendy; Rechtman, Lindsay; Bae, Eunchan; Shinohara, Russell; King, Rachel; Laurson-Doube, Joanna; Helme, Anne (Lippincott Williams & Wilkins, 2023-06-15)

  Background and objectives: Recent data suggest increasing global prevalence of multiple sclerosis (MS). Early diagnosis of MS reduces the burden of disability-adjusted life years and associated health care costs. Yet ...
• Latin American consensus recommendations on the risk of infections in people with multiple sclerosis treated with disease modifying drugs 

  Silva, Berenice A.; Carnero Contentti, Edgar; Becker, Jefferson; Carranza, José I.; Correa-Díaz, Patricio E.; Galleguillos Goiry, Lorna; Garcea, Orlando; Gracia, Fernando; Hamuy, Fernando; Macías, Miguel Angel; Navas, Carlos; Nuñez, Sebastián; Rojas, Juan Ignacio; Farez, Mauricio Franco; Alonso, Ricardo; López, Pablo (Elsevier, 2023-06-20)

  Introduction: The emergence of several therapeutic options in multiple sclerosis (MS), which significantly modify the immune system functioning, has led to the need for the consideration of additional factors, such as risk ...
• Serological response to SARS-CoV-2 vaccines in patients with multiple sclerosis in Argentina 

  Rojas, Juan Ignacio; Alonso, Ricardo; Cabrera, Mariela; Carnero Contentti, Edgar; Cristiano, Edgardo; Deri, Norma; Hryb, Javier; Lopez, Pablo; Luetic, Geraldine; Patrucco, Liliana; Tkachuk, Veronica; Ysrraelit, María Célica; Zanga, Gisela; Cruces, Leonel; Turk, Gabriela; Longueira, Yesica; Laufer, Natalia; Nuñez, Sebastián (Fundación Revista Medicina, 2023-03-02)

  Introduction: The objective was to assess the immunogenicity and effectiveness of vaccines against SARSCoV-2 in multiple sclerosis (MS) patients included in the Argentinean MS registry. Methods: A prospective cohort ...
• Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome 

  Plantone, Domenico; Sabatelli, Eleonora; Locci, Sara; Marrodán, Mariano; Laakso, Sini M.; Mateen, Farrah J.; Feresiadou, Amalia; Buelens, Tom; Bianco, Assunta; Fiol, Marcela Paula; Correale, Jorge; Tienari, Pentti; Calabresi, Paolo; De Stefano, Nicola; Iorio, Raffaele (Wiley, 2023-06-19)

  Background and purpose: Serum levels of neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising neuro-axonal damage and astrocytic activation biomarkers. Susac syndrome (SS) is an ...
• Clinical characteristics, course and prognosis of Multiple Sclerosis patients with epilepsy. A case control study: MS and epilepsy 

  Sánchez, M.; Marone, Abril; Silva, Walter H.; Marrodán, Mariano; Correale, Jorge (Elsevier, 2024-01-02)

  Background and purpose: Although more common than in the general population, seizures are an atypical manifestation of multiple sclerosis (MS) and their pathophysiology is not well understood. This study aims to examine ...
• Clinical impact of gender and age at onset on disease trajectory in primary progressive multiple sclerosis patients 

  Camerlingo, Sebastián; Rubinstein, Fernando; Ysrraelit, María Célica; Correale, Jorge; Carnero Contentti, Edgar; Rojas, Juan Ignacio; Patrucco, Liliana; Del Valle Leguizamon, Felisa; Tkachuk, Verónica A.; Fernández Liguori, Nora; Cristiano, Edgardo; Mainella, Carolina; Zanga, Gisela; Carrá, Adriana; Marrodán, Mariano; Martínez, Alejandra Diana; Silva, Berenice Anabel; Alonso, Ricardo (Sage Publications, 2024-01-21)

  Background and objectives: Primary-progressive multiple sclerosis (PPMS) is characterized by gradual neurological deterioration without relapses. This study aimed to investigate the clinical impact of gender and age at ...
• European Committee for Treatment and Research in Multiple Sclerosis and European Academy of Neurology consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs 

  Otero-Romero, Susana; Lebrun-Frenay, Christine; Reyes, Saúl; Amato, María Pía; Campins, Magda; Farez, Mauricio Franco; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Magyari, Melinda; Oreja-Guevara, Celia; Siva, Aksel; Vukusic, Sandra; Tintoré, Mar (Wiley, 2023-06-09)

  Background and purpose With the new highly active drugs available for people with multiple sclerosis (pwMS), vaccination becomes an essential part of the risk management strategy. We aimed to develop a European evidence-based ...
• ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs 

  Otero-Romero, Susana; Lebrun-Frenay, Christine; Reyes, Saúl; Amato, María Pía; Campins, Magda; Farez, Mauricio Franco; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Magyari, Melinda; Oreja-Guevara, Celia; Siva, Aksel; Vukusic, Sandra; Tintoré, Mar (Sage, 2023-06-09)

  Background: With the new highly active drugs available for people with multiple sclerosis (pwMS), vaccination becomes an essential part of the risk management strategy. Objective: To develop a European evidence-based ...

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