• Long-term follow-up of patients with a first clinical demyelinating event (clinically isolated syndrome) who received cladribine tablets in CLASSIC-MS: Findings for the ORACLE-MS cohort 

  Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; di Cantogno, Elisabetta Verdun (SAGE, 2024-12-17)

  Background: CLASSIC-MS explored long-term outcomes of patients treated with cladribine tablets. Objective: Assess long-term efficacy in patients previously enrolled in ORACLE-MS, a Phase III parent trial. Methods: ...
• Frailty and Implications for Multiple Sclerosis Management 

  Correale, Jorge (American Medical Association, 2025-03-03)

  This Viewpoint discusses the unique needs of patients with multiple sclerosis and frailty and describes the gaps that should be addressed in frailty measurement and clinical management.
• Emerging immune tolerance therapies for neuromyelitis optica spectrum disorder 

  Carnero Contentti, Edgar; Correale, Jorge (Taylor & Francis, 2025-02-23)

  Resumen no disponible
• Live-attenuated vaccines for multiple sclerosis patients living in regions with endemic infections: A complex decision 

  Correale, Jorge; Marrodan, Mariano (Sage, 2024-12-18)

  Live-attenuated vaccines provide robust immunity against diseases like tuberculosis, measles, mumps, rubella, polio, yellow fever, dengue, typhoid fever, and varicella, with just one or a few doses. However, concerns arise ...
• Chapter 10 - Autoimmune Astrocytopathy 

  Correale, Jorge (Springer Nature, 2024)

  Astrocytes constitute the most abundant type of glial cells in the central nervous system (CNS) and display significant heterogeneity. Astrocytes actively engage in various metabolic processes and are active contributors ...
• Additional Cladribine tablets treatment courses in multiple sclerosis patients. A retrospective observational study in Latin American countries 

  Silva, Berenice Anabel; Ysrraelit, María Célica; Zanga, Gisela; Segamarchi, María Constanza; Cragnolini, Carolina; Galleguillos, Lorna; Halfon, Mario Javier; Miguez, Jimena; Parada Marcilla, Marcela; Pereyra, Adriana; Silva, Emanuel; Vrech, Carlos; D'Eramo, Mariana; Negrotto, Laura (Elsevier, 2025-01-14)

  The use of additional cladribine tablets treatment courses is becoming an option in patients with multiple sclerosis (MS) showing disease activity after treatment initiation. Despite the availability over the past year of ...
• Performance of treatment response scoring systems among patients with multiple sclerosis treated with high-efficacy therapies 

  Marrodán, Mariano; Sao Avilés, Augusto; Río, Jordi; Cobo-Calvo, Álvaro; Fernández, Victoria; Pappolla, Agustin; Castilló, Joaquín; Vidal-Jordana, Ángela; Arrambide, Georgina; Tur, Carmen; Rodríguez-Acevedo, Breogán; Zabalza, Ana; Mongay-Ochoa, Neus; Vilaseca, Andreu; Rodriguez, Marta; Galán, Ingrid; Comabella, Manuel; Sastre-Garriga, Jaume; Tintoré, Mar; Auger, Cristina (Sage, 2025-02-10)

  Background: Predicting treatment response and disease progression in multiple sclerosis (MS) is challenging. Treatment Response Scoring Systems (TRSS) are potentially useful, but their utility in patients receiving ...
• Eculizumab or ravulizumab treatment effect in people with neuromyelitis optica spectrum disorder: a plain language summary of three studies 

  Damasceno, Alfredo; Marrodán, Mariano (Future Medicine, 2025-02-12)

  What is this summary about?: Neuromyelitis optica spectrum disorder (NMOSD for short) is a rare autoimmune health condition, meaning that the body's natural defense system (the immune system) attacks the body's own tissues. ...
• New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis 

  Carrera Silva, Eugenio Antonio; Correale, Jorge; Rothlin, Carla V.; Ortiz Wilczyñski, Juan Manuel (American Society for Pharmacology and Experimental Therapeutics, 2024-10-08)

  Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based ...
• Chapter 2 - Novel imaging approaches in multiple sclerosis. 

  Farez, Mauricio Franco (Elsevier, 2024)

  In recent years, there has been significant advancement in the utilization of magnetic resonance imaging (MRI) for the diagnostic evaluation of patients with multiple sclerosis (pwMS). The 2017 McDonald criteria have ...
• Differential diagnosis of suspected multiple sclerosis: global health considerations 

  Correale, Jorge; Solomon, Andrew J.; Cohen, Jeffrey A.; Banwell, Brenda L.; Gracia, Fernando; Gyang, Tirisham V.; Diaz de Bedoya, Fernando Hamuy; Harnegie, Mary Pat; Hemmer, Bernhard; Jacob, Anu; Kim, Ho Jin; Marrie, Ruth Ann; Mateen, Farrah J.; Newsome, Scott D.; Pandit, Lekha; Prayoonwiwat, Naraporn; Sahraian, Mohammad A.; Sato, Douglas K.; Saylor, Deanna R.; Shi, Fu-Dong; Siva, Aksel; Tan, Kevin; Viswanathan, Shanthi; Wattjes, Mike P.; Weinshenker, Brian G.; Yamout, Bassem; Fujihara, Kazuo (Lancet Pub. Group, 2024-10)

  The differential diagnosis of multiple sclerosis can present specific challenges in patients from Latin America, Africa, the Middle East, eastern Europe, southeast Asia, and the Western Pacific. In these areas, environmental ...
• Chapter 3 - Effect of infections on multiple sclerosis 

  Correale, Jorge; Marrodán, Mariano (Elsevier, 2024)

  Evidence from both epidemiological and experimental studies, implicate infections present during childhood and young adulthood to the development and/or exacerbation of MS. Possible infectious agents include Epstein–Barr ...
• The Risk of Multiple Sclerosis Relapse After Vaccination: Can a Population-Based Study of Mass Vaccination End the Longstanding Debate? 

  Abboud, Hesham; Farez, Mauricio Franco (Lippincott Williams & Wilkins, 2024-08-10)
• Telomere length as a biomarker in multiple sclerosis 

  Piedrabuena, María Agustina; Correale, Jorge; Farez, Mauricio Franco; Rodríguez Murúa, Sofía; Martínez Canyazo, Carlos; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (SAGE Publications, 2024-09-09)

  Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS). Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to ...
• Traditional first-line treatment failure rates in neuromyelitis optica spectrum disorder patients included in the Argentinean registry (RelevarEM) 

  Carnero Contentti, Edgar; Lopez, Pablo A.; Patrucco, Liliana; Cristiano, Edgardo; Miguez, Jimena; Silva, Berenice Anabel; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Leguizamon, Felisa; Luetic, Geraldine G.; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Burgos, Marcos; Hryb, Javier Pablo; Barboza, Andrés G.; Lázaro, Luciana; Alonso, Ricardo; Fernández Liguori, Nora; Nadur, Débora; Martínez, Alejandra Diana; Steinberg, Judith; Carrá, Adriana; Alonso Serena, Marina; Rojas, Juan Ignacio (Elsevier, 2024-09)

  Background: Immunosuppressive therapies as azathioprine (AZA), mycophenolate mofetil (MMF) and rituximab (RTX) are widely prescribed as first-line treatment to prevent relapses in NMOSD. However, the rate of response to ...
• Diagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis 

  Marrodán, Mariano; Calandri, Ismael Luis; Bocancea, Diana I.; Ysrraelit, María Célica; Gómez Figueroa, Enrique; Massó Páez, Montserrat; Flores, José; Rojas, Juan Ignacio; Ciampi, Ethel; Ioli, Pablo; Zanga, Gisela; Ardohain, Carolina; Fracaro, María Eugenia; Amaya, Mariela; Tkachuk, Verónica A.; Fernández, Victoria C.; José, Gustavo; Silva, Emanuel; Luetic, Geraldine G.; Carnero Contentti, Edgar; Köhler, Eduardo; Pagani Cassará, Fátima; Morán, Dolores; Seimandi, Carla; Paviolo, Juan P.; D'elio, Brenda; Da Prat, Gustavo; Gatto, Emilia M.; Cristiano, Edgardo; Pujol Lereis, Virginia Andrea; Ameriso, Sebastián Francisco; Fiol, Marcela Paula; Correale, Jorge (Wiley-Liss, 2024-07-26)

  Objective: Susac syndrome (SuS), multiple sclerosis (MS), and primary angiitis of the central nervous system (PACNS) present diagnostic challenges due to overlapping clinical features. We aimed to enhance diagnostic precision ...
• The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact 

  Kalaria, Raj; Maestre, Gladys; Mahinrad, Simin; Acosta, Daisy; Akinyemi, Rufus; Alladi, Suvarna; Allegri, Ricardo Francisco; Arshad, Faheem; Babalola, David Oluwasayo; Baiyewu, Olusegun; Bak, Thomas H.; Bellaj, Tarek; Brodie-Mends, David K.; Carrillo, María C.; Celestin, Kaputu-Kalala-Malu; Damasceno, Albertino; de Silva, Ranil Karunamuni; de Silva, Rohan; Djibuti, Mamuka; Dreyer, Anna Jane (John Wiley & Sons, Ltd., 2024-05-02)

  Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of ...
• Human chorionic gonadotropin regulates cytokine production by lymphocytes from patients with multiple sclerosis 

  Juriol, Lorena; Valeff, Natalín; Dibo, Marcos; Ventimiglia, María Silvia; Correale, Jorge; Jensen, Federico (Elsevier/North-Holland Biomedical Press, 2024-06-12)

  Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults, predominantly females. This was partially attributed to sex differences in ...
• Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study 

  Carnero Contentti, Edgar; Lopez, Pablo A.; Pettinicchi, Juan Pablo; Miguez, Jimena; Patrucco, Liliana; Cristiano, Edgardo; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine G.; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Burgos, Marcos; Hryb, Javier Pablo; Barboza, Andrés G.; Lázaro, Luciana; Alonso, Ricardo; Fernández Liguori, Nora; Nadur, Débora; Alonso Serena, Marina; Caride, Alejandro; Rojas, Juan Ignacio (Elsevier, 2024-07-15)

  We aimed to assess the treatment strategies utilized in patients with neuromyelitis optica spectrum disorder (NMOSD) experiencing relapses, including their frequency, types, and response after 6 months based on the Expanded ...
• Real-World Effectiveness and Safety of Cladribine in Multiple Sclerosis: Longitudinal Data From the Nationwide Registry in Argentina 

  Rojas, Juan Ignacio; Alonso, Ricardo; Luetic, Geraldine G.; Patrucco, Liliana; Casas, Magdalena; Silva, Berenice Anabel; Miguez, Jimena; Deri, Norma; Vrech, Carlos; Liwacki, Susana; Piedrabuena, Raúl; Silva, Emanuel; Tkachuk, Verónica A.; Burgos, Marcos; Tavolini, Darío; Zanga, Gisela; Alvez Pinheiro, Amelia; Hryb, Javier Pablo; Leguizamon, Felisa; Knorre, Eduardo; López, Pablo Adrián; Martínez, Alejandra Diana; Carrá, Adriana; Alonso Serena, Marina; Cristiano, Edgardo; Correale, Jorge; Garcea, Orlando; Fernández Liguori, Nora; Carnero Contentti, Edgar (Lippincott Williams & Wilkins, 2024-05-23)

  Objective: The aim was to evaluate patient profiles, effectiveness and safety of cladribine (CLAD) in patients with relapsing-remitting multiple sclerosis in Argentina. Methods: This was a substudy included in RelevarEM ...

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