• Microbiome-derived metabolites from vitamin B2 and B9 pathways modulate MAIT cells from multiple sclerosis patients 

  Correale, Jorge; Marrodán, Mariano; Piedrabuena, María Agustina; Soman, Karthik; Farez, Mauricio Franco; Baranzini, Sergio E. (SAGE, 2026-06-01)

  Background: Mucosal-associated invariant T (MAIT) cells recognize microbial vitamin B2 and B9 metabolites via MR1 and have been implicated in multiple sclerosis (MS). How patient-specific gut microbiota shape human MAIT-cell ...
• Early use of high-efficacy disease-modifying therapies reduces the risk of progression independent of relapse and MRI activity in patients with relapsing-remitting multiple sclerosis 

  Guarnaschelli, María Flor; Marrodán, Mariano; Sosa, Brian Ezequiel; Perez Arana, Carolina I.; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (SAGE, 2026-04-29)

  Background: Progression independent of relapse and MRI activity (PIRMA) is a major contributor to long-term disability in relapsing-remitting multiple sclerosis (RRMS). In Latin America, limited access to high-efficacy ...
• Plasma levels of an N-terminal tau fragment predict Alzheimer's and neurodegenerative disease biomarkers in autosomal dominant Alzheimer's disease 

  Schultz, Stephanie A.; Rao, Rao; Liu, Lei; Ostaszewski, Beth; Anderson, Amirah K.; Yau, Wai-Ying Wendy; Shirzadi, Zahra; Gordon, Brian A.; Hassenstab, Jason; Morris, John C.; Perrin, Richard J.; Allegri, Ricardo Francisco; Barthélemy, Nicolas R.; Fox, Nick C.; Day, Gregory S.; Jucker, Mathias; Levey, Allan I.; Levin, Johannes; Mori, Hiroshi; Salloway, Stephen (Wiley, 2026-06)

  Introduction: Tau species lacking truncation of the N-terminal region, including plasma N-terminal tau fragment 1 (NT1), have been previously associated with cognitive decline, neurodegeneration, and tau pathology in ...
• Recognition memory in individuals with mild cognitive impairment and Alzheimer's dementia: a systematic review 

  Russo, María Julieta; Bueri, José; Ferrara, Lucía Alba; Labos, Edith; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis, 2026-01-06)

  Background: Episodic memory impairment is a hallmark of Alzheimer's disease (AD) and is already present in its prodromal stage. While recall deficits are well established as predictors of memory performance, the role of ...
• Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome 

  Lim, Timothy Reynold; Suthiphosuwan, Suradech; Gaitán, María Inés; Marrodán, Mariano; Horwath, Elizabeth A.; Guenette, Melanie; Bharatha, Aditya; Sati, Pascal; Absinta, Martina; Correale, Jorge; Shinohara, Russell; Reich, Daniel S.; Oh, Jiwon (American Medical Association, 2026-03)

  Importance: Most people with radiologically isolated syndrome (RIS) have high proportions of white matter lesions (WMLs) demonstrating the central vein sign (ie, central vein sign-positive lesion [CVS+L]) and at least 1 ...
• Glial Plasticity and Dysfunction: Mechanistic Insights and Therapeutic Opportunities in Neurodegeneration 

  Correale, Jorge (Wiley, 2026-04)

  Recent advances, including single-cell transcriptomics, lineage tracing, and in vivo imaging, have unveiled the heterogeneity, plasticity, and functional versatility of astrocytes, microglia, oligodendrocytes, and Schwann ...
• Collaborative Latin American Imaging Network In Neuroimmunology Research (BRAIMS): Rationale, Structure, Challenges, and Future Directions 

  Carnero Contentti, Edgar; Alonso, Ricardo; Boldrini, Vinícius; Cárcamo, Claudia A.; Casas, Magdalena; Ciampi, Ethel; Damasceno, Alfredo; dos Santos Silva, Jonadab; de Medeiros Rimkus, Carolina; Marrodán, Mariano; Navas, Carlos; Patrucco, Liliana; Pitombeira, Milena; Ramari, Cintia; Sato, Henry Koiti; Soler, Bernardita; Treviño Frenk, Irene; Wagner, Mario; Ontaneda, Daniel; Becker, Jefferson (Elsevier, 2026-06)

  Magnetic resonance imaging (MRI) plays a central role in the diagnosis, differential diagnosis, and monitoring of neuroimmunological disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder ...
• Expert Opinion on Age-Related Sex Hormone Changes and Hypogonadism in People With Multiple Sclerosis : A Delphi Consensus Program 

  Bove, Riley; Simoni, Manuela; Castelo Branco, Camil; Correale, Jorge; Hellwig, Kerstin; Houtchens, Maria K.; Magyari, Melinda; Merki-Feld, Merki-Feld; Montgomery, Scott; Nappi, Rossella E.; Shen, Wen; Stenager, Egon; Thompson, Heidi; Tulek, Zeliha; Marhardt, Kurt; Hillert, Jan A. (Lippincott Williams & Wilkins, 2026-02-26)

  Purpose of review: As the life expectancy of people with multiple sclerosis (PwMS) increases, the importance of recognizing and addressing specific needs and challenges faced by those undergoing age-related sex hormone ...
• Characterizing double seronegative neuromyelitis optica spectrum disorder: A distinct subgroup or part of the continuum? 

  Piedrabuena, María Agustina; Marrodán, Mariano; Zárate, María Agustina; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Elsevier, 2025-12-01)

  Background: Neuromyelitis optica spectrum disorder (NMOSD) encompasses inflammatory demyelinating CNS conditions. Patients negative for aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies ...
• The Neurochemical Landscape of Oligodendrocyte Physiology: From Myelination to Metabolic and Synaptic Modulation 

  Correale, Jorge (Wiley, 2025-12-11)

  Oligodendrocytes, traditionally recognized for their role in axonal myelination, are increasingly appreciated as metabolically dynamic and functionally diverse cells integral to central nervous system (CNS) homeostasis. ...
• Childhood and Adolescent Environmental Risk Factors for Multiple Sclerosis: A Systematic Review With Meta-Analysis 

  Vitturi, Bruno Kusznir; Cellerino, Maria; Boccia, Daniele; Leray, Emmanuelle; Correale, Jorge; Dobson, Ruth; van der Mei, Ingrid; Fujihara, Kazuo; Inglese, Matilde (Wiley, 2025-10-28)

  Background: We aimed to provide updated evidence from the current literature regarding pediatric environmental factors associated with the risk of developing multiple sclerosis (MS). Methods: Articles were searched in ...
• Efficacy and safety of Cladribine as a therapeutic option in multiple sclerosis patients over 50 years of age: A real-world study 

  Piedrabuena, María Agustina; Correale, Jorge; Silva, Berenice; Fiol, Marcela Paula; Marrodán, Mariano; Zárate, María Agustina; Heriz, Alejandra; Ayerbe, Jeremías; Míguez, Jimena; Pita, Cecilia; Lázaro, Luciana; Casas, Magdalena; López, Pablo Adrián; Tkachuk, Verónica; Balbuena, María Eugenia; Nadur, Débora; Liwacki, Susana; Luetic, Geraldine; Burgos, Marcos; Ysrraelit, María Célica (Elsevier, 2025-11-15)

  Background: Despite an aging multiple sclerosis (MS) population, clinical outcomes and long-termeffects of disease-modifying therapies in patients aged ≥50 years remain under-studied. Objective: To compare the efficacy ...
• Therapeutic Plasma Exchange in Corticosteroid-Refractory Multiple Sclerosis Relapses: Mechanisms, Efficacy, and Integration into Clinical Practice 

  Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge (MDPI, 2025-09-30)

  Therapeutic plasma exchange (TPE) is increasingly recognized as a critical escalation therapy for managing acute multiple sclerosis (MS) relapses refractory to high-dose corticosteroids. Neuropathological and clinical ...
• Anti-NMDAR encephalitis across the lifespan: Clinical, electrophysiological, and prognostic insights from a Latin American cohort 

  Marrodán, Mariano; Perez Arana, Carolina I.; Kirchner, Ricardo J.; Varela, Francisco José; Orzuza, Gabriela I.; Schteinschnaider, Ángeles; Chaderevian, Miriam G.; Vita, Cristina; Farez, Mauricio Franco; Correale, Jorge (Elsevier, 2025-12-15)

  Background and objectives: Anti-N-Methyl-d-aspartate receptor encephalitis (NMDARE) is the most prevalent autoimmune encephalitis, primarily affecting young females. Its clinical heterogeneity, particularly in underrepresented ...
• Iron Deficiency in Drosophila melanogaster Glial Cells Impacts Behavior Through Altered Mitochondrial Dynamics 

  Marcora, María S.; Katz, Maximiliano J.; Galo, Azul; Bochicchio, Pablo; Bongiovanni, Vinicius; Bodín, Diego H.; Pagani, Mario R.; Correale, Jorge; Pasquini, María J. (Wiley, 2025-11-10)

  Iron deficiency (ID) is the most common micronutrient deficiency globally. ID in pre- and post-natal periods has been associated with impaired neurological development and altered behavior, which may persist despite iron ...
• Intranasal delivery route for neurodegenerative diseases: recent insights and future directions 

  Correale, Jorge; Mattera, Vanesa; Pasquini, Juana María (Springer, 2025-07-29)

  Neurodegenerative diseases are increasingly significant causes of mortality and morbidity worldwide, particularly among the elderly. Despite their widespread prevalence, effective treatment options remain inadequate. A ...
• Induction of immune tolerance in NMOSD and MOGAD 

  Correale, Jorge; Carnero Contentti, Edgar (Sage, 2025-08-01)

  Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are autoimmune diseases characterized by immune-mediated damage to the central nervous system. ...
• Consenso Argentino de Diagnóstico y Tratamiento de Encefalitis Autoinmune en Adultos (CARENAI) 

  Barboza, Andrés; Fernández, María Cecilia; Hryb, Javier; Latini, Manuel Facundo; Mangone, Carlos Alberto; Manin, Analisa; Marrodán, Mariano; Pereira de Silva, Nahuel; Pérez Akly, Manuel; Rojas, Galeno; Romano, Lucas; Rugilo, Carlos; Sánchez, Marina; Tourreilles, Martin; Villa, Andrés; Yorio, Florencia; Zuin, Daniel (Elsevier, 2025-07)

  Introducción La encefalitis autoinmune (EAI) es un campo en rápido crecimiento dentro de la neurología, con mayor reconocimiento gracias a los avances en la detección de anticuerpos. A pesar de su creciente incidencia, ...
• Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria 

  Montalban, Xavier; Lebrun-Frénay, Christine; Oh, Jiwon; Arrambide, Georgina; Moccia, Marcello; Amato, Maria Pia; Amezcua, Lilyana; Banwell, Brenda; Bar-Or, Amit; Barkhof, Frederik; Butzkueven, Helmut; Ciccarelli, Olga; Chataway, Jeremy; Cohen, Jeffrey A.; Comi, Giancarlo; Correale, Jorge; Deisenhammer, Florian; Filippi, Massimo; Fiol, Julie; Freedman, Mark S. (Elsevier, 2025-09-17)

  Advances in the understanding of multiple sclerosis and the development of biomarkers of pathophysiology prompted a substantial revision of the 2017 McDonald diagnostic criteria. The new 2024 McDonald criteria provide a ...
• The immunological role of oligodendrocytes: beyond myelin maintenance 

  Pasquini, Juana M.; Correale, Jorge (Oxford University Press on behalf of the British Society for Immunology, 2025-04-28)

  Oligodendrocytes (OGDs) are well-established cells in the central nervous system (CNS), primarily recognized for their role in myelination. However, emerging evidence suggests intrinsic differences among OGDs that may lead ...

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