• New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis 

  Carrera Silva, Eugenio Antonio; Correale, Jorge; Rothlin, Carla; Ortiz Wilczyñski, Juan Manuel (American Society for Pharmacology and Experimental Therapeutics, 2024-10-08)

  Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based ...
• Differential diagnosis of suspected multiple sclerosis: global health considerations 

  Correale, Jorge; Solomon, Andrew J.; Cohen, Jeffrey A.; Banwell, Brenda L.; Gracia, Fernando; Gyang, Tirisham V.; Diaz de Bedoya, Fernando Hamuy; Harnegie, Mary P.; Hemmer, Bernhard; Jacob, Anu; Kim, Ho Jin; Marrie, Ruth Ann; Matee, Farrah J.; Newsome, Scott D.; Pandit, Lekha; Prayoonwiwat, Naraporn; Sahraian, Mohammad A.; Sato, Douglas K.; Saylor, Deanna; Shi, Fu-Dong; Siva, Aksel; Tan, Kevin; Viswanathan, Shanthi; Wattjes, Mike P.; Weinshenker, Brian; Yamout, Bassem; Fujihara, Kazuo (Lancet Pub. Group, 2024-10)

  The differential diagnosis of multiple sclerosis can present specific challenges in patients from Latin America, Africa, the Middle East, eastern Europe, southeast Asia, and the Western Pacific. In these areas, environmental ...
• The Risk of Multiple Sclerosis Relapse After Vaccination: Can a Population-Based Study of Mass Vaccination End the Longstanding Debate? 

  Abboud, Hesham; Farez, Mauricio Franco (Lippincott Williams & Wilkins, 2024-08-10)
• Telomere length as a biomarker in multiple sclerosis 

  Piedrabuena, María Agustina; Correale, Jorge; Farez, Mauricio Franco; Rodríguez Murúa, Sofía; Martínez Canyazo, Carlos; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (SAGE Publications, 2024-09-09)

  Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS). Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to ...
• Traditional first-line treatment failure rates in neuromyelitis optica spectrum disorder patients included in the Argentinean registry (RelevarEM) 

  Carnero Contentti, Edgar; Lopez, Pablo A.; Patrucco, Liliana; Cristiano, Edgardo; Miguez, Jimena; Silva, Berenice; Liwacki, Susana; Tkachuk, Verónica; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Leguizamon, Felisa; Luetic, Geraldine; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Burgos, Marcos; Hryb, Javier; Barboza, Andrés; Lazaro, Luciana; Alonso, Ricardo; Fernández Liguori, Nora; Nadur, Débora; Martínez, Alejandra; Steinberg, Judith; Carrá, Adriana; Alonso Serena, Marina; Rojas, Juan I. (Elsevier, 2024-09)

  Background: Immunosuppressive therapies as azathioprine (AZA), mycophenolate mofetil (MMF) and rituximab (RTX) are widely prescribed as first-line treatment to prevent relapses in NMOSD. However, the rate of response to ...
• Diagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis 

  Marrodán, Mariano; Calandri, Ismael Luis; Bocancea, Diana I.; Ysrraelit, María Célica; Gómez Figueroa, Enrique; Massó Páez, Montserrat; Flores, José D.J.; Rojas, Juan I.; Ciampi, Ethel; Ioli, Pablo; Zanga, Gisela; Ardohain, Carolina; Fracaro, Maria E.; Amaya, Mariela; Tkachuk, Verónica; Fernández, Victoria C.; José, Gustavo; Silva, Emanuel; Luetic, Geraldine; Carnero Contentti, Edgar; Köhler, Eduardo; Pagani Cassara, Fátima; Morán, Dolores; Seimandi, Carla; Paviolo, Juan P.; D'elio, Brenda; Da Prat, Gustavo; Gatto, Emilia; Cristiano, Edgardo; Pujol Lereis, Virginia Andrea; Ameriso, Sebastián Francisco; Fiol, Marcela Paula; Correale, Jorge (Wiley-Liss, 2024-07-26)

  Objective: Susac syndrome (SuS), multiple sclerosis (MS), and primary angiitis of the central nervous system (PACNS) present diagnostic challenges due to overlapping clinical features. We aimed to enhance diagnostic precision ...
• The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact 

  Kalaria, Raj; Maestre, Gladys; Mahinrad, Simin; Acosta, Daisy M.; Akinyemi, Rufus Olusola; Alladi, Suvarna; Allegri, Ricardo Francisco; Arshad, Faheem; Babalola, David Oluwasayo; Baiyewu, Olusegun; Bak, Thomas H.; Bellaj, Tarek; Brodie-Mends, David K.; Carrillo, Maria C.; Celestin, Kaputu-Kalala-Malu; Damasceno, Albertino; de Silva, Ranil Karunamuni; de Silva, Rohan; Djibuti, Mamuka; Dreyer, Anna Jane (John Wiley & Sons, Ltd., 2024-05-02)

  Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of ...
• Human chorionic gonadotropin regulates cytokine production by lymphocytes from patients with multiple sclerosis 

  Juriol, Lorena; Valeff, Natalín; Dibo, Marcos; Ventimiglia, María Silvia; Correale, Jorge; Jensen, Federico (Elsevier/North-Holland Biomedical Press, 2024-06-12)

  Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults, predominantly females. This was partially attributed to sex differences in ...
• Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study 

  Carnero Contentti, Edgar; Lopez, Pablo A.; Pettinicchi, Juan Pablo; Miguez, Jimena; Patrucco, Liliana; Cristiano, Edgardo; Liwacki, Susana; Tkachuk, Verónica; Balbuena, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamón, Felisa; Luetic, Geraldine; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Burgos, Marcos; Hryb, Javier; Barboza, Andrés; Lazaro, Luciana; Alonso, Ricardo; Fernández Liguori, Nora; Nadur, Débora; Alonso Serena, Marina; Caride, Alejandro; Rojas, Juan I. (Elsevier, 2024-07-15)

  We aimed to assess the treatment strategies utilized in patients with neuromyelitis optica spectrum disorder (NMOSD) experiencing relapses, including their frequency, types, and response after 6 months based on the Expanded ...
• Real-World Effectiveness and Safety of Cladribine in Multiple Sclerosis: Longitudinal Data From the Nationwide Registry in Argentina 

  Rojas, Juan Ignacio; Alonso, Ricardo; Luetic, Geraldine G.; Patrucco, Liliana; Casas, Magdalena; Silva, Berenice Anabel; Miguez, Jimena; Deri, Norma; Vrech, Carlos; Liwacki, Susana; Piedrabuena, Raúl; Silva, Emanuel; Tkachuk, Verónica A.; Burgos, Marcos; Tavolini, Darío; Zanga, Gisela; Alvez Pinheiro, Amelia; Hryb, Javier Pablo; Leguizamon, Felisa; Knorre, Eduardo; López, Pablo Adrián; Martínez, Alejandra Diana; Carrá, Adriana; Alonso Serena, Marina; Cristiano, Edgardo; Correale, Jorge; Garcea, Orlando; Fernández Liguori, Nora; Carnero Contentti, Edgar (Lippincott Williams & Wilkins, 2024-05-23)

  Objective: The aim was to evaluate patient profiles, effectiveness and safety of cladribine (CLAD) in patients with relapsing-remitting multiple sclerosis in Argentina. Methods: This was a substudy included in RelevarEM ...
• Transferrin Enhances Neuronal Differentiation 

  Pérez, María Julia; Carden, Tomás Roberto; Dos Santos Claro, Paula Ayelen; Silberstein, Susana; Páez, Pablo Martin; Cheli, Veronica Teresita; Correale, Jorge; Pasquini, Juana María (Sage, 2023-04-24)

  Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse ...
• Selection of disease modifying therapies in multiple sclerosis based on patient's age and disease activity: Data from a nationwide registry 

  Piedrabuena, María Agustina; Correale, Jorge; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica (Elsevier, 2024-05-16)

  Background: Knowledge of the safety and efficacy of disease-modifying therapies (DMTs) in older patients with Multiple Sclerosis (pwMS) is limited due to their exclusion from clinical trials. Our purpose is to evaluate the ...
• Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings. 

  Pestchanker, Claudia; Bertado Cortez, Brenda; Lana Peixoto, Marco A.; Gortari, José Ignacio; Castro Suarez, Sheila; Caparo Zamalloa, César; Galiana, Graciana Lourdes; Peñalver, Francisco; Daccach Marques, Vanessa; Messias, Katharina; Galleguillos Goiry, Lorna; García, Fernando; Rojas, Juan Ignacio; Patrucco, Liliana; Cristiano, Edgardo; Tkachuk, Verónica A.; Liwacki, Susana; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Vrech, Carlos; Deri, Norma; Leguizamon, Felisa; Tavolini, Darío; Mainella, Carolina; Zanga, Gisela; Alonso Serena, Marina; Ciampi, Ethel; Herval Ribeiro Soares Neto, Herval; López, Pablo Adrián; Carnero Contentti, Edgar (Springer-Verlag, 2024-03-17)

  Introduction: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory ...
• Core data set for real world data in multiple sclerosis: customization for latin america from a global task force recommendation. 

  Rojas, Juan Ignacio; Gracia, Fernando; Parciak, T.; Alonso, R. N.; Becker, Jefferson; Treviño Frenk, Irene; Alonso Serena, Marina; Giunta, Diego Hernán; Abad, P.; Carnero Contentti, Edgar; Carrá, Adriana; Correa Díaz, Edgar Patricio; Correale, Jorge; Cristiano, Edgardo; Flores, José; Fruns, Manuel; Galleguillos Goiry, Lorna; Garcea, Orlando; Hamuy, Fernando; Lana Peixoto, Marco A.; Navas, Carlos; Papais Alvarenga, Regina; Patrucco, Liliana; Rivera, V.; Tenembaum, S. N.; Ysrraelit, María Célica; Peeters, L.M. (Viguera, 2024-04-01)

  Introduction: The primary objective of the core data set is to reduce heterogeneity and promote harmonization among data sources in EM, thereby reducing the time needed to execute real life data collection efforts. Recently, ...
• Comorbidities in multiple sclerosis and their influence on the choice of treatment 

  Barboza, Andrés G.; Sinay, Vladimiro; Alonso, Ricardo; Carnero Contentti, Edgar; Hryb, Javier Pablo; Silva, Berenice Anabel; Tavolini, Darío; Ysrraelit, María Célica; Correale, Jorge (Revista de Neurología, 2024-03-16)

  Los estudios clínicos de tratamientos para personas con esclerosis múltiple (pEM) se realizan en poblaciones seleccionadas, que excluyen a pacientes que presenten comorbilidades o medicaciones concomitantes. Sin embargo, ...
• Remyelinating effect driven by transferrin-loaded extracellular vesicles 

  Mattera, Vanesa S.; Occhiuzzi, Federico; Correale, Jorge; Pasquini, Juana María (Wiley, 2023-10-20)

  Extracellular vesicles (EVs) are involved in diverse cellular functions, playing a significant role in cell-to-cell communication in both physiological conditions and pathological scenarios. Therefore, EVs represent a ...
• Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry 

  Carnero Contentti, Edgar; López, Pablo Adrián; Pettinicchi, Juan Pablo; Criniti, Juan; Pappolla, Agustín; Miguez, Jimena; Cristiano, Edgardo; Patrucco, Liliana; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine G.; Menichini, María Laura; Tavolini, Darío (Sage, 2023-10-17)

  We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) ...
• A plain language summary on assessing the long-term effectiveness of cladribine tablets in people living with relapsing multiple sclerosis: The CLASSIC-MS study 

  Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; Verdun di Cantogno, Elisabetta (Future Medicine, 2023-08-03)

  What is this summary about?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 ...
• Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes 

  Wies Mancini, Victoria Sofía Berenice; Mattera, Vanesa S.; Pasquini, Juana María; Pasquini, Laura Andrea; Correale, Jorge (Wiley on behalf of the International Society for Neurochemistry, 2023-12-06)

  Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively ...
• Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina 

  Carnero Contentti, Edgar; López, Pablo Adrián; Pappolla, Agustín; Alonso, Ricardo; Silva, Berenice Anabel; Deri, Norma; Balbuena Aguirre, María Eugenia; Burgos, Marcos; Luetic, Geraldine G.; Alvez Pinheiro, Amelia; Cabrera, Mariela; Hryb, Javier Pablo; Nofal, Pedro G.; Pestchanker, Claudia; Vrech, Carlos; Tavolini, Darío; Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge; RelevarEM investigators (Springer-Verlag Italia, 2023-12-30)

  We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina ...

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