• Childhood and Adolescent Environmental Risk Factors for Multiple Sclerosis: A Systematic Review With Meta-Analysis 

  Vitturi, Bruno Kusznir; Cellerino, Maria; Boccia, Daniele; Leray, Emmanuelle; Correale, Jorge; Dobson, Ruth; van der Mei, Ingrid; Fujihara, Kazuo; Inglese, Matilde (Wiley, 2025-10-28)

  Background: We aimed to provide updated evidence from the current literature regarding pediatric environmental factors associated with the risk of developing multiple sclerosis (MS). Methods: Articles were searched in ...
• Efficacy and safety of Cladribine as a therapeutic option in multiple sclerosis patients over 50 years of age: A real-world study 

  Piedrabuena, María Agustina; Correale, Jorge; Silva, Berenice; Fiol, Marcela; Marrodán, Mariano; Zárate, María Agustina; Heriz, Alejandra; Ayerbe, Jeremías; Míguez, Jimena; Pita, Cecilia; Lázaro, Luciana; Casas, Magdalena; López, Pablo Adrián; Tkachuk, Verónica; Balbuena, María Eugenia; Nadur, Débora; Liwacki, Susana; Luetic, Geraldine; Burgos, Marcos; Ysrraelit, María Célica (Elsevier, 2025-11-15)

  Background: Despite an aging multiple sclerosis (MS) population, clinical outcomes and long-termeffects of disease-modifying therapies in patients aged ≥50 years remain under-studied. Objective: To compare the efficacy ...
• Therapeutic Plasma Exchange in Corticosteroid-Refractory Multiple Sclerosis Relapses: Mechanisms, Efficacy, and Integration into Clinical Practice 

  Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge (MDPI, 2025-09-30)

  Therapeutic plasma exchange (TPE) is increasingly recognized as a critical escalation therapy for managing acute multiple sclerosis (MS) relapses refractory to high-dose corticosteroids. Neuropathological and clinical ...
• Anti-NMDAR encephalitis across the lifespan: Clinical, electrophysiological, and prognostic insights from a Latin American cohort 

  Marrodán, Mariano; Perez Arana, Carolina I.; Kirchner, Ricardo J.; Varela, Francisco José; Orzuza, Gabriela I.; Schteinschnaider, Ángeles; Chaderevian, Miriam G.; Vita, Cristina; Farez, Mauricio Franco; Correale, Jorge (Elsevier, 2025-12-15)

  Background and objectives: Anti-N-Methyl-d-aspartate receptor encephalitis (NMDARE) is the most prevalent autoimmune encephalitis, primarily affecting young females. Its clinical heterogeneity, particularly in underrepresented ...
• Iron Deficiency in Drosophila melanogaster Glial Cells Impacts Behavior Through Altered Mitochondrial Dynamics 

  Marcora, María S.; Katz, Maximiliano J.; Galo, Azul; Bochicchio, Pablo; Bongiovanni, Vinicius; Bodín, Diego H.; Pagani, Mario R.; Correale, Jorge; Pasquini, María J. (Wiley, 2025-11-10)

  Iron deficiency (ID) is the most common micronutrient deficiency globally. ID in pre- and post-natal periods has been associated with impaired neurological development and altered behavior, which may persist despite iron ...
• Intranasal delivery route for neurodegenerative diseases: recent insights and future directions 

  Correale, Jorge; Mattera, Vanesa; Pasquini, Juana María (Springer, 2025-07-29)

  Neurodegenerative diseases are increasingly significant causes of mortality and morbidity worldwide, particularly among the elderly. Despite their widespread prevalence, effective treatment options remain inadequate. A ...
• Induction of immune tolerance in NMOSD and MOGAD 

  Correale, Jorge; Carnero Contentti, Edgar (Sage, 2025-08-01)

  Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are autoimmune diseases characterized by immune-mediated damage to the central nervous system. ...
• Consenso Argentino de Diagnóstico y Tratamiento de Encefalitis Autoinmune en Adultos (CARENAI) 

  Barboza, Andrés; Fernández, María Cecilia; Hryb, Javier; Latini, Manuel Facundo; Mangone, Carlos Alberto; Manin, Analisa; Marrodán, Mariano; Pereira de Silva, Nahuel; Pérez Akly, Manuel; Rojas, Galeno; Romano, Lucas; Rugilo, Carlos; Sánchez, Marina; Tourreilles, Martin; Villa, Andrés; Yorio, Florencia; Zuin, Daniel (Elsevier, 2025-07)

  Introducción La encefalitis autoinmune (EAI) es un campo en rápido crecimiento dentro de la neurología, con mayor reconocimiento gracias a los avances en la detección de anticuerpos. A pesar de su creciente incidencia, ...
• Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria 

  Montalban, Xavier; Lebrun-Frénay, Christine; Oh, Jiwon; Arrambide, Georgina; Moccia, Marcello; Amato, Maria Pia; Amezcua, Lilyana; Banwell, Brenda; Bar-Or, Amit; Barkhof, Frederik; Butzkueven, Helmut; Ciccarelli, Olga; Chataway, Jeremy; Cohen, Jeffrey A.; Comi, Giancarlo; Correale, Jorge; Deisenhammer, Florian; Filippi, Massimo; Fiol, Julie; Freedman, Mark S. (Elsevier, 2025-09-17)

  Advances in the understanding of multiple sclerosis and the development of biomarkers of pathophysiology prompted a substantial revision of the 2017 McDonald diagnostic criteria. The new 2024 McDonald criteria provide a ...
• The immunological role of oligodendrocytes: beyond myelin maintenance 

  Pasquini, Juana M.; Correale, Jorge (Oxford University Press on behalf of the British Society for Immunology, 2025-04-28)

  Oligodendrocytes (OGDs) are well-established cells in the central nervous system (CNS), primarily recognized for their role in myelination. However, emerging evidence suggests intrinsic differences among OGDs that may lead ...
• Factors for Rituximab Refractoriness in AQP4-IgG+ NMOSD: A Cohort Study 

  Marrodán, Mariano; Piedrabuena, María Agustina; Zárate, María Agustina; Rodríguez Murúa, Sofía; Surace, Ezequiel Ignacio; Farez, Mauricio Franco; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Wiley Periodicals, 2025-08)

  Objective: Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin-4 antibodies (AQP4-IgG). Rituximab, a CD20+ B-cell depleting ...
• Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome 

  Fissolo, Nicolás; Schaedelin, Sabine; Villar, Luisa M.; Lünemann, Jan D.; Correale, Jorge; Rejdak, Konrad; Schwab, Nicholas; Vilaseca, Andreu; Held, Friederike; García-Merino, Antonio; Bittner, Stefan; Trojano, María; Furlan, Roberto; Tumani, Hayrettin; Pérez-Miralles, Francisco; Rosenstein, Igal; Galimberti, Daniela; Álvarez-Bravo, Gary; Thouvenot, Eric; Llufriu, Sara (American Medical Associatio, 2025-07-01)

  Importance: Understanding the risk factors for symptom development will allow clinicians to stratify people with radiologically isolated syndrome (pwRIS) more effectively and tailor their management strategies accordingl ...
• Development of early progression independent of relapse activity significantly impacts on disability accumulation in patients with multiple sclerosis 

  Zárate, María Agustina; Marrodán, Mariano; Piedrabuena, María Agustina; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge (Elsevier, 2025-05-14)

  Background: Disability accumulation in multiple sclerosis (MS) is driven by relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA). Early PIRA (EP), occurring within five years of disease ...
• Latin American RAND/UCLA modified Delphi consensus recommendations for management and treatment of adult MOGAD patients in clinical practice 

  Carnero Contentti, Edgar; Correale, Jorge; Rojas, Juan I.; Alonso, Ricardo; Becker, Jefferson; Caparó Zamalloa, César; Correa-Díaz, Edgar Patricio; Flores-Rivera, José; Jiménez Arango, Jorge A.; Lana Peixoto, Marco A.; Navas, Carlos; Pataruco, Liliana; Rivera, Víctor M.; Sato, Douglas K.; Soto de Castillo, Ibis; Tkachuk, Verónica; Levy, Michael; Paul, Friedemann (Elsevier, 2025-04-20)

  Introduction: Over the last decade, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has seen significant advancements, with new diagnostic criteria and emerging biomarkers, increased recognition of ...
• Impact of oral Cladribine on paramagnetic rim lesions of Multiple Sclerosis patients 

  Marrodán, Mariano; Yañez, Paulina; Calandri, Ismael Luis; Piedrabuena, María Agustina; Zárate, María Agustina; Ysrraelit, María Célica; Fiol, Marcela Paula; Correale, Jorge (Elsevier, 2025-02-22)

  Background: Paramagnetic rim lesions (PRLs), marked by chronic inflammation and iron-loaded microglia, are linked to severe disease progression in multiple sclerosis (MS). The impact of cladribine, an immune reconstitution ...
• Toward equity in MS care: A roadmap for accessible treatment 

  Correale, Jorge (Sage, 2025-03-17)

  Resumen no disponible
• Long-term follow-up of patients with a first clinical demyelinating event (clinically isolated syndrome) who received cladribine tablets in CLASSIC-MS: Findings for the ORACLE-MS cohort 

  Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; di Cantogno, Elisabetta Verdun (SAGE, 2024-12-17)

  Background: CLASSIC-MS explored long-term outcomes of patients treated with cladribine tablets. Objective: Assess long-term efficacy in patients previously enrolled in ORACLE-MS, a Phase III parent trial. Methods: ...
• Frailty and Implications for Multiple Sclerosis Management 

  Correale, Jorge (American Medical Association, 2025-03-03)

  This Viewpoint discusses the unique needs of patients with multiple sclerosis and frailty and describes the gaps that should be addressed in frailty measurement and clinical management.
• Emerging immune tolerance therapies for neuromyelitis optica spectrum disorder 

  Carnero Contentti, Edgar; Correale, Jorge (Taylor & Francis, 2025-02-23)

  Resumen no disponible
• Live-attenuated vaccines for multiple sclerosis patients living in regions with endemic infections: A complex decision 

  Correale, Jorge; Marrodán, Mariano (Sage, 2024-12-18)

  Live-attenuated vaccines provide robust immunity against diseases like tuberculosis, measles, mumps, rubella, polio, yellow fever, dengue, typhoid fever, and varicella, with just one or a few doses. However, concerns arise ...

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