Objective: Susac syndrome (SuS), multiple sclerosis (MS), and primary angiitis of the central nervous system (PACNS) present diagnostic challenges due to overlapping clinical features. We aimed to enhance diagnostic precision ...
Kalaria, Raj; Maestre, Gladys; Mahinrad, Simin; Acosta, Daisy M.; Akinyemi, Rufus Olusola; Alladi, Suvarna; Allegri, Ricardo Francisco; Arshad, Faheem; Babalola, David Oluwasayo; Baiyewu, Olusegun; Bak, Thomas H.; Bellaj, Tarek; Brodie-Mends, David K.; Carrillo, Maria C.; Celestin, Kaputu-Kalala-Malu; Damasceno, Albertino; de Silva, Ranil Karunamuni; de Silva, Rohan; Djibuti, Mamuka; Dreyer, Anna Jane(John Wiley & Sons, Ltd., 2024-05-02)
Two of every three persons living with dementia reside in low- and middle-income countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of ...
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults, predominantly females. This was partially attributed to sex differences in ...
We aimed to assess the treatment strategies utilized in patients with neuromyelitis optica spectrum disorder (NMOSD) experiencing relapses, including their frequency, types, and response after 6 months based on the Expanded ...
Objective: The aim was to evaluate patient profiles, effectiveness and safety of cladribine (CLAD) in patients with relapsing-remitting multiple sclerosis in Argentina.
Methods: This was a substudy included in RelevarEM ...
Pérez, María Julia; Carden, Tomás Roberto; Dos Santos Claro, Paula Ayelen; Silberstein, Susana; Páez, Pablo Martin; Cheli, Veronica Teresita; Correale, Jorge; Pasquini, Juana María(Sage, 2023-04-24)
Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse ...
Zarate, María Agustina; Marrodán, Mariano; Piedrabuena, María Agustina; Fiol, Marcela Paula; Ysrraelit, María Célica; Correale, Jorge(American Academy of Neurology, 2024-04-09)
Objective:
To analyze characteristics of patients with secondary progressive Multiple Sclerosis (SPMS) exhibiting Progression Independent of Relapse Activity (PIRA) and to identify factors contributing to earlier ...
Piedrabuena, María Agustina; Correale, Jorge; Fiol, Marcela Paula; Marrodán, Mariano; Ysrraelit, María Célica(Elsevier, 2024-05-16)
Background: Knowledge of the safety and efficacy of disease-modifying therapies (DMTs) in older patients with Multiple Sclerosis (pwMS) is limited due to their exclusion from clinical trials. Our purpose is to evaluate the ...
Introduction: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory ...
Rojas, Juan Ignacio; Gracia, Fernando; Parciak, T.; Alonso, R. N.; Becker, Jefferson; Treviño Frenk, Irene; Alonso Serena, Marina; Giunta, Diego Hernán; Abad, P.; Carnero Contentti, Edgar; Carrá, Adriana; Correa Díaz, Edgar Patricio; Correale, Jorge; Cristiano, Edgardo; Flores, José; Fruns, Manuel; Galleguillos Goiry, Lorna; Garcea, Orlando; Hamuy, Fernando; Lana Peixoto, Marco A.; Navas, Carlos; Papais Alvarenga, Regina; Patrucco, Liliana; Rivera, V.; Tenembaum, S. N.; Ysrraelit, María Célica; Peeters, L.M.(Viguera, 2024-04-01)
Introduction: The primary objective of the core data set is to reduce heterogeneity and promote harmonization among data sources in EM, thereby reducing the time needed to execute real life data collection efforts. Recently, ...
Barboza, Andrés G.; Sinay, Vladimiro; Alonso, Ricardo; Carnero Contentti, Edgar; Hryb, Javier Pablo; Silva, Berenice Anabel; Tavolini, Darío; Ysrraelit, María Célica; Correale, Jorge(Revista de Neurología, 2024-03-16)
Los estudios clínicos de tratamientos para personas con esclerosis múltiple (pEM) se realizan en poblaciones seleccionadas, que excluyen a pacientes que presenten comorbilidades o medicaciones concomitantes. Sin embargo, ...
Extracellular vesicles (EVs) are involved in diverse cellular functions, playing a significant role in cell-to-cell communication in both physiological conditions and pathological scenarios. Therefore, EVs represent a ...
Carnero Contentti, Edgar; López, Pablo Adrián; Pettinicchi, Juan Pablo; Criniti, Juan; Pappolla, Agustín; Miguez, Jimena; Cristiano, Edgardo; Patrucco, Liliana; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine G.; Menichini, María Laura; Tavolini, Darío(Sage, 2023-10-17)
We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) ...
What is this summary about?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 ...
Wies Mancini, Victoria Sofía Berenice; Mattera, Vanesa S.; Pasquini, Juana María; Pasquini, Laura Andrea; Correale, Jorge(Wiley on behalf of the International Society for Neurochemistry, 2023-12-06)
Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively ...
We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina ...
Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack Jr, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network; Alzheimer’s Disease Neuroimaging Initiative(American Medical Association, 2023-12-01)
Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains ...
Background: Most Multiple Sclerosis (MS) clinical trials fail to assess the long-term effects of disease-modifying therapies (DMT) or disability.
Methods: COLuMbus was a single-visit, cross-sectional study in Argentina ...
Background: We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis ...