• Resistance and resilience to Alzheimer's disease in Down syndrome 

  Boyle, Rory; Koops, Elouise A.; Ances, Beau; Andrews, Elizabeth J.; Arenaza-Urquijo, Eider M.; Benjanin, Alexandre; Brickman, Adam M.; Buckley, Rachel F.; Clas, Giulia Solange; Costello, Emmet; Coughlan, Gillian T.; Conley, Alexander C.; Deng, Feng; de Paula Faria, Daniele; Edwards, Natalie; Flores-Aguilar, Lisi; Fortea, Juan; Saidi, Ladan Ghazi; Head, Elizabeth; Hom, Christy L. (Wiley, 2025-04-28)

  Due to the high prevalence of Alzheimer's disease (AD) in adults with Down syndrome (DS), trisomy 21 is now considered a genetic form of AD (DSAD). A better understanding of factors that can prevent or delay AD is vital ...
• Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial 

  Bateman, Randall J.; Li, Yan; McDade, Eric M.; Llibre-Guerra, Jorge J.; Clifford, David B.; Atri, Alireza; Mills, Susan L.; Santacruz, Anna M.; Wang, Guoqiao; Supnet, Charlene; Benzinger, Tammie L. S.; Gordon, Brian A.; Ibanez, Laura; Klein, Gregory; Baudler, Monika; Doody, Rachelle S.; Delmar, Paul; Kerchner, Geoffrey A.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer's Disease–Trials Unit (Elsevier, 2025-04)

  Background: Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people ...
• Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease 

  Jiaxin Cindy, Tu; Millar, Peter R.; Strain, Jeremy F.; Eck, Andrew; Adeyemo, Babatunde; Snyder, Abraham Z.; Daniels, Alisha; Karch, Celeste; Huey, Edward D.; McDade, Eric; Day, Gregory S.; Yakushev, Igor; Hassenstab, Jason; Morris, John; Llibre-Guerra, Jorge J.; Ibanez, Laura; Jucke, Mathias; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (MIT Press, 2024)

  Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer's disease (AD). Computational ...
• 2- Cognitive Impairment and Dementia in Latin American Individuals with Parkinsonism and Parkinson’s Disease: A 10/66 Dementia Research Group Study (Ana Luisa Sosa) 

  Sosa, Ana Luisa; Khan, N.; Arruabarrena, Micaela María; Kim, D.J.; Jiang, M.; Llibre-Rodriguez, J.J.; Rodriguez-Salgado, A.M.; Acosta, I.; Acosta, D.; Jimenez-Velasquez, I.Z.; Guerra, M.; Salas, A.; López-Contreras, R.; Dhara, Santana; Hesse, H.; Tanner, C.; Prina, M.; Llibre-Guerra, J.J.; 10/66 Dementia ResearchGroup (International Psichogeriatrics Association, 2024-09)
• Protocolo de valoración neuroconductual estandarizada y de interpretación clínica de pacientes con trastornos crónicos de conciencia 

  Russo, María Julieta; Pavón, Hernán Marcelo; Deschle, Florencia; Marroquín, María Verónica; Aliaga, Orlando; Sampayo, María de la Paz (Elsevier, 2025-03-20)

  En este trabajo investigamos la literatura existente acerca de la posibilidad de que algunos hallazgos clínicos puedan ser de utilidad para el diagnóstico de la presencia de contenido de conciencia en los pacientes con ...
• Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 

  Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)

  We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...
• Experts envision a valuable role for tau-PET in clinical practiceand drug trials 

  Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley, 2024)

  Background: Recent advancements in Alzheimer’s disease (AD) biomarker researchand AD drug trials prompt reflection on the value and appropriate use of tau-PET infuture clinical practice and trials. We therefore conducted ...
• Development of a Multidomain Composite InterventionEngagement Score in the U.S. POINTER Trial 

  Ghadimi Nouran, Mina; Katula, Jeffrey A.; Ventrelle, Jennifer; Graef, Sarah; Garcia, Katelyn R.; Lovato, Laura; Wilmoth, Sharon; Woolard, Nancy; Leng, Xiaoyan; Calandri, Ismael Luis; Snyder, Heather M.; Bake, Laura D. (Wiley, 2024)

  Background Multidomain lifestyle interventions have shown promise to slow cognitive decline and possibly prevent dementia. However, challenges arise in analyzing and interpreting treatment response when participants vary ...
• Multi-Component and Cognitive Skills Training in MildCognitive Impairment: Outcomes from a South American Study 

  Martín, María Eugenia; Martínez, Carlos; Worff, Iris; Belucci, María Agustina; Keller, Greta; Arruabarrena, Micaela María; Corvalàn, Nicolás; Clarens, María Florencia; Allegri, Ricardo Francisco; Crivelli, Lucía (Wiley, 2024)

  Background: Dementia represents a significant health challenge, with evidencesuggesting that it can be potentially delayed or prevented through non-pharmacological interventions. There are different types of non-pharmaco ...
• Is FDG-PET metabolism associated with cognitive performancein long-Covid patients? 

  Hernández, Micaela Anahí; Santos Machado, Luiza; De Bastiani, Marco; Hugentobler Schlickmann, Thomas; Ferrari-Souza, João Pedro; Carello, Agostina; Helou, María Belén; Crivelli, Lucía; Osa Sanz, Emilia; Bérgamo, Yanina; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; Zimmer, Eduardo R.; Calandri, Ismael Luis (Wiley, 2024)

  Background: Current evidence indicates that COVID-19 infection can lead toneurological complications that persist beyond 12 weeks of infection (long-COVID),often associated with cognitive decline. However, the underlying ...
• Multi-modal AI screening for MCI and Alzheimer's Disease: results from an Argentine Cohort 

  Belloli, Laouen; Keller, Greta; Carello, Agostina; Gauder, Lara; Juantorena, Gustavo; Corvalan, Nicolás; Allegri, Ricardo Francisco; Crivelli, Lucía; Fernández Slezak, Diego (Wiley, 2024)

  Early detection of Mild Cognitive Impairment (MCI) is crucial for effective prevention. Traditional methods like expert judgment, clinical evaluations, and manual linguistic analyses are now complemented by Artificial ...
• Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America 

  Cubas Guillen, Jonathan Fernando; Ardohain, Carolina; Berrios, Waleska; Deschle, Florencia; Dorman, Guido; Fernandez Boccazzi, Julian; Flores, Ignacio; Graviotto, Héctor Gastón; Isaac, Cristian Flavio; Rojas, Galeno; Román, Karen Daniela; Scribano Parada, Maria de la Paz; Sorbara, Marcos; Allegri, Ricardo Francisco; Calandri, Ismael Luis (IOS Press, 2025-01-31)

  Background: Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases. Objective: The ...
• Brain metabolic subtypes in Long Covid individuals from a Brazilian cohort 

  Viana Jotz, Arthur; De Bastiani, Marco; Santos Machado, Luiza; Hugentobler Schlickmann, Thomas; Silveira, Maiele Dornelles; Senger, Joana Emilia; Vendramini Borelli, Wyllians; Ferrari‐Souza, João Pedro; Povala, Guilherme; Bornes da Silva, Ana Paula; Uglione da Ros, João Pedro; Bastos de Mello, Guilherme; Fakhri Kadan, Matheus; Radaelli, Graciane; de Paula de Paula Faria, Daniele; Martins Coutinho, Artur; Lourenco, Mychael V.; Hernández, Micaela Anahí; Calandri, Ismael Luis; Pascoal, Tharick A.; Matushita, Cristina Sebastião; Benardi Soder, Ricardo; Schumacher‐Schuh, Artur Francisco; Souza, Diogo O.; Costa da Costa, Jaderson; Guerini de Souza, Débora; Zimmer, Eduardo R. (John Wiley & Sons, 2024)

  Background: The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is one of the biggest health concerns of the century. Long COVID is one of the major sequelae from the infection and include persistent neurological ...
• Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations 

  Farina, Francesca R.; Bridgeman, Katie; Gregory, Sarah; Crivelli, Lucía; Foote, Isabelle F.; Jutila, Otto-Emil I.; Kucikova, Ludmila; Mariano, Luciano I.; Nguyen, Kim-Huong; Thayanandan, Tony; Akindejoye, Funmi; Butler, Joe; Calandri, Ismael Luis; Čepukaitytė, Giedrė; Chiesa, Scott T.; Dawson, Walter D.; Deckers, Kay; De la Cruz-Góngora, Vanessa; Dounavi, Maria-Eleni; Govia, Ishtar (Elsevier, 2024-12-20)

  fforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a ...
• Risk factors and baseline cognition. Preliminary results from the LatAm-FINGERS cohort 

  Corvalán, Nicolás; Keller, Greta; Surace, Ezequiel Ignacio; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Monica; Allegri, Ricardo Francisco; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Sevlever, Gustavo Emilio; Crivelli, Lucía; LatAm-FINGERS Consortium (Wiley, 2024)

  Background LatAm-FINGERS - the first non-pharmacological multicenter randomized clinical trial in Latin America - is a valuable opportunity to study lifestyle in a heterogeneous and multiethnic population exposed to a ...
• Case report: A 50 year-old Down syndrome man exhibiting noAlzheimer’s disease biomarker profile nor cognitiveimpairment. Experience from the Argentine Initiative for theStudy of Down syndrome and Alzheimer’s 

  Clas, Giulia Solange; Pertierr, Lucía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda; Magrath Guimet, Nahuel; Allegri, Ricardo Francisco; Marazita, Mariela Claudia; Romorini, Leonardo; Surace, Ezequiel Ignacio (Wiley, 2024)

  Background: Down Syndrome (DS) is the most common genetic form of intellectualdisability. In recent years, there has been a significant increase in the life expectancyof individuals with DS, currently reaching the age of ...
• The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset. 

  Liu, Haiyan; Marsh, Thomas W.; Shi, Xinyu; Renton, Alan E.; Bowling, Kevin M.; Ziegemeier, Ellen; Wang, Guoqiao; Cao, Yuchen; Aristel, Alisha; Li, Jessie; Dickson, Alexa; Perrin, Richard J.; Goate, Alison M.; Fernández, Victoria; Day, Gregory S.; Doering, Michelle; Daniels, Alisha; Supnet-Bell, Charlene; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Oxford University Press, 2025-02-04)

  We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). A total of 550 variants in the APP, PSEN1, and PSEN2 genes were identified, of which 279 were ...
• Exosomal mRNA Signatures as Predictive Biomarkers for Risk and Age of Onset in Alzheimer's Disease 

  Bolívar, Daniel A.; Mosquera Heredia, María I.; Vidal, Oscar M.; Barceló, Ernesto; Allegri, Ricardo Francisco; Morales, Luis C.; Silvera Redondo, Carlos; Arcos Burgos, Mauricio; Garavito Galofre, Pilar; Vélez, Jorge I. (MDPI, 2024-11-15)

  Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. While the precise causes of AD remain unclear, emerging evidence suggests that messenger RNA (mRNA) ...
• Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review 

  Crivelli, Lucía; Winkler, Andrea Sylvia; Keller, Greta; Beretta, Simone; Calandri, Ismael Luis; De Groote, Wouter; Fornari, Arianna; Frontera, Jennifer; Kivipelto, Miia; Lopez-Rocha, Ana Sabsil; Mangialasche, Francesca; Munblit, Daniel; Palmer, Katie; Guekht, Alla; Allegri, Ricardo Francisco (Elsevier, 2025-03)

  Background This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with ...
• Survey among experts on the future role of tau-PET in clinical practice and trials 

  Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley on behalf of the Alzheimer's Association, 2024)

  Background: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the ...

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