• Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia 

  Llibre Guerra, Jorge J.; Fernandez, M. Victoria; Joseph-Mathurin, Nelly; Bian, Shijia; Carter, Kathleen; Li, Yan; Aschenbrenner, Andrew J.; Pottier, Cyril; Sigurdson, Wendy; McDade, Eric; Gordon, Brian A.; Renton, Alan E.; Benzinger, Tammie L. S.; Ibañez, Laura; Barthelemy, Nico; Dominantly Inherited Alzheimer Network (Nature Publishing Company, 2025-02-10)

  We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic ...
• Experts envision a valuable role for tau-PET in clinical practiceand drug trials 

  Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley, 2024)

  Background: Recent advancements in Alzheimer’s disease (AD) biomarker researchand AD drug trials prompt reflection on the value and appropriate use of tau-PET infuture clinical practice and trials. We therefore conducted ...
• Development of a Multidomain Composite InterventionEngagement Score in the U.S. POINTER Trial 

  Ghadimi Nouran, Mina; Katula, Jeffrey A.; Ventrelle, Jennifer; Graef, Sarah; Garcia, Katelyn R.; Lovato, Laura; Wilmoth, Sharon; Woolard, Nancy; Leng, Xiaoyan; Calandri, Ismael Luis; Snyder, Heather M.; Bake, Laura D. (Wiley, 2024)

  Background Multidomain lifestyle interventions have shown promise to slow cognitive decline and possibly prevent dementia. However, challenges arise in analyzing and interpreting treatment response when participants vary ...
• Multi-Component and Cognitive Skills Training in MildCognitive Impairment: Outcomes from a South American Study 

  Martín, María Eugenia; Martínez, Carlos; Worff, Iris; Belucci, María Agustina; Keller, Greta; Arruabarrena, Micaela María; Corvalàn, Nicolás; Clarens, María Florencia; Allegri, Ricardo Francisco; Crivelli, Lucía (Wiley, 2024)

  Background: Dementia represents a significant health challenge, with evidencesuggesting that it can be potentially delayed or prevented through non-pharmacological interventions. There are different types of non-pharmaco ...
• Is FDG-PET metabolism associated with cognitive performancein long-Covid patients? 

  Hernández, Micaela Anahí; Santos Machado, Luiza; De Bastiani, Marco; Hugentobler Schlickmann, Thomas; Ferrari-Souza, João Pedro; Carello, Agostina; Helou, Belén; Crivelli, Lucía; Osa Sanz, Emilia; Bérgamo, Yanina; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; Zimmer, Eduardo R.; Calandri, Ismael Luis (Wiley, 2024)

  Background: Current evidence indicates that COVID-19 infection can lead toneurological complications that persist beyond 12 weeks of infection (long-COVID),often associated with cognitive decline. However, the underlying ...
• Multi-modal AI screening for MCI and Alzheimer's Disease: results from an Argentine Cohort 

  Belloli, Laouen; Keller, Greta; Carello, Agostina; Gauder, Lara; Juantorena, Gustavo; Corvalan, Nicolás; Allegri, Ricardo Francisco; Crivelli, Lucía; Fernández Slezak, Diego (Wiley, 2024)

  Early detection of Mild Cognitive Impairment (MCI) is crucial for effective prevention. Traditional methods like expert judgment, clinical evaluations, and manual linguistic analyses are now complemented by Artificial ...
• Etiologies of rapidly progressive dementias: A systematic review and meta-analysis of causes in worldwide and Latin America 

  Cubas Guillen, Jonathan Fernando; Ardohain, Carolina; Berrios, Waleska; Deschle, Florencia; Dorman, Guido; Fernandez Boccazzi, Julian; Flores, Ignacio; Graviotto, Héctor Gastón; Isaac, Cristian Flavio; Rojas, Galeno; Román, Karen Daniela; Scribano Parada, Maria de la Paz; Sorbara, Marcos; Allegri, Ricardo Francisco; Calandri, Ismael Luis (IOS Press, 2025-01-31)

  Background: Rapidly progressive dementia (RPD) is a group of neurological diseases, where three etiologies are particularly relevant: neurodegenerative, prion and autoimmune encephalitis (AIE) diseases. Objective: The ...
• Brain metabolic subtypes in Long Covid individuals from a Brazilian cohort 

  Viana Jotz, Arthur; De Bastiani, Marco; Santos Machado, Luiza; Hugentobler Schlickmann, Thomas; Silveira, Maiele Dornelles; Senger, Joana Emilia; Vendramini Borelli, Wyllians; Ferrari‐Souza, João Pedro; Povala, Guilherme; Bornes da Silva, Ana Paula; Uglione da Ros, João Pedro; Bastos de Mello, Guilherme; Fakhri Kadan, Matheus; Radaelli, Graciane; de Paula de Paula Faria, Daniele; Martins Coutinho, Artur; Lourenco, Mychael V.; Hernández, Micaela Anahí; Calandri, Ismael Luis; Pascoal, Tharick A.; Matushita, Cristina Sebastião; Benardi Soder, Ricardo; Schumacher‐Schuh, Artur Francisco; Souza, Diogo O.; Costa da Costa, Jaderson; Guerini de Souza, Débora; Zimmer, Eduardo R. (John Wiley & Sons, 2024)

  Background: The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is one of the biggest health concerns of the century. Long COVID is one of the major sequelae from the infection and include persistent neurological ...
• Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations 

  Farina, Francesca R.; Bridgeman, Katie; Gregory, Sarah; Crivelli, Lucía; Foote, Isabelle F.; Jutila, Otto-Emil I.; Kucikova, Ludmila; Mariano, Luciano I.; Nguyen, Kim-Huong; Thayanandan, Tony; Akindejoye, Funmi; Butler, Joe; Calandri, Ismael Luis; Čepukaitytė, Giedrė; Chiesa, Scott T.; Dawson, Walter D.; Deckers, Kay; De la Cruz-Góngora, Vanessa; Dounavi, Maria-Eleni; Govia, Ishtar (Elsevier, 2024-12-20)

  fforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a ...
• Risk factors and baseline cognition. Preliminary results from the LatAm-FINGERS cohort 

  Corvalán, Nicolás; Keller, Greta; Surace, Ezequiel Ignacio; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Monica; Allegri, Ricardo Francisco; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Sevlever, Gustavo Emilio; Crivelli, Lucía; LatAm-FINGERS Consortium (Wiley, 2024)

  Background LatAm-FINGERS - the first non-pharmacological multicenter randomized clinical trial in Latin America - is a valuable opportunity to study lifestyle in a heterogeneous and multiethnic population exposed to a ...
• Case report: A 50 year-old Down syndrome man exhibiting noAlzheimer’s disease biomarker profile nor cognitiveimpairment. Experience from the Argentine Initiative for theStudy of Down syndrome and Alzheimer’s 

  Clas, Giulia Solange; Pertierr, Lucía; Helou, María Belén; Tapajóz Pereira de Sampaio, Fernanda, Fernanda; Magrath Guimet, Nahuel; Allegri, Ricardo Francisco; Marazita, Mariela; Romorini, Leonardo; Surace, Ezequiel Ignacio (Wiley, 2024)

  Background: Down Syndrome (DS) is the most common genetic form of intellectualdisability. In recent years, there has been a significant increase in the life expectancyof individuals with DS, currently reaching the age of ...
• The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset. 

  Liu, Haiyan; Marsh, Thomas W.; Shi, Xinyu; Renton, Alan E.; Bowling, Kevin M.; Ziegemeier, Ellen; Wang, Guoqiao; Cao, Yuchen; Aristel, Alisha; Li, Jessie; Dickson, Alexa; Perrin, Richard J.; Goate, Alison M.; Fernández, Victoria; Day, Gregory S.; Doering, Michelle; Daniels, Alisha; Supnet-Bell, Charlene; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Oxford University Press, 2025-02-04)

  We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). A total of 550 variants in the APP, PSEN1, and PSEN2 genes were identified, of which 279 were ...
• Exosomal mRNA Signatures as Predictive Biomarkers for Risk and Age of Onset in Alzheimer's Disease 

  Bolívar, Daniel A.; Mosquera Heredia, María I.; Vidal, Oscar M.; Barceló, Ernesto; Allegri, Ricardo Francisco; Morales, Luis C.; Silvera Redondo, Carlos; Arcos Burgos, Mauricio; Garavito Galofre, Pilar; Vélez, Jorge I. (MDPI, 2024-11-15)

  Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. While the precise causes of AD remain unclear, emerging evidence suggests that messenger RNA (mRNA) ...
• Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review 

  Crivelli, Lucía; Winkler, Andrea Sylvia; Keller, Greta; Beretta, Simone; Calandri, Ismael Luis; De Groote, Wouter; Fornari, Arianna; Frontera, Jennifer; Kivipelto, Miia; Lopez-Rocha, Ana Sabsil; Mangialasche, Francesca; Munblit, Daniel; Palmer, Katie; Guekht, Alla; Allegri, Ricardo Francisco (Elsevier, 2025-03)

  Background This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with ...
• Survey among experts on the future role of tau-PET in clinical practice and trials 

  Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley on behalf of the Alzheimer's Association, 2024)

  Background: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the ...
• Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project) 

  Udeh-Momoh, Chinedu T.; Maina, Rachel; Anazodo, Udunna C.; Akinyemi, Rufus; Atwoli, Lukoye; Baker, Laura; Bassil, Darina; Blackmon, Karen; Bosire, Edna; Chemutai, Gloria; Crivelli, Lucía; Ez, Laz U.; Ibanez, Agustin; Kafetsouli, Dimitra; Karikari, Thomas K.; Khakali, Linda; Kumar, Manasi; Lengyel, Imre; de Jager Loots, Celeste A.; Africa‐FINGERS Study Team (John Wiley & Sons, 2024-11-07)

  Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to ...
• Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease 

  Hofmann, Anna; Häsler, Lisa M.; Lambert, Marius; Kaeser, Stephan A.; Gräber-Sultan, Susanne; Obermüller, Ulrike; Kuder-Buletta, Elke; La Fougère, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Fox, Nick C.; Ryan, Natalie S.; Zetterberg, Henrik; Llibre Guerra, Jorge J.; Perrin, Richard J.; Ibanez, Laura; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (Nature Pub. Group, 2024)

  Disease-modifying therapies for Alzheimer's disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, ...
• Brain morphometry in transient global amnesia: a triangulated analysis approach 

  Hernández, Micaela Anahí; Chaves, Hernán; Allegri, Ricardo Francisco; Calandri, Ismael Luis (Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento, 2024)

  Transient global amnesia (TGA) is a rare, temporary, sudden-onset disturbance in anterograde episodic memory with unclear pathophysiology. Previous brain volumetric analysis in TGA patients showed varied results. Objective: ...
• Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation 

  Dubois, Bruno; Villain, Nicolas; Schneider, Lon; Fox, Nick C.; Campbell, Noll; Galasko, Douglas; Kivipelto, Miia; Jessen, Frank; Hanseeuw, Bernard J.; Boada, Mercè; Barkhof, Frederik; Nordberg, Agneta; Froelich, Lutz; Waldemar, Gunhild; Frederiksen, Kristian Steen; Padovani, Alessandro; Planche, Vincent; Rowe, Christopher C.; Bejanin, Alexandre; Allegri, Ricardo Francisco (American Medical Association, 2024-11-01)

  Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer Association (AA) criteria for AD furthers this ...
• Personal social network strengthens adherence to lifestyle changes in individuals with subjective cognitive decline 

  Calandri, Ismael Luis; Ardohain, Carolina; Elgani, Sofia A.; Seminara, Emiliana; Hernández, Micaela Anahí; Ossenkoppele, Rik; Allegri, Ricardo Francisco (Wiley, 2024-11-19)

  Introduction: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice ...

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