• Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis 

  Mosquera Heredia, Maria I.; Vidal, Oscar M.; Morales, Luis C.; Silvera Redondo, Carlos; Barceló, Ernesto; Allegri, Ricardo Francisco; Arcos Burgos, Mauricio; Vélez, Jorge I.; Garavito Galofre, Pilar (MDPI, 2024-07-11)

  Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied ...
• Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation 

  Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco (Elsevier, 2024-09)

  We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem ...
• Perspectives on brain health and dementia prevention in Latin America: challenges and opportunities 

  Fox, Sarah; León, Tomás; Mariano, Luciano; Arshad, Faheem; Magrath Guimet, Nahuel; Hope, Grainne; Tituaña, Kuripacha; Zapata Restrepo, Lina María (Frontiers Media SA, 2023-10-16)

  While age-specific dementia prevalence is falling in many countries, several recent reviews estimate prevalence in Latin America to be higher than anywhere else in the world. This may be, in part, due to the high incidence ...
• Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina 

  Calandri, Ismael Luis; Livingston, Gill; Paradela, Regina; Ossenkoppele, Rik; Crivelli, Lucía; Allegri, Ricardo Francisco; Suemoto, Claudia K. (Karger, 2024-01-31)

  Introduction: Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such factors in middle- and low-income countries. We aimed to estimate the population-attributable ...
• Clinical Manifestations 

  Clarens, María Florencia; Chrem Méndez, Patricio Alexis; Tapajoz, Fernanda; Martinez, Carlos; Helou, María Belén; Surace, Ezequiel Ignacio; Crivelli, Lucía; Romero, Daniela; Vigo, Gabriela; Allegri, Ricardo Francisco (Wiley, 2023-12-25)

  Background: In recent years, there has been an increase in the number of case reports of families with autosomal dominant Alzheimer's disease (ADAD) in Latin America (LA). Nevertheless, little is known about the clinical ...
• Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial 

  Wagemann, Olivia; Liu, Haiyan; Wang, Guoqiao; Shi, Xinyu; Bittner, Tobias; Scelsi, Marzia A.; Farlow, Martin R.; Clifford, David B.; Supnet Bell, Charlene; Santacruz, Anna M.; Aschenbrenner, Andrew J.; Hassenstab, Jason J.; Benzinger, Tammie L.S.; Gordon, Brian A.; Coalier, Kelley A.; Cruchaga, Carlos; Ibanez, Laura; Perrin, Richard J.; Xiong, Chengjie; Li, Yan; Morris, John C.; Lah, James J.; Berman, Sarah B.; Roberson, Erik D.; van Dyck, Christopher H.; Galasko, Douglas; Gauthier, Serge; Hsiung, Ging-Yuek R.; Brooks, William S.; Pariente, Jérémie; Mummery, Catherine J.; Day, Gregory S.; Ringman, John M.; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network–Trials Unit (American Medical Association, 2024-06-01)

  Importance: Effects of antiamyloid agents, targeting either fibrillar or soluble monomeric amyloid peptides, on downstream biomarkers in cerebrospinal fluid (CSF) and plasma are largely unknown in dominantly inherited ...
• Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City 

  Sosa, Ana Luisa; Brucki, Sonia M.; Crivelli, Lucía; Lopera, Francisco Javier; Acosta, Daisy M.; Acosta Uribe, Juliana; Aguilar, Diego; Aguilar Navarro, Sara G.; Allegri, Ricardo Francisco; Bertolucci, Paulo H.; Calandri, Ismael Luis; Carrillo, María C.; Chrem Méndez, Patricio Alexis; Cornejo Olivas, Mario; Custodio, Nilton; Damián, Andrés; Cruz de Souza, Leonardo; Duran Aniotz, Claudia; García, Adolfo M.; Sevlever, Gustavo Emilio (John Wiley & Sons, 2024-05-27)

  Introduction: While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care. Methods: In 2023, ...
• Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset 

  Galvin, James E.; Cummings, Jeffrey L.; Levitchi Benea, Mihaela; de Moor, Carl; Allegri, Ricardo Francisco; Atri, Alireza; Chertkow, Howard; Paquet, Claire; Porter, Verna R.; Ritchie, Craig W.; Sikkes, Sikkes A.M.; Smith, Michael R.; Grassi, Christina Marsica; Rubino, Ivana (John Wiley & Sons, Ltd., 2024-05-06)

  Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes ...
• The impact of reward and punishment sensitivity on memory and executive performance in individuals with amnestic mild cognitive impairment 

  Corvalán, Nicolás; Crivelli, Lucía; Allegri, Ricardo Francisco; Pedreira, Maria E.; Fernández, Rodrigo S. (Elsevier/North-Holland Biomedical Pres, 2024-06-10)

  Amnestic mild cognitive impairment (aMCI) is defined by memory impairment but executive function (EF) deficits could be also a common feature. This study examined the underlying neurocognitive processes associated with ...
• Qué es un banco de cerebros 

  Sevlever, Gustavo Emilio (Polemos, 2023)

  Capítulo 17 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• Difundir la prevención a la comunidad: llegar antes 

  Canevaro, Lilia; Bagnati, Pablo M. (Polemos, 2023)

  Capítulo 14 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• Tratamientos en demencias 

  Bagnati, Pablo M.; Kremer, Janus; Waisman Campos, Marcela (Polemos, 2023)

  Capítulo 12 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• Conducción de automóviles y demencia 

  Bagnati, Pablo M.; Sambade, Silvia (Polemos, 2023)

  Capítulo 11 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• ¿Por qué muere un paciente con Alzheimer? Complicaciones médicas y neurológicas en la progresión de la demencia 

  Cohen, Gabriela; Campos, Jorge (Polemos, 2023)

  Capítulo 10 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• ¿Qué riesgo tengo de heredar la enfermedad de Alzheimer? Genética y demencias 

  Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio (Polemos, 2023)

  Capítulo 7 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• ¿Qué es la demencia? 

  Bagnati, Pablo M. (Polemos, 2023)

  Introducción de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• Trastornos de conducta en la enfermedad de Alzheimer 

  Magrath Guimet, Nahuel; Herrera, Julio José; Fernández, María Laura (Polemos, 2023)

  Capítulo 4 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• Olvidos: ¿normal envejecimiento o síntomas de enfermedad? 

  Castro, Diego M.; Allegri, Ricardo Francisco (Polemos, 2023)

  Capítulo 2 de "Enfermedad de Alzheimer y otras demencias: manual para la familia"
• Enfermedad de Alzheimer y otras demencias : manual para la familia 

  Bagnati, Pablo M. (Polemos, 2023)

  Resumen no disponible
• Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease. 

  Iaccarino, Leonardo; Llibre Guerra, Jorge J.; McDade, Eric; Edwards, Lauren; Gordon, Brian A.; Benzinger, Tammie L.S.; Hassenstab, Jason; Kramer, Joel H.; Li, Yan; Miller, Bruce L.; Miller, Zachary; Morris, John C.; Mundada, Nidhi; Perrin, Richard J.; Rosen, Howard J.; Soleimani Meigooni, David; Strom, Amelia; Tsoy, Elena; Wang, Guoqiao; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Vázquez, Silvia (Oxford University Press, 2024-05-03)

  Approximately 5% of Alzheimer's disease patients develop symptoms before age 65 (early-onset Alzheimer's disease), with either sporadic (sporadic early-onset Alzheimer's disease) or dominantly inherited (dominantly inherited ...

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