• Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations 

  Farina, Francesca R.; Bridgeman, Katie; Gregory, Sarah; Crivelli, Lucía; Foote, Isabelle F.; Jutila, Otto-Emil I.; Kucikova, Ludmila; Mariano, Luciano I.; Nguyen, Kim-Huong; Thayanandan, Tony; Akindejoye, Funmi; Butler, Joe; Calandri, Ismael Luis; Čepukaitytė, Giedrė; Chiesa, Scott T.; Dawson, Walter D.; Deckers, Kay; De la Cruz-Góngora, Vanessa; Dounavi, Maria-Eleni; Govia, Ishtar (Elsevier, 2024-12-20)

  fforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a ...
• The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset. 

  Liu, Haiyan; Marsh, Thomas W.; Shi, Xinyu; Renton, Alan E.; Bowling, Kevin M.; Ziegemeier, Ellen; Wang, Guoqiao; Cao, Yuchen; Aristel, Alisha; Li, Jessie; Dickson, Alexa; Perrin, Richard J.; Goate, Alison M.; Fernández, Victoria; Day, Gregory S.; Doering, Michelle; Daniels, Alisha; Supnet-Bell, Charlene; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Oxford University Press, 2025-02-04)

  We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). A total of 550 variants in the APP, PSEN1, and PSEN2 genes were identified, of which 279 were ...
• Exosomal mRNA Signatures as Predictive Biomarkers for Risk and Age of Onset in Alzheimer's Disease 

  Bolívar, Daniel A.; Mosquera Heredia, María I.; Vidal, Oscar M.; Barceló, Ernesto; Allegri, Ricardo Francisco; Morales, Luis C.; Silvera Redondo, Carlos; Arcos Burgos, Mauricio; Garavito Galofre, Pilar; Vélez, Jorge I. (MDPI, 2024-11-15)

  Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. While the precise causes of AD remain unclear, emerging evidence suggests that messenger RNA (mRNA) ...
• Impact of COVID-19 on functional, cognitive, neuropsychiatric, and health-related outcomes in patients with dementia: A systematic review 

  Crivelli, Lucía; Winkler, Andrea Sylvia; Keller, Greta; Beretta, Simone; Calandri, Ismael Luis; De Groote, Wouter; Fornari, Arianna; Frontera, Jennifer; Kivipelto, Miia; Lopez-Rocha, Ana Sabsil; Mangialasche, Francesca; Munblit, Daniel; Palmer, Katie; Guekht, Alla; Allegri, Ricardo Francisco (Elsevier, 2025-03)

  Background This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with ...
• Survey among experts on the future role of tau-PET in clinical practice and trials 

  Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (Wiley on behalf of the Alzheimer's Association, 2024)

  Background: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the ...
• Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project) 

  Udeh-Momoh, Chinedu T.; Maina, Rachel; Anazodo, Udunna C.; Akinyemi, Rufus; Atwoli, Lukoye; Baker, Laura; Bassil, Darina; Blackmon, Karen; Bosire, Edna; Chemutai, Gloria; Crivelli, Lucía; Ez, Laz U.; Ibanez, Agustin; Kafetsouli, Dimitra; Karikari, Thomas K.; Khakali, Linda; Kumar, Manasi; Lengyel, Imre; de Jager Loots, Celeste A.; Africa‐FINGERS Study Team (John Wiley & Sons, 2024-11-07)

  Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to ...
• Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease 

  Hofmann, Anna; Häsler, Lisa M.; Lambert, Marius; Kaeser, Stephan A.; Gräber-Sultan, Susanne; Obermüller, Ulrike; Kuder-Buletta, Elke; La Fougère, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Fox, Nick C.; Ryan, Natalie S.; Zetterberg, Henrik; Llibre Guerra, Jorge J.; Perrin, Richard J.; Ibanez, Laura; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (Nature Pub. Group, 2024)

  Disease-modifying therapies for Alzheimer's disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, ...
• Brain morphometry in transient global amnesia: a triangulated analysis approach 

  Hernández, Micaela Anahí; Chaves, Hernán; Allegri, Ricardo Francisco; Calandri, Ismael Luis (Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento, 2024)

  Transient global amnesia (TGA) is a rare, temporary, sudden-onset disturbance in anterograde episodic memory with unclear pathophysiology. Previous brain volumetric analysis in TGA patients showed varied results. Objective: ...
• Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation 

  Dubois, Bruno; Villain, Nicolas; Schneider, Lon; Fox, Nick C.; Campbell, Noll; Galasko, Douglas; Kivipelto, Miia; Jessen, Frank; Hanseeuw, Bernard J.; Boada, Mercè; Barkhof, Frederik; Nordberg, Agneta; Froelich, Lutz; Waldemar, Gunhild; Frederiksen, Kristian Steen; Padovani, Alessandro; Planche, Vincent; Rowe, Christopher C.; Bejanin, Alexandre; Allegri, Ricardo Francisco (American Medical Association, 2024-11-01)

  Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer Association (AA) criteria for AD furthers this ...
• Personal social network strengthens adherence to lifestyle changes in individuals with subjective cognitive decline 

  Calandri, Ismael Luis; Ardohain, Carolina; Elgani, Sofia A.; Seminara, Emiliana; Hernández, Micaela Anahí; Ossenkoppele, Rik; Allegri, Ricardo Francisco (Wiley, 2024-11-19)

  Introduction: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice ...
• Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the US POINTER Trial 

  Espeland, Mark A.; Demesie, Yitbarek N.; Olson, Kay Loni; Lockhart, Samuel N.; Tomaszewski Farias, Sarah E.; Cleveland, Maryjo L.; Tangney, Christy C.; Crivelli, Lucía; Snyder, Heather M.; York, Michele K.; Baker, Laura; Whitmer, Rachel A.; Wing, Rena R.; Garcia, Katelyn R.; Callahan, Kathryn E.; U.S. POINTER Research Group (Oxford University, 2024-11-16)

  Background: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty ...
• CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease 

  Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John P.; Do, Anh; Liu, Haiyan; Gordon, Brian A.; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)

  In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
• Insights into the use of biomarkers in clinical trials in Alzheimer's disease 

  Pascoal, Tharick A.; Aguzzoli, Cristiano S.; Lussier, Firoza Z.; Crivelli, Lucía; Suemoto, Claudia Kimie; Fortea, Juan; Rosa Neto, Pedro; Zimmer, Eduardo R.; Ferreira, Pamela C. L.; Bellaver, Bruna (Elsevier, 2024-10-03)

  Biomarkers have been instrumental in population selection and disease monitoring in clinical trials of recently FDA-approved drugs targeting amyloid-β to slow the progression of Alzheimer's disease (AD). As new therapeutic ...
• Comparative accuracy of Mini-Linguistic State Examination, Addenbrooke's Cognitive Examination, and Depistage Cognitif de Quebec for the diagnosis of primary progressive aphasia 

  Fernández Romero, Lucía; Morello García, Florentina; Laforce Jr, Robert; Delgado Alonso, Cristina; Delgado Álvarez, Alfonso; Gil Moreno, María José; Lavoie, Monica; Cuetos, Fernando; Matias Guiu, Jordi A.; Matias Guiu, Jorge (SAGE, 2024-10-17)

  Background: Clinical diagnosis in primary progressive aphasia (PPA) is challenging. Recently, emphasis has been placed on the importance of screening evaluation. Three different screening tests that use different strategies ...
• Need to adapt Alzheimer's disease criteria in Latin America. 

  Custodio, Nilton; Allegri, Ricardo Francisco; Lopera, Francisco; Caramelli, Paulo (John Wiley & Sons, 2024-10-06)
• Argentina-Alzheimer's Disease Neuroimaging Initiative: pioneering Alzheimer's Research in Latin America and its Implications for Regional Advancement 

  Cubas Guillen, Jonathan Fernando; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Martin, María Eugenia; Clarens, María Florencia; Russo, María Julieta; Harris, Paula; Egido, Noelia; Tapajóz Pereira de Sampaio, Fernanda; Chaves, Hernán; Vázquez, Silvia; Martinetto, Horacio; Campos, Jorge; Calandri, Ismael Luis; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (John Wiley & Sons, 2024-10-06)

  The Alzheimer's Disease Neuroimaging Initiative (ADNI) has fostered collaboration among researchers around the world, catalyzing innovation and accelerating progress in the field. In Latin America, this initiative advanced ...
• Axonal damage and inflammation response are biological correlates of decline in small-world values: a cohort study in autosomal dominant Alzheimer's disease 

  Vermunt, Lisa; Sutphen, Courtney L.; Dicks, Ellen; de Leeuw, Diederick M.; Allegri, Ricardo Francisco; Berman, Sarah B.; Cash, David M.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Day, Gregory S.; Ewers, Michael; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Graff-Radford, Neill R.; Hassenstab, Jason; Jucker, Mathias; Karch, Celeste M.; Kuhle, Jens; Laske, Christoph (Oxford University Press, 2024-10-09)

  The grey matter of the brain develops and declines in coordinated patterns during the lifespan. Such covariation patterns of grey matter structure can be quantified as grey matter networks, which can be measured with ...
• Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease 

  Sewell, Kelsey R.; Doecke, James D.; Xiong, Chengjie; Benzinger, Tammie L.S.; Masters, Colin L.; Laske, Christoph; Jucker, Mathias; Lopera, Francisco; Gordon, Brian A.; Llibre Guerra, Jorge J.; Levin, Johannes; Huey, Edward D.; Hassenstab, Jason; Schofield, Peter R.; Day, Gregory S.; Fox, Nick C.; Chhatwal, Jasmeer P.; Ibanez, Laura; Roh, Jee Hoon; Perrin, Richard J.; Lee, Jae-Hong; Allegri, Ricardo Francisco; Supnet Bell, Charlene; Berman, Sarah B.; Daniels, Alisha; Noble, James M.; Martins, Ralph N.; Rainey-Smith, Stephanie; Peiffer, Jeremiah; Gardener, Samantha L.; Bateman, Randall J.; Morris, John C.; McDade, Eric; Erickson, Kirk I.; Sohrabi, Hamid R.; Brown, Belinda M.; Dominantly Inherited Alzheimer Network (Wiley, 2024-09-26)

  Introduction: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. Methods: Participants ...
• Population attributable fractions for risk factors for dementia in seven Latin American countries: an analysis using cross-sectional survey data 

  Paradela, Regina Silva; Calandri, Ismael Luis; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; Crivelli, Lucía; Yaffe, Kristine; Cleusa P Ferri, Cleusa P.; Mukadam, Naaheed; Livingston, Gill; Suemoto, Claudia Kimie (Elsevier, 2024-10)

  Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine ...
• Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis 

  Mosquera Heredia, Maria I.; Vidal, Oscar M.; Morales, Luis C.; Silvera Redondo, Carlos; Barceló Martínez, Ernesto; Allegri, Ricardo Francisco; Arcos Burgos, Mauricio; Vélez, Jorge I.; Garavito Galofre, Pilar (MDPI, 2024-07-11)

  Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied ...

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