• Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation 

  Dubois, Bruno; Villain, Nicolas; Schneider, Lon; Fox, Nick; Campbell, Noll; Galasko, Douglas; Kivipelto, Miia; Jessen, Frank; Hanseeuw, Bernard; Boada, Mercè; Barkhof, Frederik; Nordberg, Agneta; Froelich, Lutz; Waldemar, Gunhild; Frederiksen, Kristian Steen; Padovani, Alessandro; Planche, Vincent; Rowe, Christopher; Bejanin, Alexandre; Allegri, Ricardo Francisco (American Medical Association, 2024-11-01)

  Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer Association (AA) criteria for AD furthers this ...
• Personal social network strengthens adherence to lifestyle changes in individuals with subjective cognitive decline 

  Calandri, Ismael Luis; Ardohain, Carolina; Elgani, Sofia A.; Seminara, Emiliana; Hernandez, Micaela Anahí; Ossenkoppele, Rik; Allegri, Ricardo Francisco (Wiley, 2024-11-19)

  Introduction: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice ...
• Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the US POINTER Trial 

  Espeland, Mark A.; Demesie, Yitbarek N.; Olson, Kay Loni; Lockhart, Samuel N.; Tomaszewski Farias, Sarah E.; Cleveland, Maryjo L.; Tangney, Christy C.; Crivelli, Lucía; Snyder, Heather M.; York, Michele K.; Baker, Laura D.; Whitmer, Rachel A.; Wing, Rena R.; Garcia, Katelyn R.; Callahan, Kathryn E.; U.S. POINTER Research Group (Oxford University, 2024-11-16)

  Background: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty ...
• CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease 

  Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John; Do, Anh; Liu, Haiyan; Gordon, Brian; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)

  In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
• Insights into the use of biomarkers in clinical trials in Alzheimer's disease 

  Pascoal, Tharick A.; Aguzzoli, Cristiano S.; Lussier, Firoza Z.; Crivelli, Lucía; Suemoto, Claudia K.; Fortea, Juan; Rosa Neto, Pedro; Zimmer, Eduardo R.; Ferreira, Pamela C. L.; Bellaver, Bruna (Elsevier, 2024-10-03)

  Biomarkers have been instrumental in population selection and disease monitoring in clinical trials of recently FDA-approved drugs targeting amyloid-β to slow the progression of Alzheimer's disease (AD). As new therapeutic ...
• Comparative accuracy of Mini-Linguistic State Examination, Addenbrooke's Cognitive Examination, and Depistage Cognitif de Quebec for the diagnosis of primary progressive aphasia 

  Fernández Romero, Lucía; Morello García, Florentina; Laforce Jr, Robert; Delgado Alonso, Cristina; Delgado Álvarez, Alfonso; Gil Moreno, María José; Lavoie, Monica; Cuetos, Fernando; Matias Guiu, Jordi A.; Matias Guiu, Jorge (SAGE, 2024-10-17)

  Background: Clinical diagnosis in primary progressive aphasia (PPA) is challenging. Recently, emphasis has been placed on the importance of screening evaluation. Three different screening tests that use different strategies ...
• Need to adapt Alzheimer's disease criteria in Latin America. 

  Custodio, Nilton; Allegri, Ricardo Francisco; Lopera, Francisco; Caramelli, Paulo (John Wiley & Sons, 2024-10-06)
• Argentina-Alzheimer's Disease Neuroimaging Initiative: pioneering Alzheimer's Research in Latin America and its Implications for Regional Advancement 

  Cubas Guillen, Jonathan Fernando; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Martin, María Eugenia; Clarens, María Florencia; Russo, María Julieta; Harris, Paula; Egido, Noelia; Tapajóz Pereira de Sampaio, Fernanda; Chaves, Hernán; Vázquez, Silvia; Martinetto, Horacio; Campos, Jorge; Calandri, Ismael Luis; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (John Wiley & Sons, 2024-10-06)

  The Alzheimer's Disease Neuroimaging Initiative (ADNI) has fostered collaboration among researchers around the world, catalyzing innovation and accelerating progress in the field. In Latin America, this initiative advanced ...
• Axonal damage and inflammation response are biological correlates of decline in small-world values: a cohort study in autosomal dominant Alzheimer's disease 

  Vermunt, Lisa; Sutphen, Courtney L.; Dicks, Ellen; de Leeuw, Diederick M.; Allegri, Ricardo Francisco; Berman, Sarah B.; Cash, David M.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Day, Gregory S.; Ewers, Michael; Farlow, Martin R.; Fox, Nick C.; Ghetti, Bernardino; Graff-Radford, Neill R.; Hassenstab, Jason; Jucker, Mathias; Karch, Celeste M.; Kuhle, Jens; Laske, Christoph (Oxford University Press, 2024-10-09)

  The grey matter of the brain develops and declines in coordinated patterns during the lifespan. Such covariation patterns of grey matter structure can be quantified as grey matter networks, which can be measured with ...
• Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease 

  Sewell, Kelsey R.; Doecke, James D.; Xiong, Chengjie; Benzinger, Tammie; Masters, Colin L.; Laske, Christoph; Jucker, Mathias; Lopera, Francisco; Gordon, Brian A.; Llibre-Guerra, Jorge; Levin, Johannes; Huey, Edward D.; Hassenstab, Jason; Schofield, Peter R.; Day, Gregory S.; Fox, Nick C.; Chhatwal, Jasmeer; Ibanez, Laura; Roh, Jee Hoon; Perrin, Richard; Lee, Jae-Hong; Allegri, Ricardo Francisco; Supnet-Bell, Charlene; Berman, Sarah B.; Daniels, Alisha; Noble, James; Martins, Ralph N.; Rainey-Smith, Stephanie; Peiffer, Jeremiah; Gardener, Samantha L.; Bateman, Randall J.; Morris, John C.; McDade, Eric; Erickson, Kirk I.; Sohrabi, Hamid R.; Brown, Belinda M.; Dominantly Inherited Alzheimer's Network (Wiley, 2024-09-26)

  Introduction: We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. Methods: Participants ...
• Population attributable fractions for risk factors for dementia in seven Latin American countries: an analysis using cross-sectional survey data 

  Paradela, Regina Silva; Calandri, Ismael Luis; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; Crivelli, Lucìa; Yaffe, Kristine; Cleusa P Ferri, Cleusa P.; Mukadam, Naaheed; Livingston, Gill; Suemoto, Claudia Kimie (Elsevier, 2024-10)

  Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine ...
• Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis 

  Mosquera Heredia, Maria I.; Vidal, Oscar M.; Morales, Luis C.; Silvera Redondo, Carlos; Barceló, Ernesto; Allegri, Ricardo Francisco; Arcos Burgos, Mauricio; Vélez, Jorge I.; Garavito Galofre, Pilar (MDPI, 2024-07-11)

  Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied ...
• Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation 

  Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco (Elsevier, 2024-09)

  We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem ...
• Perspectives on brain health and dementia prevention in Latin America: challenges and opportunities 

  Fox, Sarah; León, Tomás; Mariano, Luciano; Arshad, Faheem; Magrath Guimet, Nahuel; Hope, Grainne; Tituaña, Kuripacha; Zapata Restrepo, Lina María (Frontiers Media SA, 2023-10-16)

  While age-specific dementia prevalence is falling in many countries, several recent reviews estimate prevalence in Latin America to be higher than anywhere else in the world. This may be, in part, due to the high incidence ...
• Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina 

  Calandri, Ismael Luis; Livingston, Gill; Paradela, Regina; Ossenkoppele, Rik; Crivelli, Lucía; Allegri, Ricardo Francisco; Suemoto, Claudia K. (Karger, 2024-01-31)

  Introduction: Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such factors in middle- and low-income countries. We aimed to estimate the population-attributable ...
• Clinical Manifestations 

  Clarens, María Florencia; Chrem Méndez, Patricio Alexis; Tapajoz, Fernanda; Martinez, Carlos; Helou, María Belén; Surace, Ezequiel Ignacio; Crivelli, Lucía; Romero, Daniela; Vigo, Gabriela; Allegri, Ricardo Francisco (Wiley, 2023-12-25)

  Background: In recent years, there has been an increase in the number of case reports of families with autosomal dominant Alzheimer's disease (ADAD) in Latin America (LA). Nevertheless, little is known about the clinical ...
• Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial 

  Wagemann, Olivia; Liu, Haiyan; Wang, Guoqiao; Shi, Xinyu; Bittner, Tobias; Scelsi, Marzia A.; Farlow, Martin R.; Clifford, David B.; Supnet Bell, Charlene; Santacruz, Anna M.; Aschenbrenner, Andrew J.; Hassenstab, Jason J.; Benzinger, Tammie L.S.; Gordon, Brian A.; Coalier, Kelley A.; Cruchaga, Carlos; Ibanez, Laura; Perrin, Richard J.; Xiong, Chengjie; Li, Yan; Morris, John C.; Lah, James J.; Berman, Sarah B.; Roberson, Erik D.; van Dyck, Christopher H.; Galasko, Douglas; Gauthier, Serge; Hsiung, Ging-Yuek R.; Brooks, William S.; Pariente, Jérémie; Mummery, Catherine J.; Day, Gregory S.; Ringman, John M.; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network–Trials Unit (American Medical Association, 2024-06-01)

  Importance: Effects of antiamyloid agents, targeting either fibrillar or soluble monomeric amyloid peptides, on downstream biomarkers in cerebrospinal fluid (CSF) and plasma are largely unknown in dominantly inherited ...
• Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City 

  Sosa, Ana Luisa; Brucki, Sonia M.; Crivelli, Lucía; Lopera, Francisco Javier; Acosta, Daisy M.; Acosta Uribe, Juliana; Aguilar, Diego; Aguilar Navarro, Sara G.; Allegri, Ricardo Francisco; Bertolucci, Paulo H.; Calandri, Ismael Luis; Carrillo, María C.; Chrem Méndez, Patricio Alexis; Cornejo Olivas, Mario; Custodio, Nilton; Damián, Andrés; Cruz de Souza, Leonardo; Duran Aniotz, Claudia; García, Adolfo M.; Sevlever, Gustavo Emilio (John Wiley & Sons, 2024-05-27)

  Introduction: While Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care. Methods: In 2023, ...
• Generating real-world evidence in Alzheimer's disease: Considerations for establishing a core dataset 

  Galvin, James E.; Cummings, Jeffrey L.; Levitchi Benea, Mihaela; de Moor, Carl; Allegri, Ricardo Francisco; Atri, Alireza; Chertkow, Howard; Paquet, Claire; Porter, Verna R.; Ritchie, Craig W.; Sikkes, Sikkes A.M.; Smith, Michael R.; Grassi, Christina Marsica; Rubino, Ivana (John Wiley & Sons, Ltd., 2024-05-06)

  Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real-world treatment effectiveness and safety. However, interpreting outcomes ...
• The impact of reward and punishment sensitivity on memory and executive performance in individuals with amnestic mild cognitive impairment 

  Corvalán, Nicolás; Crivelli, Lucía; Allegri, Ricardo Francisco; Pedreira, Maria E.; Fernández, Rodrigo S. (Elsevier/North-Holland Biomedical Pres, 2024-06-10)

  Amnestic mild cognitive impairment (aMCI) is defined by memory impairment but executive function (EF) deficits could be also a common feature. This study examined the underlying neurocognitive processes associated with ...

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