Neurología Cognitiva.artículos: Envíos recientes

  • Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study 
    Patel, Maulikkumar; Feng, Wei; McKay, Nicole S.; Millar, Peter R.; Liu, Menghan; Yang, Chengran; Cetin, Arda; Johnson, Matthew; Budde, John P.; Western, Daniel; Marsh, Thomas W.; Saliu, Ibrahim O.; Gordon, Brian A.; Llibre Guerra, Jorge J.; Morris, John C.; Bateman, Randall J.; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Vázquez, Silvia (Lancet, 2026-06)
    Background: Individuals with autosomal dominant Alzheimer's disease (ADAD) arising from mutations in PSEN1, PSEN2, or APP exhibit variability in clinical presentation. Genetic studies of ADAD have shaped our understanding ...
  • Conmociones cerebrales en el fútbol: avances recientes y desafíos en la gestión clínica y preventiva 
    Russo, María Julieta; Salvat, Fernando; Ameriso, Sebastián Francisco; Villani, Donato; Vega, Jorge; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio (Fundación Revista Medicina (Buenos Aires), 2026-08)
    Concussions in soccer are a key challenge for neurological health due to their high incidence, diagnostic complexity, and risk of long-term sequelae. This article provides a narrative review of their definition, epidemiology, ...
  • Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease 
    Morcillo Nieto, Alejandra O.; Franquesa Mullerat, Maria; Zsadanyi, Sara E.; Arriola‐Infante, José Enrique; Vaqué‐Alcázar, Lídia; Rozalem Aranha, Mateus; Allende Parra, José; Zhao, Zili; Arranz, Javier; Rodríguez‐Baz, Íñigo; Maure Blesa, Lucia; Videla, Laura; Barroeta, Isabel; Del Hoyo Soriano, Laura; Benejam, Bessy; Fernández, Susana; Sanjuan Hernandez, Aida; Pertierra, Lucía; Giménez, Sandra; Santos Santos, Miguel Ángel (Wiley, 2026-05-29)
    INTRODUCTION: This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker ...
  • Recommendations for genetic counseling for individuals at risk of autosomal dominant Alzheimer's disease in Latin America 
    Jiménez, Daniel A.; Bagnati, Pablo M.; Flores Montes, Rosa Elena; Fernández, María Laura; Zuno Reyes, Angélica; Aguillón, David; Aláez Versón, Carmen; Becerra Solano, Luis Eduardo; Behrens, María Isabel; Branda, Kelly; Chrem Méndez, Patricio Alexis; Custodio, Nilton; Ducaine, Whitney; Dumois Petersen, Sofía; Figuera, Luis; Londoño Castaño, Marisol; Longoria, Erika Mariana; Matute, Esmeralda; Surace, Ezequiel Ignacio; Programa de asesoramiento genético en América Latina (PRAGA) (Wiley, 2026-05-27)
    Autosomal dominant Alzheimer's disease (ADAD) represents a small but impactful subset of Alzheimer's cases. Asymptomatic individuals at genetic risk face substantial personal and family implications when considering ...
  • Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome 
    Giménez, Sandra; Vaqué-Alcázar, Lídia; Clos, Susana; Benejam, Bessy; Carmona-Iragui, María; Maure Blesa, Lucia; Videla, Laura; Zhu, Nuole; Altuna, Miren; Arranz, Javier; Barroeta, Isabel; Rodríguez-Baz, Íñigo; Bejanin, Alexandre; Bueno, Ana; Fernández, Susana; Del Hoyo Soriano, Laura; Pertierra, Lucía; Alcolea, Daniel; Miller, Bruce; Grinberg, Lea T. (Wiley, 2026-05)
    Introduction: Sleep and circadian rest-activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR ...
  • Regression-based normative data for neuropsychological assessment in Buenos Aires, Argentina: RAVLT, trail making test, digit span, and verbal fluency 
    Corvalán, Nicolás; Morello García, Florentina; Leiva, Samanta; Allegri, Ricardo Francisco; Crivelli, Lucía (Cambridge University Press, 2026-05-11)
    Objective: To develop regression-based normative data for a set of widely used neuropsychological tests and to provide a freely accessible normative data calculator for use in Buenos Aires, Argentina. Methods: Participants ...
  • Can Yerba Mate Reduce the Risk of Cognitive Impairment? A pilot study 
    Gilbert, Afra; Gatto, Emilia M.; Chocobar, Nicolas; Seguí, Josefina; Crotti, Beatriz; Cubas Guillen, Jonathan Fernando; Merchan del Hierro, Xavier; Bacigalupe, Lucia; Persi, Gabriel; Melcon, Carlos Mario; O'Neill, Santiago; Múnera Martínez, Claudia Patricia; Sierra Sanjurjo, Natalia; Rojas, Galeno J.; Tribbia,Teresita Liliana; Taravini, Irene (Wiley, 2025-12-23)
    Background: Yerba mate (YM), an infusion made from Ilex paraguariensis, is widely consumed in Argentina and other South American countries. Experimental studies have shown that YM enhances antioxidant defenses, increases ...
  • Baseline Results Investigate APOE‐Memory Connection in Latin‐American Population at Risk for Dementia ‐ LatAm‐FINGERS Initial Insights 
    Vasconcelos Friedlaender, Clarisse; Cruz de Souza, Leonardo; Tonidandel Barbosa, Maira; Braga Gomes, Karina; Gonçalves Tosatti, Jéssica Abdo; de Faria Rocha, João Victor; Melillo Cardoso, Davi; Machado Prates, Marcelo; Lopes, Andre Luis; Silva Vieira, Vitoria; Ribeiro Jeunon, Vinicius; Ferreira de Souza, Letícia Maria; Soares Figueiredo, Lais; Andrades, Andreia; Crivelli, Lucía; Calandri, Ismael Luis; Martin, Maria Eugenia; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio (Wiley, 2025-12-21)
    Background: Latin America (LA) faces heightened vulnerability to modifiable dementia risk factors. Early identification of at‐risk individuals is crucial for implementing effective preventive strategies. The Free and Cued ...
  • Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains 
    Pucinelli de Souza Queiroz, Andréia; Pozzolo Pedro, Maria Olivia; Waisman Campos, Marcela; Torales, Julio; Ventriglio, Antonio; Castaldelli-Maia, João Mauricio (MDPI, 2025-07-15)
    Cannabis is the most widely consumed illicit substance worldwide, with rising use particularly among adolescents and young adults. Accumulating evidence indicates that chronic cannabis use may negatively impact several ...
  • Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome 
    Morcillo Nieto, Alejandra O.; Rozalem Aranha, Mateus; Maure Blesa, Lucia; Rodríguez-Baz, Íñigo; Arriola-Infante, José Enrique; Franquesa Mullerat, Maria; Zsadanyi, Sara E.; Vaqué-Alcázar, Lídia; Allende Parra, José; Zhao, Zili; Arranz, Javier; Videla, Laura; Barroeta, Isabel; Del Hoyo Soriano, Laura; Benejam, Bessy; Fernández, Susana; Sanjuan Hernandez, Aida; Pertierra, Lucía; Giménez, Sandra; Alcolea, Daniel (Wiley, 2026-02)
    Introduction: White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. Methods: Longitudinal MRI study, including ...
  • Teleneuropsychology in Latin America: Experiences and challenges during the COVID-19 pandemic 
    Olavarría, Loreto; Dechent, Claudia; Parra Rodriguez, Mario Alfredo; Crivelli, Lucía; Custodio Capuñay, Nilton Santos; Dozzi Brucki, Sonia María; Okada de Oliveira, Maira; Robert, Phillip; Quiroz, Yakeel T.; Antivilo Bruna, Andrés; Arboleda Ramírez, Alejandra; Lillo, Patricia; Carello, María Agostina; Torralba, Teresa; Ramos, Teresita; Duran Aniotz, Claudia; Allegri, Ricardo Francisco; Slachevsky, Andrea (Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento, 2026-03-06)
    La pandemia de COVID-19 aceleró el uso de la teleneuropsicología (TeleNP) para ofrecer servicios neuropsicológicos remotos en entornos con acceso limitado a clínicas. Objetivo: Examinar las prácticas de TeleNP en América ...
  • Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial 
    McCullough, Austin; Chen, Charles D.; Gordon, Brian A.; Joseph-Mathurin, Nelly; Jack Jr, Clifford R; Koeppe, Robert; Hornbeck, Russ; Koudelis, Deborah; McKay, Nicole S.; Hobbs, Diana A.; Flores, Shaney; Keefe, Sarah J.; Aggarwal, Neelum T.; Allegri, Ricardo Francisco; Berman, Sarah B.; Bird, Thomas; Black, Sandra E.; Brooks, William S.; Chhatwal, Jasmeer P.; Day, Gregory S.; DIAN‐TU Study Team (Wiley, 2025-07)
    Introduction: Monoclonal anti-amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose ...
  • Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease 
    Llibre Guerra, Jorge J.; Lu, Ruijin; Clarens, María Florencia; Liu, Ian; Renton, Alan E.; Ryan, Natalie S.; Goate, Alison M.; Aguillón, David; Allegri, Ricardo Francisco; Benzinger, Tammie L.S.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Vigo, Gabriela; Cruchaga, Carlos; Day, Gregory S.; Farlow, Martin R.; Fox, Nick C.; Gordon, Brian A.; Hassenstab, Jason (Lippincott Williams & Wilkins, 2026-04-28)
    Background and objectives: Cognitive reserve has been shown to modulate the onset and progression of Alzheimer disease (AD) symptoms. Although its role in sporadic AD is well-studied, how cognitive reserve influences the ...
  • Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic 
    Groot, Colin; Calandri, Ismael Luis; Bader, Ilse; Bocancea, Diana I.; de Bruin, Hannah; Carrigan, Maria; Collij, Lyduine E.; Duits, Flora H.; Kamps, Suzie; de Koning, Lotte A.; Lemstra, Afina W.; Mastenbroek, Sophie E.; Rikken, Roos M.; van Tol, Bastiaan G. J.; Vermeiren, Marie R.; Wesseling, Alex; Xia, Ye; Teunissen, Charlotte E.; van de Giessen, Elsmarieke; Barkhof, Frederik (Lippincott Williams & Wilkins, 2026-05-12)
    Background and objectives: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, ...
  • The ICN-UN Battery: A Machine Learning-Optimized Tool for Expeditious Alzheimer's Disease Diagnosis 
    Barceló, Ernesto; Romero, Duban; Allegri, Ricardo Francisco; Meza, Eliana; Mosquera-Heredia, María I.; Vidal, Oscar M.; Silvera-Redondo, Carlos; Arcos-Burgos, Mauricio; Garavito-Galofre, Pilar; Vélez, Jorge I. (MDPI AG, 2025-11-28)
    Background/Objectives: Alzheimer's disease (AD) accounts for ~70% of global dementia cases, with projections estimating 139 million affected individuals by 2050. This increasing burden highlights the urgent need for ...
  • Relative impact of multidomain lifestyle interventions on deficit accumulation frailty over 24 months in the U.S. POINTER trial 
    Espeland, Mark A.; Olson, Kay Loni; Tangney, Christy C.; Gitelman, Darren R.; Cleveland, Maryjo L.; Thro, Amber A.; Demesie, Yitbarek N.; Snyder, Heather M.; Whitmer, Rachel A.; Desai, Pankaja; Alam, Rifat; Crivelli, Lucía; Holland, Thomas M.; Preissle, Olivia; Raman, Rema; York, Michele K.; Baker, Laura; U.S. POINTER Study Group (Oxford University Press, 2026-05)
    Background: Multidomain lifestyle interventions hold promise as approaches to slow aging. Deficit accumulation frailty indices (FIs) are increasingly used to capture aging processes. Frailty is highly associated with ...
  • Delphi consensus guidelines for the use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy for the diagnosis of dementia and mild cognitive impairment with Lewy bodies 
    Donaghy, Paul C.; Greenfinch, Gemma; Petrides, George; Kane, Joseph; Verberne, Hein J.; Taylor, John-Paul; O'Brien, John T.; Thomas, Alan J.; DLB Indicative Imaging Biomarker Study Group (Wiley on behalf of the Alzheimer's Association, 2026-03-04)
    Introduction: The aim of this Delphi process was to develop consensus guidelines to support the effective use of striatal dopaminergic imaging and cardiac metaiodobenzylguanidine (MIBG) scintigraphy in the diagnosis of ...
  • Eye tracking as a diagnostic tool in Alzheimer's disease, mild cognitive impairment, and related dementias: a systematic review 
    Verón, Gustavo Luis; Juantorena, Gustavo Ezequiel; Keller, Greta; Crivelli, Lucía; Kamienkowski, Juan Esteban (Wiley, 2025-12-30)
    Alzheimer's disease (AD) pathology begins years before symptoms emerge, making early detection essential. Eye tracking offers a rapid, non-invasive means of identifying early cognitive decline through oculomotor disturbances. ...
  • Scientific knowledge about dementia: From the Global South to the world 
    Daly, Timothy; López Barrenechea, Ignacio; Vergara, Paulina; Arshad, Faheem; Paplikar, Avanthi; Chaudhuri, Aparajita Ray; Crivelli, Lucía; Ibañez, Agustín; Alladi, Suvarna; Slachevsky, Andrea (Wiley, 2026-03)
    Most people with dementia live in low- and middle-income countries (LMICs), but scientific knowledge about dementia is dominated by Global North perspectives. This interdisciplinary article combines expertise from Latin ...
  • Dementia screening protocol for primary care in South America: a Delphi consensus study 
    Custodio, Belen; Montesinos, Rosa; Caramelli, Paulo; Calandri, Ismael Luis; Dozzi Brucki, Sonia María; Suemoto, Claudia Kimie; Allegri, Ricardo Francisco; Slachevsky, Andrea; Parodi, Jose F.; Morsch, Patricia; Willets, Clarissa; Cuba Fuentes, María Sofía; Custodio, Nilton (Frontiers Editorial Office, 2026-04-08)
    Introduction: Rapid population aging in South America (SA) highlights the need for effective dementia detection strategies. Primary care is essential for early identification, yet no shared, regionally contextualized ...

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