Neurología: Recent submissions

  • Disease activity after discontinuation of disease-modifying therapies in patients with multiple sclerosis in Argentina: data from the nationwide registry RelevarEM 
    Zanga, Gisela; Portinari, Carla; Barber, Josefina; Ibañez, Tomas; Brolese, Lucía; Pappolla, Agustín; Miguez, Jimena; Patrucco, Liliana; Cristiano, Edgardo; Deri, Norma; Tkachuk, Verónica A.; Vrech, Carlos; Cohen, Leila; Alonso, Ricardo; Garcea, Orlando; Ysrraelit, María Célica; Marrodán, Mariano; Gaitán, María Inés; Correale, Jorge; RELEVAREM Study Group (Taylor & Francis, 2022-10-02)
    Introduction: The discontinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS) is commonly seen in real-world settings due to several factors. Area cover: The aim of this study is to describe the ...
  • Systemic Ghrelin Treatment Induces Rapid, Transient, and Asymmetric Changes in the Metabolic Activity of the Mouse Brain 
    de Francesco, Pablo Nicolás; Fernández, Gimena; Uriarte, Maia; Urrutia, Leandro; Ponce de León, Magdalena; Fehrentz, Jean-Alain; Falasco, Germán; Perello, Mario (Karger, 2022-07-29)
    Introduction: Ghrelin regulates a variety of functions by acting in the brain. The targets of ghrelin in the mouse brain have been mainly mapped using immunolabeling against c-Fos, a transcription factor used as a marker ...
  • Abstract WMP9: Favorable Mechanical Thrombectomy Outcomes From The Latin American Stroke Registry (lase) And Resilient Trial Compared To A 90-day Functional And Mortality Predictive Model 
    Torrealba-Acosta, Gabriel; Barboza, Miguel A.; Arauz-Gongora, Antonio; Amaya, Pablo; Ameriso, Sebastián Francisco; Cano, Vanessa; Flores, Alan; Lavados, Pablo M.; Pujol Lereis, Virginia Andrea; Serrano, Fabiola; Kent, Thomas A.; Mandava, Pitchaiah (Lippincott Williams & Wilkins, 2023-02-02)
    Introduction: Except for RESILIENT, there is a paucity of randomized controlled trials (RCTs) for stroke from Latin America (LA), home to growing stroke burden. Comparison between stroke population typically suffers from ...
  • Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus 
    Čarna, Maria; Onyango, Isaac G.; Katina, Stanislav; Holub, Dušan; Novotny, Jan Sebastian; Nezvedova, Marketa; Jha, Durga; Nedelska, Zuzana; Lacovich, Valentina; Vande Vyvere, Thijs; Houbrechts, Ruben; Garcia-Mansfield, Krystine; Sharma, Ritin; David-Dirgo, Victoria; Vyhnalek, Martin; Texlova, Kateřina; Chaves, Hernán; Bakkar, Nadine; Pertierra, Lucía; Sevlever, Gustavo Emilio (Wiley, 2023-02-24)
    The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation ...
  • Abstract WP14: A Patient-level Data Euclidean-matched Analysis Of Reperfusion Therapies In Acute Ischemic Stroke From The Latin American Stroke Registry (lase) 
    Barboza, Miguel A.; Torrealba-Acosta, Gabriel; Valdez, Hector; Arauz-Gongora, Antonio; Abanto Argomedo, Carlos; Amaya, Pablo; Ameriso, Sebastián Francisco; Bonardo, Pablo; Cano, Vanessa; Diaz-Escobar, Luis; Ecos, Rosa Lizbeth; Fernández Morales, Huberth; Gómez Schneider, Maia Macarena; Gongora Rivera, Fernando F.; Huamani, Charles; Lavados, Pablo M.; Marquez Romero, Juan Manuel; Martins, Sheila C.; Navia, Víctor Hugo; Pujol Lereis, Virginia Andrea (Lippincott Williams & Wilkins, 2023-02-02)
    Introduction: As acute stroke therapies expand to less well-resourced regions, it is imperative to study real-world data to assess outcomes and the quality of stroke care. The present study analyzes clinical, and imaging ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort 
    Vollstedt, Eva-Juliane; Schaake, Susen; Lohmann, Katja; Padmanabhan, Shalini; Brice, Alexis; Lesage, Suzanne; Tesson, Christelle; Vidailhet, Marie; Wurster, Isabel; Hentati, Faycel; Mirelman, Anat; Giladi, Nir; Marder, Karen S.; Waters, Cheryl; Fahn, Stanley; Kasten, Meike; Brüggemann, Norbert; Rossi, Malco Damián; Merello, Marcelo; MJFF Global Genetic Parkinson's Disease Study Group (Wiley, 2023-01-24)
    Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of ...
  • LatAm Fingers Initiative: Bringing Diversity Upfront 
    Crivelli, Lucía (The Alzheimer's Association, 2022-12)
  • Life events and the onset of motor symptoms in Parkinson's disease 
    Páez Maggio, Mauricio; Rossi, Malco Damián; Martinez, V.; Wainberg, Florencia N.; Merello, Marcelo (Elsevier, 2023-01-11)
    Background: Whether there may be any relationship between stressful or traumatic life events (LE) and the subsequent motor symptoms onset in Parkinson's disease (PD) is still controversial. Objectives: To explore whether ...
  • Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study 
    Millar, Peter R.; Gordon, Brian A.; Luckett, Patrick H.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Fagan, Anne M.; Hassenstab, Jason; Perrin, Richard J.; Schindler, Suzanne E.; Allegri, Ricardo Francisco; Day, Gregory S.; Farlow, Martin R.; Mori, Hiroshi; Nübling, Georg; Dominantly Inherited Alzheimer Network; Bateman, Randall J.; Morris, John C.; Ances, Beau M. (eLife Sciences Publications, 2023-01-06)
    Background: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic ...
  • LatAm Fingers Initiative: Challenges and opportunities of launching amulticultural trial in pandemic times 
    Calandri, Ismael Luis; Crivelli, Lucía; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Mónica; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; LatAm FINGERS (The Alzheimer's Association, 2022-12-20)
  • LatAm FINGERS:Overcoming Barriers for a Dementia Prevention Trial Startup 
    Calandri, Ismael Luis; Crivelli, Lucía; Caramelli, Paulo; Lopera, Francisco; Nitrini, Ricardo; Sosa, Ana Luisa; Salinas Contreras, Rosa María; Suemoto, Claudia Kimie; Velilla, Lina M.; Sanches Yassuda, Mónica; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco; LatAm FINGERS (The Alzheimer's Association, 2022)
  • Comparison of amyloid accumulation between Down syndrome and autosomal-dominant Alzheimer disease 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Klunk, William E.; Rafii, Michael S.; O’Bryant, Sid E.; Price, Julie C.; Schupf, Nicole; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network (The Alzheimer’s Association, 2022)
  • Shared decision making in the treatment of multiple sclerosis: A consensus based on Delphi methodology 
    Alonso, Ricardo; Carnero Contentti, Edgar; Graña, Marcos; Linares, Ramiro; López, Pablo Adrián; Mainella, Carolina; Marrodán, Mariano; Miguez, Jimena; Pagani Cassará, Fátima; Tavolini, Darío; Batagelj, Sebastián (Elsevier, 2022-12-09)
    Shared decision making is a way of incorporating patients' preferences and values into the decisions regarding the treatment and follow-up plan for the condition that affects them. It is currently applied mainly in the ...
  • Teleneuropsychological assessment in South America: A perspective from patients and neuropsychologists 
    Arruabarrena, Micaela María; Martin, María Eugenia; Calandri, Ismael Luis; Corvalán, Nicolás; Helou, María Belén; Martínez Canyazo, Carlos; Crivelli, Lucía (Universidad de la Costa, 2022-12-23)
    Teleneuropsychology (teleNP) in Argentina was promoted by the COVID-19 pandemic. This investigation aimed to evaluate patients’ and neuropsychologists’ satisfaction with teleNP and to identify the advantages and disadvantages ...
  • La Organización Mundial de la Salud acaba de lanzar un Blueprint for Dementia Research. Algunas notas para impulsar la investigación sobre la demencia en América Latina... 
    Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2022-12-28)
    La demencia es la causa más importante de discapacidad y dependencia en los adultos mayores y actualmente afecta a más de 55 millones de personas, el 60% de las cuales vive en países de ingresos bajos y medios (PRMB). El ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Incidence of COVID-19 after vaccination in people with multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM 
    Rojas, Juan Ignacio; Luetic, Geraldine G.; Vrech, Carlos; Pappolla, Agustín; Patrucco, Liliana; Cristiano, Edgardo; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Correale, Jorge; Cohen, Leila; Alonso, Ricardo; Silva, Berenice Anabel; Casas, Magdalena; Garcea, Orlando; Deri, Norma; Burgos, Marcos; Liwacki, Susana; Tkachuk, Verónica A.; Barboza, Andrés G. (Elsevier B. V., 2022-12)
    The objective of the study was to evaluate the incidence of COVID-19 after complete vaccination in people with multiple sclerosis (PwMS) included in the Argentinean MS and NMOSD registry (RelevarEM, NCT03375177). Methods: ...
  • Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole S.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)
    Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
  • Control of Vascular Risk Factors and Response to Stroke Symptoms in Argentina During the COVID-19 Quarantine. The SIFHON-COVID Population Survey 
    Rodríguez Pérez, María S.; Rosales, Julieta Soledad; Dossi, Daiana Elizabeth; Ameriso, Sebastián Francisco (Frontiers Research Foundation, 2022-04-11)
    Background and objectives: In preparation for the suspected influx of COVID-19 patients, many healthcare systems reduced or discontinued provision of "non-urgent" care. This decision had potential impact on stroke prevention ...

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