Neurología: Recent submissions

  • Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention 
    Sharma, Mukul; Dong, Qiang; Hirano, Teruyuki; Kasner, Scott E.; Saver, Jeffrey; Masjuan, Jaime; Demchuk, Andrew M.; Cordonnier, Charlotte; Bereczki, Daniel; Tsivgoulis, Georgios; Veltkamp, Roland; Staikov, Ivan; Bae, Hee-Joon; Campbell, Bruce C. V.; Zini, Andrea; Lee, I-Hui; Ameriso, Sebastián Francisco; Kovar, Martin; Mikulik, Robert; Lemmens, Robin (Oxford, 2026-01-01)
    Introduction: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to ...
  • Characterizing double seronegative neuromyelitis optica spectrum disorder: A distinct subgroup or part of the continuum? 
    Piedrabuena, María Agustina; Marrodán, Mariano; Zárate, María Agustina; Fiol, Marcela; Ysrraelit, María Célica; Correale, Jorge (Elsevier, 2025-12-01)
    Background: Neuromyelitis optica spectrum disorder (NMOSD) encompasses inflammatory demyelinating CNS conditions. Patients negative for aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies ...
  • The Neurochemical Landscape of Oligodendrocyte Physiology: From Myelination to Metabolic and Synaptic Modulation 
    Correale, Jorge (Wiley, 2025-12-11)
    Oligodendrocytes, traditionally recognized for their role in axonal myelination, are increasingly appreciated as metabolically dynamic and functionally diverse cells integral to central nervous system (CNS) homeostasis. ...
  • Diagnostic value of genetic testing, with focus on CACNA1A, in children with episodic neurologic disorders: a single-centre retrospective study 
    Chinigioli, Micaela; Martí-Sanchez, Laura; Yubero, Delia; Xiol, Clara; Olival, Jonathan; Alcalá San Martín, Adrián; Hernando-Davalillo, Cristina; Martorell, Loreto; Armstrong, Judith; Schteinschnaider, Ángeles; Ortigoza-Escobar, Juan Darío (Elsevier, 2025-12-03)
    Background: Episodic neurologic disorders, such as paroxysmal torticollis, paroxysmal tonic upward gaze deviation, migraine, and episodic ataxia, represent a diagnostic challenge in paediatric patients. Variants in the ...
  • Functional validation of the PSEN1 R358P and PSEN1 T119I variants in Alzheimer's Disease: an in vitro study 
    García Chialva, Diego; Cifarelli, Diego; Isaja, Luciana; Apecetche, Manuela; Martínes Ojeda, Laura; Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Sevlever, Gustavo Emilio; Scassa, Maria; Surace, Ezequiel Ignacio; Romorini, Leonardo (Wiley, 2025-12-23)
    Background Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. It is characterized by progressive neuronal degeneration and the accumulation of beta‐amyloid plaques (Aβ) ...
  • Cortical asymmetry in autosomal dominant Alzheimer's disease progression 
    Pérez-Millan, Agnès; Falgàs, Neus; Bosch, Beatriz; Borrego-Écija, Sergi; Antonell, Anna; Fernández-Villullas, Guadalupe; Esteller-Gauxax, Diana; Tort-Merino, Adrià; Bargalló, Núria; Balasa, Mircea; Lladó, Albert; Aguillon, David; Chrem Méndez, Patricio Alexis; Day, Gregory S.; Devenney, Emma; Huey, Edward D.; Ikeuchi, Takeshi; Jucker, Mathias; Kasuga, Kensaku; Dominantly Inherited Alzheimer Network (DIAN) (Oxford University Press, 2025-12-19)
    The cortical asymmetry index evaluates the cortical thickness asymmetry between hemispheres. We investigated cortical asymmetry index in asymptomatic and symptomatic mutation carriers of autosomal dominant Alzheimer's ...
  • Executive Functions in Latin American Older Adults: Exploring the Concept Shifting Test and Its Relationship with the APOE Gene in a Cross‐Sectional Sample from the LatAm‐FINGERS Study 
    Melillo Cardoso, Davi; Vasconcelos Friedlander, Clarisse; Sanches Yassuda, Monica; Cruz de Souza, Leonardo; Crivelli, Lucía; Kimie Suemoto, Claudia; Martin, Maria Eugenia; Calandri, Ismael Luis; Acosta‐Baena, Natalia; Surace, Ezequiel Ignacio; Damian, Andrés; Da Graça Morais Martin, Maria; Vigil‐Martinez, Ana; Henrique Cançado, Gustavo; Salinas‐Contreras, Rosa Maria; Custodio, Belen; Cusicanqui, María Isabel; Delgado, Carolina; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Wiley, 2025-12-26)
    Background Latin America (LA) faces high vulnerability to dementia risk factors. Early detection of cognitive decline, particularly in executive functions (EF), is crucial. The Trail Making Test (TMT) has limitations, ...
  • Cognitive and neuroimaging trajectories in the behavioral variant of Alzheimer's disease 
    Calandri, Ismael Luis; Phillips, Jeffrey S.; Tideman, Pontus; Singleton, Ellen Hanna; La Joie, Renaud; van der Flier, Wiesje M.; Jonkman, Laura E.; Hansson, Oskar; Rabinovici, Gil D.; Pijnenburg, Yolande A. L.; Ossenkoppele, Rik; Mastenbroek, Sophie E. (Wiley, 2025-12-26)
    Background The behavioral variant of Alzheimer's disease (bvAD) is a rare atypical presentationcharacterized by early and prominent behavioral changes, clinically akin to the behavioral variant of fronto‐temporal dementia ...
  • Chorea and Levodopa-Induced Dyskinesia in Corticobasal Syndrome: Two Case Reports with Pathological Insights and Literature Review 
    Medina Escobar, Alex; Rossi, Malco Damián; Richer, Maxime; Gautreau, Sylvia; Lang, Anthony E. (Wiley, 2025-05-11)
    Background: Corticobasal syndrome (CBS) is a rare, clinically heterogeneous form of atypical Parkinsonism. Hyperkinetic movements, aside from myoclonus and dystonia, have rarely been reported in CBS. Cases: We present ...
  • CADASIL Argentine Registry: Study Design and Preliminary Data 
    Ardohain Cristalli, Carolina Agata; Rosales, Julieta Soledad; Gonzalez, Fabio; Selvaggi, Valentin; Alonso, Julián Martín; López, Juan Ignacio; Aguilar, Martín Santiago; Kauffman, Marcelo; Saks, Danit G.; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Chaves, Hernán; Cristalli, Diana Olga; Calandri, Ismael Luis (Wiley, 2024)
    Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common hereditary small vessel disease, leads to early-onset stroke and vascular cognitive ...
  • The Role of Basal Ganglia Theta Oscillations in Predicting the Onset of Levodopa-Induced Dyskinesias 
    Wilken, Miguel; Granda, Luna; Cruz, Ivonne; Rossi, Malco Damián; Cerquetti, Daniel; Merello, Marcelo (Wiley, 2025-10-11)
    Background: Levodopa-induced dyskinesias (LIDs) are an important burden for patients with Parkinson's disease (PD), yet their mechanisms remain incompletely understood. Objective: The objective of this study was to ...
  • Childhood and Adolescent Environmental Risk Factors for Multiple Sclerosis: A Systematic Review With Meta-Analysis 
    Vitturi, Bruno Kusznir; Cellerino, Maria; Boccia, Daniele; Leray, Emmanuelle; Correale, Jorge; Dobson, Ruth; van der Mei, Ingrid; Fujihara, Kazuo; Inglese, Matilde (Wiley, 2025-10-28)
    Background: We aimed to provide updated evidence from the current literature regarding pediatric environmental factors associated with the risk of developing multiple sclerosis (MS). Methods: Articles were searched in ...
  • SmartRehab: Enhancing Stroke Recovery through Automated Telerehabilitation (P7-14.011) 
    Velez, Faddi Saleh; Yeung, Elton; Bonin Pinto, Camila; Ling, Tsei Mei; Alet, Matías Javier; Carbonera, Leonardo; Ciopleias, Bogdan; khan, Abdul; Law, Zhe Kang; Lotlikar, Radhika; Liu, Roxanna; So, Adrian; Chan, Yin; Poon, Gloria; Boada Robayo, Laura; Rudyk, Demian; Kiper, Pawel; Yabluchanskiy, Andriy; Savitz, Sean; Luo, Louis (Lippincott Williams & Wilkins, 2025-04-07)
    Objective: We tested the SmartRehab efficacy, usability, and feasibility for stroke rehabilitation across seven countries. Background: Stroke is a major cause of disability worldwide. Timely and personalized rehabilitation ...
  • Clinical Validation of the SECONDs Tool for Evaluating Disorders of Consciousness in Argentina 
    Russo, María Julieta; Sampayo, María de la Paz; Arias, Paula; García, Vanina; Gambero, Yanina; Maiarú, Mariano; Deschle, Florencia; Pavón, Hernán (MDPI, 2025-10-07)
    Background: The Coma Recovery Scale-Revised (CRS-R) is the gold standard for diagnosing chronic disorders of consciousness (DoC); however, its clinical utility is limited by lengthy administration and the need for specialized ...
  • Associations of lifestyle factors with amyloid pathology in persons without dementia 
    Oomens, Julie E.; Vos, Stephanie Jb; Maserejian, Nancy N.; Boada, Mercè; Didic, Mira; Engelborghs, Sebastiaan; Fladby, Tormod; van der Flier, Wiesje M.; Frisoni, Giovanni B.; Fröhlich, Lutz; Gill, Kiran Dip; Grimmer, Timo; Hort, Jakub; Allegri, Ricardo Francisco; Alzheimer's Disease Neuroimaging Initiative (ADNI); A4 Study group; Dominantly Inherited Alzheimer Network (DIAN); European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI); Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE); Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group (Sage, 2025-11-13)
    BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking ...
  • Latin America Multidisciplinary Consensus Panel on Management of Severe Bleeding in the Anticoagulated Patient 
    Pontes-Neto, Octávio M.; Noble-Lugo, Alejandra; Montenegro Arenas, Ana Cristina; de Campos Guerra, Joao Carlos; Ceresetto, Jose Manuel; Rosales, Julieta Soledad; Colunga-Lozano, Luis Enrique; Meillon-Garcia, Luis Antonio; Vargas Tellez, Luis Eduardo; Dos Reis Rodrigues, Roseny; Gibler, W. Brian; Kreitzer, Natalie P. (Elsevier, 2025-05-05)
    Background: Bleeding is the most important complication associated with anticoagulants. Patients experiencing bleeding while on an anticoagulation require proper risk stratification, which involves careful assessment of ...
  • Efficacy and safety of Cladribine as a therapeutic option in multiple sclerosis patients over 50 years of age: A real-world study 
    Piedrabuena, María Agustina; Correale, Jorge; Silva, Berenice; Fiol, Marcela; Marrodán, Mariano; Zárate, María Agustina; Heriz, Alejandra; Ayerbe, Jeremías; Míguez, Jimena; Pita, Cecilia; Lázaro, Luciana; Casas, Magdalena; López, Pablo Adrián; Tkachuk, Verónica; Balbuena, María Eugenia; Nadur, Débora; Liwacki, Susana; Luetic, Geraldine; Burgos, Marcos; Ysrraelit, María Célica (Elsevier, 2025-11-15)
    Background: Despite an aging multiple sclerosis (MS) population, clinical outcomes and long-termeffects of disease-modifying therapies in patients aged ≥50 years remain under-studied. Objective: To compare the efficacy ...
  • Quantitative Assessment of Proprioceptive Force Perception in Parkinson’s Disease Using a Sensor-Based Grip Task 
    Martínez de Sucre, M. Nahuel; Bianchi, Gianfranco; Wilken, Miguel; Cruz Molina, Cecilia; Noel, Gabriel; Andrés, Daniela (Springer, 2025-10-16)
    Parkinson’s disease (PD) is characterized by progressive motor and sensorimotor deficits, including impairments in proprioception and grip force control. Despite their clinical relevance, these alterations are rarely ...
  • Therapeutic Plasma Exchange in Corticosteroid-Refractory Multiple Sclerosis Relapses: Mechanisms, Efficacy, and Integration into Clinical Practice 
    Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge (MDPI, 2025-09-30)
    Therapeutic plasma exchange (TPE) is increasingly recognized as a critical escalation therapy for managing acute multiple sclerosis (MS) relapses refractory to high-dose corticosteroids. Neuropathological and clinical ...
  • Anti-NMDAR encephalitis across the lifespan: Clinical, electrophysiological, and prognostic insights from a Latin American cohort 
    Marrodán, Mariano; Perez Arana, Carolina I.; Kirchner, Ricardo J.; Varela, Francisco José; Orzuza, Gabriela I.; Schteinschnaider, Ángeles; Chaderevian, Miriam G.; Vita, Cristina; Farez, Mauricio Franco; Correale, Jorge (Elsevier, 2025-12-15)
    Background and objectives: Anti-N-Methyl-d-aspartate receptor encephalitis (NMDARE) is the most prevalent autoimmune encephalitis, primarily affecting young females. Its clinical heterogeneity, particularly in underrepresented ...

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