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Pituitary stem cells: past, present and future perspectives

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dc.contributor.author Pérez Millán, María Inés
dc.contributor.author Cheung, Leonard Y.M.
dc.contributor.author Mercogliano, Florencia
dc.contributor.author Camilletti, Maria Andrea
dc.contributor.author Chirino Felker, Gonzalo T.
dc.contributor.author Moro, Lucía Natalia
dc.contributor.author Miriuka, Santiago Gabriel
dc.contributor.author Brinkmeier, Michelle L.
dc.contributor.author Camper, Sally A.
dc.date.accessioned 2024-02-20T15:13:45Z
dc.date.available 2024-02-20T15:13:45Z
dc.date.issued 2023-12-15
dc.identifier.citation Pérez Millán MI, Cheung LYM, Mercogliano F, Camilletti MA, Chirino Felker GT, Moro LN, Miriuka S, Brinkmeier ML, Camper SA. Pituitary stem cells: past, present and future perspectives. Nat Rev Endocrinol. 2024 Feb;20(2):77-92. doi: 10.1038/s41574-023-00922-4. Epub 2023 Dec 15. es_ES
dc.identifier.uri https://doi.org/10.1038/s41574-023-00922-4
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1003
dc.description.abstract Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary hormone-producing cell types as organoids. Wounding and physiological challenges can activate pituitary stem cells, but cell numbers are not fully restored, and the ability to mobilize stem cells decreases with increasing age. The basis of these limitations is still unknown. The regulation of stem cell quiescence and activation involves many different signalling pathways, including those mediated by WNT, Hippo and several cytokines; more research is needed to understand the interactions between these pathways. Pituitary organoids can be formed from human or mouse embryonic stem cells, or from human induced pluripotent stem cells. Human pituitary organoid transplantation is sufficient to induce corticosterone release in hypophysectomized mice, raising the possibility of therapeutic applications. Today, pituitary organoids have the potential to assess the role of individual genes and genetic variants on hormone production ex vivo, providing an important tool for the advancement of exciting frontiers in pituitary stem cell biology and pituitary organogenesis. In this article, we provide an overview of notable discoveries in pituitary stem cell function and highlight important areas for future research. es_ES
dc.language.iso eng es_ES
dc.publisher Nature Pub. Group es_ES
dc.subject Endocrine System Diseases es_ES
dc.subject Enfermedades del Sistema Endocrino es_ES
dc.subject Stem Cells es_ES
dc.subject Células Madre es_ES
dc.title Pituitary stem cells: past, present and future perspectives es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Miriuka, Santiago Gabriel. Fleni. Instituto de Neurociencias FLENI-CONICET. Laboratorio de Investigación Aplicada a las Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Moro, Lucía Natalia. Fleni. Instituto de Neurociencias FLENI-CONICET. Laboratorio de Investigación Aplicada a las Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.relation.ispartofVOLUME 20
dc.relation.ispartofNUMBER 2
dc.relation.ispartofPAGINATION 77-92.
dc.relation.ispartofCOUNTRY Inglaterra
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Nature reviews. Endocrinology
dc.relation.ispartofISSN 1759-5037
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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