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Oxidative stress associated with spatial memory impairment and social olfactory deterioration in female mice reveals premature aging aroused by perinatal protein malnutrition

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dc.contributor.author Ferroni, Nadina M.
dc.contributor.author Chertoff, Mariela J.
dc.contributor.author Alberca, Carolina D.
dc.contributor.author Berardino, Bruno G.
dc.contributor.author Gianatiempo, Octavio
dc.contributor.author Brahamian, Martin
dc.contributor.author Levi, Valeria
dc.contributor.author Urrutia, Leandro
dc.contributor.author Falasco, Germán
dc.contributor.author Cánepa, Eduardo Tomás
dc.contributor.author Sonzogni, Silvina V.
dc.date.accessioned 2024-02-21T17:09:07Z
dc.date.available 2024-02-21T17:09:07Z
dc.date.issued 2023-07-16
dc.identifier.citation Ferroni NM, Chertoff MJ, Alberca CD, Berardino BG, Gianatiempo O, Brahamian M, et al. Oxidative stress associated with spatial memory impairment and social olfactory deterioration in female mice reveals premature aging aroused by perinatal protein malnutrition. Exp Neurol. octubre de 2023;368:114481. es_ES
dc.identifier.uri https://doi.org/10.1016/j.expneurol.2023.114481
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1006
dc.description.abstract Early-life adversity, like perinatal protein malnutrition, increases the vulnerability to develop long-term alterations in brain structures and function. This study aimed to determine whether perinatal protein malnutrition predisposes to premature aging in a murine model and to assess the cellular and molecular mechanisms involved. To this end, mouse dams were fed either with a normal (NP, casein 20%) or a low-protein diet (LP, casein 8%) during gestation and lactation. Female offspring were evaluated at 2, 7 and 12 months of age. Positron emission tomography analysis showed alterations in the hippocampal CA3 region and the accessory olfactory bulb of LP mice during aging. Protein malnutrition impaired spatial memory, coinciding with higher levels of reactive oxygen species in the hippocampus and sirt7 upregulation. Protein malnutrition also led to higher senescence-associated β-galactosidase activity and p21 expression. LP-12-month-old mice showed a higher number of newborn neurons that did not complete the maturation process. The social-odor discrimination in LP mice was impaired along life. In the olfactory bulb of LP mice, the senescence marker p21 was upregulated, coinciding with a downregulation of Sirt2 and Sirt7. Also, LP-12-month-old mice showed a downregulation of catalase and glutathione peroxidase, and LP-2-month-old mice showed a higher number of newborn neurons in the subventricular zone, which then returned to normal values. Our results show that perinatal protein malnutrition causes long-term impairment in cognitive and olfactory skills through an accelerated senescence phenotype accompanied by an increase in oxidative stress and altered sirtuin expression in the hippocampus and olfactory bulb. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.subject Aging, Premature es_ES
dc.subject Envejecimiento Prematuro es_ES
dc.subject Caseins es_ES
dc.subject Caseínas es_ES
dc.subject Malnutrition es_ES
dc.subject Malnutrición es_ES
dc.subject Memory Disorders es_ES
dc.subject Trastornos de la Memoria es_ES
dc.subject Olfactory Bulb es_ES
dc.subject Bulbo Olfatorio es_ES
dc.subject Oxidative Stress es_ES
dc.subject Estrés Oxidativo es_ES
dc.subject Pregnancy es_ES
dc.subject Embarazo es_ES
dc.subject Spatial Memory es_ES
dc.subject Memoria Espacial es_ES
dc.title Oxidative stress associated with spatial memory impairment and social olfactory deterioration in female mice reveals premature aging aroused by perinatal protein malnutrition es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Urrutia, Leandro. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.description.fil Fil: Falasco, Germán. Fleni. Departamento de Diagnóstico por Imágenes. Centro de Imágenes Moleculares; Argentina.
dc.relation.ispartofVOLUME 368
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Orlando
dc.relation.ispartofTITLE Experimental neurology
dc.relation.ispartofISSN 1090-2430
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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