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Guillain-Barré Syndrome and COVID-19 Vaccine: A Multicenter Retrospective Study of 46 Cases

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dc.contributor.author Castiglione, Juan Ignacio
dc.contributor.author Crespo, José Manuel
dc.contributor.author Bendersky, Mariana
dc.contributor.author Silveira, Facundo Oscar
dc.contributor.author Lecchini, Lucila
dc.contributor.author Luis, María Belén
dc.contributor.author Caiza Zambrano, Francisco
dc.contributor.author Cotti, Norberto
dc.contributor.author Simison, Conrado J.
dc.contributor.author Aguirre, Florencia
dc.contributor.author Piedrabuena, María Agustina
dc.contributor.author Alonso, Ricardo
dc.contributor.author Azcona, Carolina Laura
dc.contributor.author Sosa, Pablo Sebastian
dc.contributor.author Maldonado, Evangelina
dc.contributor.author Varela, Francisco José
dc.contributor.author Bettini, Mariela
dc.contributor.author Rey, Roberto D.
dc.contributor.author León Cejas, Luciana
dc.contributor.author Barroso, Fabio Adrián
dc.date.accessioned 2024-02-27T17:26:46Z
dc.date.available 2024-02-27T17:26:46Z
dc.date.issued 2023-09-01
dc.identifier.citation Castiglione JI, Crespo JM, Bendersky M, Silveira FO, Lecchini L, Luis MB, et al. Guillain-Barré Syndrome and COVID-19 Vaccine: A Multicenter Retrospective Study of 46 Cases. J Clin Neuromuscul Dis. 1 de septiembre de 2023;25(1):1-10. es_ES
dc.identifier.uri https://doi.org/10.1097/CND.0000000000000437
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1025
dc.description.abstract In the context of the global vaccination campaign against COVID-19, several cases of postvaccinal Guillain-Barré syndrome (GBS) were reported. Whether a causal relationship exists between these events has yet to be established. We investigated the clinical and electromyographic characteristics of patients who developed GBS after COVID-19 vaccination and compare these with findings in patients with GBS, without a history of recent vaccination. We included 91 cases between March 2020 and March 2022, treated at 10 referral hospitals of Buenos Aires, Argentina. Of these, 46 had received vaccination against COVID-19 within the previous month. Although Medical Research Council sum-scores were similar in both groups (median 52 vs. 50; P = 0.4), cranial nerve involvement was significantly more frequent in the postvaccination group (59% vs. 38%; P = 0.02), as was bilateral facial paralysis (57% vs. 24%; P = 0.002). No differences were found in clinical or neurophysiological phenotypes, although 17 subjects presented the variant of bilateral facial palsy with paresthesias (11 vs. 6; P = 0.1); nor were significant differences observed in length of hospital stay or mortality rates. Future vaccine safety monitoring and epidemiology studies are essential to demonstrate any potential causal relationship between these events. es_ES
dc.language.iso eng es_ES
dc.publisher Lippincott Williams & Wilkins es_ES
dc.subject COVID-19 Vaccines es_ES
dc.subject Vacunas contra la COVID-19 es_ES
dc.subject Guillain-Barre Syndrome es_ES
dc.subject Síndrome de Guillain-Barré es_ES
dc.subject Paresthesia es_ES
dc.subject Parestesia es_ES
dc.title Guillain-Barré Syndrome and COVID-19 Vaccine: A Multicenter Retrospective Study of 46 Cases es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Castiglione, Juan Ignacio. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Crespo, Marcos José. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Varela, Francisco José. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Barroso, Fabio Adrián. Fleni. Departamento de Neurología. Sección de Enfermedades Neuromusculares; Argentina.
dc.relation.ispartofVOLUME 25
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 1-10
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Journal of clinical neuromuscular disease
dc.relation.ispartofISSN 1537-1611
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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