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The clinical and biochemical spectrum of ectopic acromegaly

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dc.contributor.author Fainstein Day, Patricia
dc.contributor.author Ullmann, Tamara Estefanía
dc.contributor.author Dalurzo, Mercedes Corina Liliana
dc.contributor.author Sevlever, Gustavo Emilio
dc.contributor.author Smith, David Eduardo
dc.date.accessioned 2024-03-05T11:30:20Z
dc.date.available 2024-03-05T11:30:20Z
dc.date.issued 2024-02-14
dc.identifier.citation Fainstein-Day P, Ullmann TE, Dalurzo MCL, Sevlever GE, Smith DE. The clinical and biochemical spectrum of ectopic acromegaly. Best Pract Res Clin Endocrinol Metab. 2024 Feb 14:101877. doi: 10.1016/j.beem.2024.101877. Epub ahead of print. es_ES
dc.identifier.uri https://doi.org/10.1016/j.beem.2024.101877
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1029
dc.description.abstract Ectopic acromegaly is a rare condition caused by extrapituitary central or peripheral neuroendocrine tumours (NET) that hypersecrete GH or, more commonly, GHRH. It affects less than 1% of acromegaly patients and a misdiagnosis of classic acromegaly can lead to an inappropriate pituitary surgery. Four types of ectopic acromegaly have been described: 1) Central ectopic GH-secretion: Careful cross-sectional imaging is required to exclude ectopic pituitary adenomas. 2) Peripheral GH secretion: Extremely rare. 3) Central ectopic GHRH secretion: Sellar gangliocytomas immunohistochemically positive for GHRH are found after pituitary surgery. 4) Peripheral GHRH secretion: The most common type of ectopic acromegaly is due to peripheral GHRH-secreting NETs. Tumours are large and usually located in the lungs or pancreas. Pituitary hyperplasia resulting from chronic GHRH stimulation is difficult to detect or can be misinterpreted as pituitary adenoma in the MRI. Measurement of serum GHRH levels is a specific and useful diagnostic tool. Surgery of GHRH-secreting NETs is often curative. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.subject Acromegaly es_ES
dc.subject Acromegalia es_ES
dc.subject Endocrine System Diseases es_ES
dc.subject Enfermedades del Sistema Endocrino es_ES
dc.subject Paraneoplastic Endocrine Syndromes es_ES
dc.subject Síndromes Paraneoplásicos Endocrinos es_ES
dc.title The clinical and biochemical spectrum of ectopic acromegaly es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular. Laboratorio de Enfermedades Neurodegenerativas; Argentina.
dc.relation.ispartofPAGINATION 101877
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Ámsterdam
dc.relation.ispartofTITLE Best practice & research. Clinical endocrinology & metabolism
dc.relation.ispartofISSN 1878-1594
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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