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Predictors and Pathophysiology of Axial Postural Abnormalities in Parkinsonism: A Scoping Review

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dc.contributor.author Artusi, Carlo Alberto
dc.contributor.author Geroin, Christian
dc.contributor.author Nonnekes, Jorik
dc.contributor.author Aquino, Camila
dc.contributor.author Garg, Divyani
dc.contributor.author Dale, Marian L.
dc.contributor.author Schlosser, Darbe
dc.contributor.author Lai, Yijie
dc.contributor.author Al-Wardat, Mohammad
dc.contributor.author Salari, Mehri
dc.contributor.author Wolke, Robin
dc.contributor.author Tsinda Labou, Valery
dc.contributor.author Imbalzano, Gabriele
dc.contributor.author Camozzi, Serena
dc.contributor.author Merello, Marcelo
dc.contributor.author Bloem, Bastiaan R.
dc.contributor.author Capato, Tamine
dc.contributor.author Djaldetti, Ruth
dc.contributor.author Doherty, Karen
dc.contributor.author International Parkinson and Movement Disorders Society Task Force on Postural Abnormalities
dc.date.accessioned 2024-03-07T13:51:31Z
dc.date.available 2024-03-07T13:51:31Z
dc.date.issued 2023-09-06
dc.identifier.citation Artusi CA, Geroin C, Nonnekes J, Aquino C, Garg D, Dale ML, et al. Predictors and Pathophysiology of Axial Postural Abnormalities in Parkinsonism: A Scoping Review. Mov Disord Clin Pract. noviembre de 2023;10(11):1585-96 es_ES
dc.identifier.uri https://doi.org/10.1002/mdc3.13879
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1036
dc.description.abstract Background: Postural abnormalities involving the trunk are referred to as axial postural abnormalities and can be observed in over 20% of patients with Parkinson's disease (PD) and in atypical parkinsonism. These symptoms are highly disabling and frequently associated with back pain and a worse quality of life in PD. Despite their frequency, little is known about the pathophysiology of these symptoms and scant data are reported about their clinical predictors, making it difficult to prompt prevention strategies. Objectives: We conducted a scoping literature review of clinical predictors and pathophysiology of axial postural abnormalities in patients with parkinsonism to identify key concepts, theories and evidence on this topic. Methods: We applied a systematic approach to identify studies, appraise quality of evidence, summarize main findings, and highlight knowledge gaps. Results: Ninety-two articles were reviewed: 25% reported on clinical predictors and 75% on pathophysiology. Most studies identified advanced disease stage and greater motor symptoms severity as independent clinical predictors in both PD and multiple system atrophy. Discrepant pathophysiology data suggested different potential central and peripheral pathogenic mechanisms. Conclusions: The recognition of clinical predictors and pathophysiology of axial postural abnormalities in parkinsonism is far from being elucidated due to literature bias, encompassing different inclusion criteria and measurement tools and heterogeneity of patient samples. Most studies identified advanced disease stage and higher burden of motor symptoms as possible clinical predictors. Pathophysiology data point toward many different (possibly non-mutually exclusive) mechanisms, including dystonia, rigidity, proprioceptive and vestibular impairment, and higher cognitive deficits. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Camptocormia es_ES
dc.subject Parkinsonian Disorders es_ES
dc.subject Trastornos Parkinsonianos es_ES
dc.title Predictors and Pathophysiology of Axial Postural Abnormalities in Parkinsonism: A Scoping Review es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Merello, Marcelo. Fleni. Departamento de Neurología. Servicio de Movimientos Anormales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.relation.ispartofVOLUME 10
dc.relation.ispartofNUMBER 11
dc.relation.ispartofPAGINATION 1585-1596
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hoboken
dc.relation.ispartofTITLE Movement disorders clinical practice
dc.relation.ispartofISSN 2330-1619
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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