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Pituitary metastases: a diagnostic and therapeutic challenge

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dc.contributor.author Loto, Mónica
dc.contributor.author Rogozinski, Amelia
dc.contributor.author Alfieri, Analía
dc.contributor.author Ballarino, María C.
dc.contributor.author Battistone, María Florencia
dc.contributor.author Chervin, Alberto
dc.contributor.author Danilowicz, Karina
dc.contributor.author Diez, Sabrina
dc.contributor.author Fainstein Day, Patricia
dc.contributor.author Furioso, Alejandra
dc.contributor.author Glerean, Mariela
dc.contributor.author González Pernas, Mariana
dc.contributor.author Katz, Débora Adela
dc.contributor.author Mallea Gil, María S.
dc.contributor.author Martínez, Marcela
dc.contributor.author Miragaya, Karina A.
dc.contributor.author Sabate, Maria I.
dc.contributor.author Slavinsky, Patricia
dc.contributor.author Sosa, Soledad
dc.contributor.author Szuman, Gabriela
dc.contributor.author Tkatch, Julieta
dc.contributor.author Vitale, Marcelo N.
dc.contributor.author Guitelman, Mirtha
dc.date.accessioned 2024-08-05T12:23:43Z
dc.date.available 2024-08-05T12:23:43Z
dc.date.issued 2024
dc.identifier.citation Loto MG, Rogozinski A, Alfieri A, Ballarino MC, Battistone MF, Chervin A, Danilowicz KD, Diez S, Fainstein Day P, Furioso A, Glerean M, Gonzalez Pernas M, Katz D, Mallea Gil MS, Martinez M, Miragaya KA, Sabate MI, Slavinsky P, Sosa S, Szuman G, Tkatch J, Vitale MN, Guitelman M. Metástasis hipofisarias: un desafío diagnóstico y terapéutico [Pituitary metastases: a diagnostic and therapeutic challenge]. Medicina (B Aires). 2024;84(3):505-515. Spanish. es_ES
dc.identifier.uri https://www.medicinabuenosaires.com/PMID/38907965.pdf
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1183
dc.description.abstract Introduction: Sellar metastases (SM) are rare manifestations of malignancy. Breast and lung cancer are the most common primary tumors. Most cases are diagnosed in patients with advanced malignant disease; however, symptoms of pituitary involvement can precede the diagnosis of the primary tumor. Methods: Retrospective analysis of symptoms at presentation, hormonal, radiological and histological findings, management, and outcome of patients with SM from 2009 to 2020. Results: Eighteen patients'cases were included, 11 with histological confirmation. Median (m) age was 53 years (range 35-75), 53% male. Primary malignant tumors: 8 lungs, 6 breast, 1 follicular thyroid carcinoma, 1 Hodgkin lymphoma, and 2 clear cell renal carcinomas. The m time between the diagnosis of the primary neoplasm and the occurrence of the SM was 108 months (range: 11-180). In 8 patients the diagnosis of the primary neoplasm was made after the finding of the symptomatic sellar mass. Insipidus diabetes, adenohypophysis deficit, visual disorders, headache, and cranial nerve deficits were evident in 78, 77, 61, 39 and 39% of the cases, respectively. Fifteen patients harbored supra / parasellar masses, in three a lesion was limited to the pituitary gland, and stalk. Eleven out of 18 (61.1%) of the patients were operated on by the trans-sphenoidal approach, for diagnostic and / or decompressive purposes. Eighteen died, with a median survival time of 6 months (1-36). Discussion: In the presence of a pituitary lesion with diffuse gadolinium uptake, associated with insipidus diabetes and / or visual disorder SM should be suspected even in patients without a history of oncological disease. es_ES
dc.language.iso spa es_ES
dc.publisher Fundación Revista Medicina (Buenos Aires) es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Neoplasias Hipofisarias es_ES
dc.subject Pituitary Neoplasms es_ES
dc.title Pituitary metastases: a diagnostic and therapeutic challenge es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: González Pernas, Mariana Soledad. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Katz, Débora Adela. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.description.fil Fil: Slavinsky, Patricia. Fleni. Departamento de Neurología. Servicio de Neuroendocrinología; Argentina.
dc.relation.ispartofVOLUME 84
dc.relation.ispartofNUMBER 3
dc.relation.ispartofPAGINATION 505-515.
dc.relation.ispartofCOUNTRY Argentina
dc.relation.ispartofCITY Buenos Aires
dc.relation.ispartofCITY Buenos Aires
dc.relation.ispartofTITLE Medicina (B Aires)
dc.relation.ispartofISSN 1669-9106
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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