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Epidemiology of Huntington's Disease in Latin America: A Systematic Review and Meta-Analysis

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dc.contributor.author Medina Escobar, Alex
dc.contributor.author Pringsheim, Tamara
dc.contributor.author Gautreau, Sylvia
dc.contributor.author Rivera Duarte, Jose D.
dc.contributor.author Amorelli, Gabriel
dc.contributor.author Cornejo Olivas, Mario
dc.contributor.author Rossi, Malco
dc.date.accessioned 2024-08-27T14:04:41Z
dc.date.available 2024-08-27T14:04:41Z
dc.date.issued 2024-07-23
dc.identifier.citation Medina Escobar A, Pringsheim T, Gautreau S, Rivera-Duarte JD, Amorelli G, Cornejo-Olivas M, Rossi M. Epidemiology of Huntington's Disease in Latin America: A Systematic Review and Meta-Analysis. Mov Disord. 2024 Jul 23. doi: 10.1002/mds.29929. Epub ahead of print. es_ES
dc.identifier.uri https://doi.org/10.1002/mds.29929
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1200
dc.description.abstract Background: Latin America has played a crucial role in advancing our understanding of Huntington's disease (HD). However, previous global reviews include limited data from Latin America. It is possible that English-based medical search engines may not capture all the relevant studies. Methods: We searched databases in Spanish, Portuguese, and English. The names of every country in Latin America in English-based search engines were used to ensure we found any study that had molecular ascertainment and provided general epidemiological information or subpopulation data. Additionally, we contacted experts across the region. Results: The search strategy yielded 791 citations; 24 studies met inclusion criteria, representing 12 of 36 countries. The overall pooled prevalence was 0.64 per 100,000 (prediction interval, 0.06-7.22); for cluster regions, it was 54 per 100,000 (95% CI, 34.79-84.92); for juvenile HD, it was 8.7% (prediction interval, 5.12-14.35), and 5.9% (prediction interval, 2.72-13.42) for late-onset HD. The prevalence was higher for Mexico, Peru, and Brazil. However, there were no significant differences between Central America and the Caribbean versus South America. Conclusion: The prevalence of HD appears to be similar across Latin America. However, we infer that our findings are underestimates, in part because of limited research and underdiagnosis of HD because of limited access to molecular testing and the availability of neurologists and movement disorders specialists. Future research should focus on identifying pathways to improve access to molecular testing and education and understanding differences among different ancestral groups in Latin America. © 2024 International Parkinson and Movement Disorder Society. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley-Liss es_ES
dc.subject Huntington Disease es_ES
dc.subject Enfermedad de Huntington es_ES
dc.subject Latin America es_ES
dc.subject América Latina es_ES
dc.subject Epidemiology es_ES
dc.subject Epidemiología es_ES
dc.subject Systematic Review es_ES
dc.subject Revisión Sistemática es_ES
dc.subject Meta-Analysis es_ES
dc.subject Metaanálisis es_ES
dc.subject Movement Disorders
dc.subject Trastornos del Movimiento
dc.title Epidemiology of Huntington's Disease in Latin America: A Systematic Review and Meta-Analysis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Rossi, Malco Damián. Fleni. Departamento de Neurología. Servicio de Movimientos Anormales; Argentina.
dc.description.fil Fil: Medina Escobar, Alex. Horizon Health Network; Canadá.
dc.description.fil Fil: Pringsheim, Tamara. University of Calgary; Canadá.
dc.description.fil Fil: Gautreau, Sylvia. Horizon Health Network; Canadá.
dc.description.fil Fil: Rivera Duarte, Jose D. Universidad Nacional Autónoma de Honduras; Honduras.
dc.description.fil Fil: Amorelli, Gabriel. Ottawa University; Canadá.
dc.description.fil Fil: Cornejo Olivas, Mario. Universidad Cientifica del Sur; Perú.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Movement disorders : official journal of the Movement Disorder Society
dc.relation.ispartofISSN 1531-8257
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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